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Absence of a relationship of size of primary colon carcinoma with metastasis and survival

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Abstract

This retrospective study analysed the relationship of tumor size to regional and systemic metastasis and to survival according to stage of disease. Colon cancers (391 cases) that were treated surgically at M. D. Anderson Hospital from 1955 to 1975 were reviewed. Staging of disease was based on the Astler-Coller modification of Dukes' staging classification. The mean diameters (cm±s.e.m.) of Dukes' B1, B2, C2 and D tumors were 4·47±0·34 (n=46), 6·61±0·29 (n=147), 5·39±0·23 (n=71) and 5·78±0·24 (n=120), respectively. The mean diameter of Dukes' B2 tumors was significantly greater than C2 (P<0·001) and D (P<0·05) tumors. Within stage B and C, size of the primary tumor showed no relationship to five year adjusted survival. Our findings suggest that colon carcinoma metastasis and survival are independent of tumor size. Because tumor burden does not account for distant disease, specific tumor cell phenotypes and biological processes are probably more important in determining metastatic disease.

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References

  1. Astler, V. B., andColler, F. A., 1954, The prognostic significance of direct extension of carcinoma of the colon and rectum.Annals of Surgery,139, 846–851.

    PubMed  Google Scholar 

  2. Cass, A. W., Million, R. R., andPfaff, W. W., 1976, Patterns of recurrence following surgery alone for adenocarcinoma of the colon and rectum.Cancer,37, 2861–2865.

    PubMed  Google Scholar 

  3. Coller, F. A., Kay, E. B., andMacIntyre, R. S., 1940, Regional lymphatic metastasis of carcinoma of the rectum.Surgery,8, 294–311.

    Google Scholar 

  4. Coller, F. A., Kay, E. B., andMacIntyre, R. S., 1941, Regional lymphatic metastases of carcinoma of the colon.Annals of Surgery,114, 56–67.

    Google Scholar 

  5. Cox, D. R., 1972, Regression model and life tables.Journal of Royal Statistical Society,334, 187–220.

    Google Scholar 

  6. Cutler, S. J., andEderer, F. J., 1958, Maximum utilization of the life table methods in analyzing survival.Journal of Chronic Diseases,8, 699–718.

    PubMed  Google Scholar 

  7. Dukes, C. E., 1932, The classification of cancer of the rectum.Journal of Pathology and Bacteriology,35, 323–332.

    Google Scholar 

  8. Fidler, I. J., 1978, General considerations for studies of experimental cancer metastasis.Methods in Cancer Research,15, 399–439.

    Google Scholar 

  9. Gehan, E. A., 1965, A generalized Wilcoxan test for comparing arbitrarily single censored samples.Biometrika,52, 203–223.

    PubMed  Google Scholar 

  10. Gilchrist, R. K., andDavid, V. C., 1938, Lymphatic spread of carcinoma of the rectum.Annals of Surgery,108, 621–642.

    Google Scholar 

  11. Godwin, J. D., andBrown, C. C., 1975, Some prognostic factors in survival of patients with cancer of the colon and rectum.Journal of Chronic Diseases,28, 441–454.

    PubMed  Google Scholar 

  12. Greene, H. S. N., andHarvey, E. K., 1964, The relationship between the dissemination of tumor cells and the distribution of metastasis.Cancer Research,24, 799–811.

    PubMed  Google Scholar 

  13. Grinnell, R. S., 1964, The chance of cancer and lymphatic metastasis in small colon tumors discovered on X-ray examination.Annals of Surgery,139, 132–138.

    Google Scholar 

  14. Irimura, T., Gonzalez, R., andNicolson, G. L., 1981, Effects of tunicamycin on B16 metastatic melanoma cell surface glycoproteins and blood-borne arrest and survival properties.Cancer Research,41, 3411–3418.

    PubMed  Google Scholar 

  15. Irimura, T., andNicolson, G. L., 1984, Carbohydrate chain analysis by lectin binding to electrophoretically separated glycoproteins from murine B16 melanoma sublines of various metastatic properties.Cancer Research,44, 791–798.

    PubMed  Google Scholar 

  16. Kirklin, J. W., Dockerty, M. D., andWaugh, J. W., 1949, The role of the peritoneal reflection in the prognosis of carcinoma of the rectum and sigmoid colon.Surgery, Gynecology and Obstetrics,88, 326–331.

    Google Scholar 

  17. Lockhart-Mummery, J. P., 1926, Two hundred cases of cancer of the rectum treated by perineal excision.British Journal of Surgery,27, 110–124.

