Abstract
A series of 199 male regular sexual partners of women attending an STD clinic for the examination and treatment of HPV-associated diseases was examined by peniscopy, surgical biopsy and nucleic acid hybridization for the presence of clinical, histological and molecular markers pathognomic of HPV infection. There was a 100% correlation between condylomata acuminata and detection of HPV type 6 or 11 DNA. Papillary lesions displayed neither histological signs of HPV infection, nor did they harbor HPV DNA (viral types 6, 11, 16, 18, 33) while 44.9% (22/49) of acetowhite epithelia showed HPV-suggestive histological changes. Of the 19 analysed for HPV DNA, 15.8% (3/19) harbored HPV 6/11 and 16 DNA. Regular male and female sexual partners did not always harbor the same HPV types, showing that latent or occult infection and the sexual habits of each individual play an important role in the clinical manifestations of HPV infection observed in sexual couples. The present data show that: i) the likelihood of developing a clinical HPV lesion was affected, to a large extent, by the previous sexual history and habits in the partners of women with flat condylomata, while partners of women with condylomata acuminata or CINs displayed a higher correlation with the current state of infection in their regular partner; ii) despite the assessed infective state of their consorts, men with a low lifetime number of sexual partners seldom displayed HPV-associated acetowhitening. Prevalence of such lesions, however, increased significantly with an increase in the total number of sexual partners; iii) clinical assessment and evaluation of HPV-risk for inconspicuous penile lesions in the male partner should be carried out not only on the basis of clinical and peniscopic appearance, but also considering the current state of infection in the regular partner and the sexual history and habits of each individual.
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References
Barrasso R. HPV-related genital lesions in men. In: Munoz N, Bosch FX, Shah KV, Meheus A, eds, The epidemiology of cervical cancer and human papillomavirus. Lyon: IARC Scientific Publications, 1992: 85–92.
Campion MJ, McCance DJ, Mitchell HS, Jenkin DP, Singer A. Subclinical penil papillomavirus infection and dysplasia in consorts of women with cervical dysplasia. Genitour Med 1988; 64: 90–99.
Costa S, Syrjanen S, Vendra C, Chang F, Guida G, Tervahauta A, Hippelainen M, Hippelainen K. Detection of human papillomavirus infections in the male sexual partners of women attending an STD clinic in Bologna. Int J STD AIDS 1992; 3: 338–346.
Munoz N, Bosch FX. HPV and cervical neoplasia: Review of case-control and cohort studies. In: Munoz N, Bosch FX, Shah KV, Meheus A, eds, The epidemiology of cervical cancer and human papillomavirus. Lyon: IARC Scientific Publications, 1992: 251–261.
Nuovo GJ, Hochman HA, Eliezri YD, Lastarria D, Comite SL, Silvers DN. Detection of human papillomavirus DNA in penile lesions histologically negative for condylomata. Am J Surg Pathol 1990; 14: 829–836.
Van den Brule AJ, Walboomers JM, Du Maine M, Meijer CJ. Difference in prevalence of human papilloma virus genotypes in cytomorphologically normal cervical smears is associated with a history of cervical intraepithelial neoplasia. Int J Cancer 1991; 48: 404–408.
Zur Hausen H. Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 1991; 184: 9–13.
De Villiers EM. Heterogeneity of the human papillomavirus group. J Virol 1989; 63: 4898–4903.
Fuchs PG, Girardi F, Pfister H. Human papillomavirus DNA in normal, metaplastic preneoplastic and neoplastic epithelia of the cervix uteri. Int J Cancer 1988; 41: 41–45.
McNicol PJ, Dodd JG. High prevalence of human papillomavirus in prostate tissues. J Urol 1991; 145: 850–853.
Meanwell CA, Blackledge G, Cox MF, Maitland NJ. HPV 16 DNA in normal and malignant cervical epithelium: Implications for the aetiology and behaviour of cervical neoplasia. Lancet 1987; i: 703–707.
Ostrow R, Zachow K, Nimura M, Okagaki T, Muller S, Benser M, Faras A. Detection of papillomavirus in human semen. Science 1986; 231: 731–733.
Rotola A, Monini P, Di Luca D, Savioli A, Simone R, Secchiero P, Reggiani A, Cassai E. Presence and physical state of HPV DNA in prostate and urinary-tract tissues. Int J Cancer 1992; 52: 359–365.
