Abstract
The case of an 11-year-old boy who suffered second and third degree burns to 78% of his body is reported. The large doses of morphine used as analgesia resulted in severe side effects: ventilatory dependence, impairment of gastrointestinal function and psychological disturbance. Intravenous lignocaine was added without benefit. The addition of low-dose intravenous clonidine, however, precipitated a dramatic reduction in morphine consumption with an attendant improvement in ventilatory, gastrointestinal and psychological functions.
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Lyons, B., Casey, W., Doherty, P. et al. Pain relief with low-dose intravenous clonidine in a child with severe burns. Intensive Care Med 22, 249–251 (1996). https://doi.org/10.1007/BF01712245
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DOI: https://doi.org/10.1007/BF01712245