    Google Scholar 

  18. Nakajama, M., Irimura, T., DiFerrante, D., DiFerrante, N., andNicolson, G. L., 1983, Heparan sulfate degradion: relation to tumor invasive and metastatic properties of mouse B16 melanoma sublines.Science,220, 611–613.

    PubMed  Google Scholar 

  19. Nicolson, G. L., 1982, Cancer metastasis: organ colonization and the cell-surface properties of malignant cells.Biochemica et Biophysica Acta,695, 113–176.

    Google Scholar 

  20. Nicolson, G. L., 1984, Tumor progression, oncogenes and the evolution of metastatic phenotypic diversity.Clinical and Experimental Metastasis,2, 85–105.

    PubMed  Google Scholar 

  21. Nicolson, G. L., Irimuri, T., Nakajima, M., andEstrada, J., 1984, Metastatic cell attachment to and invasion of vascular endothelium and its underlying basal lamina using endothelial cell monolayers.Cancer Invasion and Metastasis: Biologic and Therapeutic Aspects, edited by G. L. Nicolson and L. Milas (New York: Raven Press), pp. 145–167.

    Google Scholar 

  22. Olson, R. M., Perencevich, N. P., Malcolm, A. W., Chaffey, J. T., andWilson, R. E., 1980, Patterns of recurrence following curative resection of adenocarcinoma of the colon and rectum.Cancer,45, 2969–2974.

    PubMed  Google Scholar 

  23. Rankin, F. W., andOlson, P. F., 1983, The hopeful prognosis in cases of carcinoma of the colon.Surgery Gynecology and Obstetrics,56, 366–374.

    Google Scholar 

  24. Spratt, J. S., andSpjut, H. J., 1967, Prevalence and prognosis of individual clinical and pathologic variables associated with colorectal carcinoma.Cancer,11, 1976–1985.

    Google Scholar 

  25. Stearns, M. W., andDebbish, M. R., 1956, The influence of size on prognosis of operable cancer of the rectum and distal sigmoid.Cancer,9, 139–140.

    PubMed  Google Scholar 

  26. Sugarbaker, E. V., 1979, Cancer metastasis: a product of tumor-host interactions.Current Problems in Cancer,3, 3–59.

    Google Scholar 

  27. Turnbull, R. B., Kyle, K., Watson, F. R., andSpratt, J., 1967, Cancer of the colon: the influence of the no-touch isolation technic on survival rates.Annals of Surgery,166, 420–425.

    PubMed  Google Scholar 

  28. Welch, J. P., andDonaldson, G. A., 1979, The clinical correlation of an autopsy study of recurrent colorectal cancer.Annals of Surgery,189, 496–502.

    PubMed  Google Scholar 

  29. Wolley, R. C., Schreiber, K., Koss, L. G., Karas, M., andSherman, A., 1982, DNA distribution in human colon carcinoma and its relationship to clinical behavior.Journal of the National Cancer Institute,69, 15–22.

    PubMed  Google Scholar 

  30. Wolmark, N., Cruz, I., Redmond, C. K., Fisher, B., andFisher, E. R. (and contributing NSABP investigators), 1983, Tumor size and regional lymph node metastasis in colorectal cancer: a preliminary analysis from the NSABP clinical trials.Cancer,51, 1315–1322.

    PubMed  Google Scholar 

  31. Wolmark, N., Fisher, E. R., Wieand, S., andFisher, B. (and contributing NSABP investigators), 1984, The relationship of depth of penetration and tumor size to the number of positive nodes in Dukes' C colorectal cancer.Cancer,53, 2707–2712.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Departments of Surgery, The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, 6723 Bertner Avenue, 77030, Houston, Texas, USA

    William Miller & David Ota

  2. Departments of Patient Studies, The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, 6723 Bertner Avenue, 77030, Houston, Texas, USA

    Geoffrey Giacco & Vincent Guinee

  3. Departments of Tumor Biology, The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, 6723 Bertner Avenue, 77030, Houston, Texas, USA

    Tatsuro Irimura & Garth Nicolson

  4. Departments of Pathology, The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, 6723 Bertner Avenue, 77030, Houston, Texas, USA

    Karen Cleary

Authors
  1. William Miller
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  2. David Ota
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  3. Geoffrey Giacco
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  4. Vincent Guinee
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  5. Tatsuro Irimura
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  6. Garth Nicolson
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  7. Karen Cleary
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Miller, W., Ota, D., Giacco, G. et al. Absence of a relationship of size of primary colon carcinoma with metastasis and survival. Clin Exp Metast 3, 189–196 (1985). https://doi.org/10.1007/BF01786762

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  • DOI: https://doi.org/10.1007/BF01786762

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