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The effect of beta-adrenergic blockade in dilated cardiomyopathy — a questionnaire study in Japan

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Summary

The effect of beta-blockade in dilated cardiomyopathy was studied by a questionnaire survey. Thirty-three cases were monitored in whom metoprolol (22 patients, 35.9 ± 20.4 mg, mean ± SD), propranolol (four patients, 26.3 ± 7.5 mg), or other beta-blockers (seven patients) were administered. Four patients died, but no direct relationship was found between administration of beta-blocker and death. The NYHA functional class improved significantly. The mean heart rate decreased from 96/min to 77/min (P < 0.01). The mean cardiothoracic ratio decreased from 55.6% to 52.1% (P < 0.01). The mean ejection fraction of the left ventricle measured by echocardiogram increased from 30.4% to 36.9% (P < 0.01). Exercise tolerance in the treadmill test improved significantly. There was no change in blood pressure, nor were there arrhythmias seen on Holter electrocardiograms. In two patients, congestive heart failure deteriorated after administration of beta-blockers. It is concluded that beta-adrenergic blockade has a beneficial effect in most of the patients with dilated cardiomyopathy.

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References

  1. Waagstein F, Hjalmarson A, Varnauskas E, et al. (1975) Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy. Br Heart J 37:1022

    PubMed  Google Scholar 

  2. Alderman J, Grossman WG (1985) Are beta-adrenergicblocking drugs useful in the treatment of dilated cardiomyopathy? Circulation 71:854

    PubMed  Google Scholar 

  3. Ikram H, Fitzpatrick MA (1983) Beta-blockade for dilated cardiomyopathy: The evidence against therapeutic benefit. Eur Heart J 4 (Suppl A):179

    PubMed  Google Scholar 

  4. Swedberg K, Waagstein F, Hjalmarson A, et al. (1979) Prolongation of survival in congestive cardiomyopathy by beta-receptor blockade. Lancet I:1374

    Google Scholar 

  5. Ikram H, Fitzpatrick D (1981) Double-blind trial of chronic oral beta-blockade in congestive cardiomyopathy. Lancet II:490

    Google Scholar 

  6. Currie PJ, Kelly MJ, McKenzie A, et al. (1984) Oral beta-adrenergic blockade with metoprolol in chronic severe dilated cardiomyopathy. J Am Coll Cardiol 3:203

    PubMed  Google Scholar 

  7. Anderson JL, Lutz JR, Gilbert EM, et al. (1985) A randomized trial of low-dose beta-blockade therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 55:471

    PubMed  Google Scholar 

  8. Engelmeir RS, O'Connell JB, Walsh R, et al. (1985) Improvement in symptoms and exercise tolerance by metoprolol in patients with dilated cardiomyopathy: A double-blind, randomized, placebo-controlled trial. Circulation 72:536

    PubMed  Google Scholar 

  9. Waagstein F, Caidahl K, Wallentin I, Bergh CH, Hjalmarson A (1989) Long-term β-blockade in dilated cardiomyopathy. Circulation 80:551

    PubMed  Google Scholar 

  10. Gilbert EM, Anderson JL, Deitchman D, Yanowitz FG, O'Connell JB, Renlund DG, Bartholomew M, Mealey PC, Larrabee P, Bristow MR (1990) Long-term β-blocker vasodilator therapy improves cardiac function in idiopathic dilated cardiomyopathy: A double-blind, randomized study of bucindolol versus placebo. Am J Med 88:223

    PubMed  Google Scholar 

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Authors and Affiliations

  1. The Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Akira Matsumori, Makoto Tominaga & Chuichi Kawai

  2. Keio University, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Shunnosuke Handa

  3. University of Occupational and Environmental Health, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Yasunori Fukuchi

  4. Osaka University, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Akira Kitabatake

  5. Kagawa Medical School, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Hirohide Matsuo

  6. Saga Medical School, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Shuzo Matsuo

  7. Fukui Cardiovascular Center, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Junichiro Mihune

  8. Mie University, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Takeshi Nakano

  9. St. Marianna University, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Sachihiko Nobuoka

  10. Jikei University, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Tetsuo Okamura

  11. Asahikawa Medical College, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Sokichi Onodera

  12. Kawasaki Medical School, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Toshitami Sawayama

  13. Tokyo Women's Medical College, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Atsuyoshi Takao

  14. Kurume University, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Hironori Toshima

  15. Aichi Medical University, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Tsutomu Watanabe

  16. Hokkaido University, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Hisakazu Yasuda

  17. Yamagata University, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Shoji Yasui

  18. Yokohama City University, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Hiroshi Yoshimura

Authors
  1. Akira Matsumori
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  2. Makoto Tominaga
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  3. Shunnosuke Handa
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  4. Yasunori Fukuchi
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  5. Akira Kitabatake
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  6. Hirohide Matsuo
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  7. Shuzo Matsuo
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  8. Junichiro Mihune
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  9. Takeshi Nakano
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  10. Sachihiko Nobuoka
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  11. Tetsuo Okamura
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  12. Sokichi Onodera
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  13. Toshitami Sawayama
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  14. Atsuyoshi Takao
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  15. Hironori Toshima
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  16. Tsutomu Watanabe
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  17. Hisakazu Yasuda
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  18. Shoji Yasui
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  19. Hiroshi Yoshimura
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  20. Chuichi Kawai
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Additional information

This work was supported in part by a research grant from the Ministry of Health and Welfare and by a grant-in-aid for scientific research on priority areas and for general scientific research from the Ministry of Education, Science, and Culture, Japan, and Kanazawa Research Fund.

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Matsumori, A., Tominaga, M., Handa, S. et al. The effect of beta-adrenergic blockade in dilated cardiomyopathy — a questionnaire study in Japan. Heart Vessels 6 (Suppl 1), 6–10 (1991). https://doi.org/10.1007/BF01752530

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  • DOI: https://doi.org/10.1007/BF01752530

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