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Aspirin-induced human antral injury is reduced by vodka pretreatment

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Abstract

Mild irritants have been shown to protect the rat gastric mucosa against noxious agents. This study was designed to test the protective potential of low-dose ethanol against acetylsalicylic acid (ASA) — induced gastric injury. Ten healthy volunteers who were nondrinkers and had normal baseline upper gastrointestinal endoscopy participated in a randomized double-blind crossover study. Thirty minutes after either vodka (37.5 ml) in tomato juice or tomato juice alone, each subject took 975 mg ASA and then underwent endoscopy 1 hr later. The degree of mucosal injury was scored, and blood was taken for ethanol and salicylate levels. There was a washout interval of seven days between the two treatments. Endoscopic scores were analyzed using the sign test. After a single dose of ASA, mucosal injury was confined to the fundus and antrum, while the duodenum was minimally affected. A significant reduction in antral damage was seen with ethanol pretreatment (P<0.05). The same trend was evident in the fundus but did not achieve statistical significance. Serum salicylate levels averaged 13.2± 0.8 mg/100 ml and were not different between the two treatments. Ethanol concentration ranged from 1.1 to 6.2 mmol/liter following the vodka drink and was 0 after the placebo.

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Authors and Affiliations

  1. Department of Surgery, University of Toronto and Mount Sinai Hospital, Toronto, Ontario, Canada

    M. M. Cohen MB, ChB, R. Yeung MD, S. Kilam MD & H. -R. Wang MD

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  1. M. M. Cohen MB, ChB
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  2. R. Yeung MD
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  3. S. Kilam MD
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  4. H. -R. Wang MD
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Cohen, M.M., Yeung, R., Kilam, S. et al. Aspirin-induced human antral injury is reduced by vodka pretreatment. Digest Dis Sci 33, 513–517 (1988). https://doi.org/10.1007/BF01798349

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  • DOI: https://doi.org/10.1007/BF01798349

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