Abstract
A case of oral ingestion of large doses of both the amphetamine-derivative 3,4-methylene dioxyethamphetamine (MDEA) and heroin is reported. Despite high serum levels of both drugs, the patient did not present with the classic signs and symptoms normally seen during intoxication with these drugs. The patient recovered after symptomatic treatment. The possibility that opposite pharmacological properties of the two drugs prevented the patients death is discussed.
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Dowling GP, McDonough ET III, Bost RO (1987) “Eve” and “Ecstasy.” A report of five deaths associated with the use of MDEA and MDMA. JAMA 257: 1615–1617
Rattray M (1991) Ecstasy: towards an understanding of the biochemical basis of the actions of MDMA. Essays Biochem 26: 77–87
Henry JA, Jeffreys KJ, Dawling S (1992) Toxicity and deaths from 3,4-methylene dioxymethamphetamine (“Ecstasy”). Lancet 340: 384–387
Tehan B, Hardern R, Bodenham A (1993) Hyperthermia associated with 3,4-methylene dioxyethamphetamine (“Eve”). Anaesthesia 48: 507–510
Chadwick IS, Linsley A, Freemont AJ, Doran B (1991) Ecstasy, 3,4-methylene dioxymethamphetamine (MDMA), a fatality associated with coagulopathy and hyperthermia. J R Soc Med 84: 371
Ricaurte G, Bryan G, Strauss L, Seiden L, Schuster C (1985) Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals. Science 229: 986–988
Johnson MP, Hoffman AJ, Nichols DE (1986) Effects of the enantiomers of MDA, MDMA and related analogues on [3H] serotonin and [3H] dopamin release from superfused rat brain slices. Eur J Pharmacol 132: 269–276
Rudnick G, Wall SC (1992) The molecular mechanism of “ecstasy” [3,4-methylene dioxymethamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Proc Natl Acad Sci USA 89: 1817–1821
Schmidt CJ, Taylor VL, Abbate GM, Nieuduzak TR (1991) 5HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylene dioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa. J Pharmacol Exp Ther 256: 230–235
Ricaurte GA, Finnegan KF, Nichols DE, DeLamey LE, Irwin I, Langston JW (1987) 3,4-methylene dioxyethylamphetamine (MDE), a novel analogue of MDMA, produces long-lasting depletion of serotomin in the rat brain. Eur J Pharmacol 137: 265–268
Schmidt CJ (1987) Acute administration of methylene dioxymethamphetamine: comparison with the neurochemical effects of its N-desmethyl and N-ethyl analogues. Eur J Pharmacol 136: 81–88
Boja JW, Schechter M (1987) Behavioral effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE; “Eve”). Pharmacol Biochem Behav 28: 153–156
Price LP, Ricarte GA, Krystal JH, Heninger GR (1989) Neuroendocrine and mood response to intravenousl-tryptophan in 3,4-methylenedioxymethamphetamine (MDMA) users. Arch Gen Psychiatry 46: 20–28
Gouzoulis E, van Bardeleber U, Rupp A, Kovar KA, Hermle L (1993) Neuroendocrine and cardiovascular effects of MDE in healthy volunteers. Neuropsychopharmacology 8: 187–193
Moffat AC (ed) (1986) Clarke's isolation and identification of drugs. Pharmaceutical Press, London
Ellenhorn MJ, Barceloux DG (eds) (1988) Medical Toxicology. Diagnosis and treatment of human poisoning. Elsevier, New York
Hertting G, Wurster S, Allgaier C (1990) Regulatory proteins in presynaptic function. Ann NY Acad Sci 604: 289–304
Sawynok J (1989) The role of ascending and descending noradrenergic and serotonergic pathways in opioid and non-opioid antinociception as revealed by lesion studies. Can J Physiol Pharmacol 167: 975–988
Richelson E, Pfenning M (1984) Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: most antidepressants selectively block norepinephrine uptake. Eur J Pharmacol 104: 277–282
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Jorens, P.G., Heytens, L., Demey, H.E. et al. Acute poisoning with amphetamines (MDEA) and heroin: Antagonistic effects between the two drugs. Intensive Care Med 22, 456–459 (1996). https://doi.org/10.1007/BF01712166
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DOI: https://doi.org/10.1007/BF01712166