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Metalloprotease inhibitors halt collagen breakdown in IL-1 induced bovine nasal cartilage cultures

  • I. Cartilage degradation and osteoarthritis
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References

  1. Stephenson ML, Goldring MB, Birkhead JR, Krane SM, Rahmsdorf HJ, Angel P. Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin-1β or phorbol ester. Biochem Biophys Res Comm 1987;144:583–90.

    PubMed  Google Scholar 

  2. Ganu VS, Hu S-I, Melton R, Winter C, Goldberg VM, Haqqi TM, Malemud CJ. Biochemical and molecular characterization of stromelysin synthesized by human osteoarthritic chondrocytes stimulated with recombinant human interleukin-1. Clin Exp Rheumatol 1994;12.

  3. Tyler JA. IGF-1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines. Biochem J 1989;260:543–8.

    Google Scholar 

  4. Caputo CB, Sygowski LA, Wolanin DJ, Patton SP, Caccese RG, Shaw A, et al. Effect of synthetic metalloprotease inhibitors on cartilage autolysis in vitro. J Pharmacol Exp Ther 1987;240:460–5.

    PubMed  Google Scholar 

  5. Nixon JS, Bottomley KK, Broadhurst MJ, Brown PA, Johnson WH, Lawton G, et al. Potent collagenase inhibitors prevent interleukin-1 induced cartilage degradation in vitro. Int J Tiss React Expt Clin Aspects 1991;13:237–41.

    Google Scholar 

  6. Goldberg RL, Kolibas LM. An improved method for determining proteoglycans synthesized by chondrocytes in culture. Conn Tiss Res 1990;24:265–75.

    Google Scholar 

  7. Woessner JF. The determination of hydroxyproline in tissue and protein samples containing small portions of this imino acid. Arch Biochem Biophys 1961;93:440–7.

    PubMed  Google Scholar 

  8. Sandy JD, Neame PJ, Boynton RE, Flannery CR. Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain. J Biol Chem 1991;266:8683–5.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Pharmaceuticals Div., Research Department, Ciba-Geigy Corp., 07901, Summit, NJ, USA

    S. Spirito, J. Doughty, E. O'Byrne, V. Ganu & R. L. Goldberg

Authors
  1. S. Spirito
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  2. J. Doughty
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  3. E. O'Byrne
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  4. V. Ganu
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  5. R. L. Goldberg
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Spirito, S., Doughty, J., O'Byrne, E. et al. Metalloprotease inhibitors halt collagen breakdown in IL-1 induced bovine nasal cartilage cultures. Inflamm Res 44 (Suppl 2), S131–S132 (1995). https://doi.org/10.1007/BF01778297

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  • DOI: https://doi.org/10.1007/BF01778297

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