Katelaris PM, Cossart YE, Rose BR, Thompson CH, Sorich E, Nightingale B, Dallas PB, Morris BJ. Human papillomavirus: The untreated male reservoir. J Urol 1988; 140: 300–305.
Oriel JD. Natural history of genital warts. Br J Vener Dis 1971; 47: 1–13.
Daling JR, Sherman KJ, Weiss NS. Risk factors for condyloma acuminatum in women. Sex Transm Dis 1986; 13: 16–18.
Ley C, Bauer HM, Reingold A, Chambers JC, Tashiro CJ, Manos MM. Determinants of genital papillomavirus infection in young women. J Natl Cancer Inst 1991; 83: 997–1003.
Azocar J, Abad SM, Acosta H, Hernandez R, Gallegos M, Pifano E, Blanch R, Kramar A. Prevalence of cervical dysplasia and HPV infection according to sexual behavior. Int J Cancer 1990; 45: 622–625.
Moscicki AB, Palefsky J, Gonzales J, Schoolnik GK. Human papillomavirus infection in sexually active adolescent females: Prevalence and risk factors. Pediatr Res 1990; 28: 507–513.
Franco EL. The sexually transmitted disease model for cervical cancer: Incoherent epidemiologic findings and the role of misclassification of human papillomavirus infection. Epidemiology 1991; 2: 98–106.
Hippelhinen M, Yliskoski M, Saarikosky S, Syjrianen S, Syrjanen K. Colposcopic analysis of genital human papillomavirus (HPV) lesions of the male sexual partners. Genitourin Med 1991; 67: 291–296.
Levine RV, Crum CP, Herman E, Silvers D, Ferenczy A, Richart RM. Cervical papillomavirus infection and intraepithelial neoplasia: A study of male sexual partners. Obst Gynecol 1984; 64: 16.
Omar R, Choudhury M, Fischer J, Ezpeleta CA. ‘PAP’ test for men? Male urethral smears as screening tool for detecting subclinical human papillomavirus infection. Urology 1991; 37: 110–115.
Sand PK, Bowen LW, Blischke SO, Ostergard DR. Evaluation of male consorts of women with genital papillomavirus infection. Obst Gynecol 1986; 68: 679–681.
Wilkstrom A, Lidbrink P, Johansson B, von Grog G. Penile human papillomavirus carriage among men attending Swedish STD clinics. Int J STD AIDS 1991; 2: 105–109.
Schneider A, Kirchmayr R, De Villiers EM, Gissmann L. Subclinical human papillomavirus infections in male sexual partners of female carriers. J Urol 1988; 140: 1431–1434.
Wickenden C, Hanna N, Taylor-Robinson D, Harris JRW, Bellami C, Carroll P, Malcolm ADB, Coleman DV. Sexual transmission of human papillomaviruses in heterosexual and male homosexual couples, studied by DNA hybridization. Genitourin Med 1988; 64: 34–38.
Koss iLG. Natural history of epidermoid carcinoma of the uterine cervix. Papillomaviruses in human pathology recent progress in epidermoid precancers, Serono Symposia Publications vol 78. New York, NY: Raven Press, 1990.
Reid R, Stanhope R, Herschmann BR, Crum CD. Genital warts and genital cancer. IV. A colposcopic index for differentiating subclinical papillomaviral infection from cervical intraepithelial neoplasia. Am J Obstet Gynecol 1984; 149: 815–823.
Kafatos FC, Jones WC, Esfradiatis A. Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure. Nucl Acids Res 1979; 7: 1541–1552.
Marchetti G, Patracchini P, Aiello V, Calzolari E, Del Senno L, Bernardi F, Gambari R, Anglani F, Conconi F. Characterization and chromosomal localization of two clones from an X chromosome. Cytogenet Cell Genet 1985; 40: 691.
Barrasso R, Jablonska S. Clinical, colposcopic and histologic spectrum of male human papillomavirus-associated genital lesions. Clin Pract Gynecol 1989; 2: 73–101.
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Rotola, A., Costa, S., Monini, P. et al. Impact of sexual habits on the clinical evaluation of male HPV infection. Eur J Epidemiol 10, 373–380 (1994). https://doi.org/10.1007/BF01719659
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DOI: https://doi.org/10.1007/BF01719659