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Influence of a proton pump inhibitor-based therapy onHelicobacter pylori strain selection

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Abstract

The influence of the proton pump inhibitor lansoprazole on strain diversity inHelicobacter pylori infected patients was investigated. Multiple isolates ofHelicobacter pylori obtained pre- and post-therapy from gastric antral and body biopsies in 22 patients were compared using the random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) for analysis. Post-therapy strains exhibiting novel RAPD-profiles were found in 5 of 22 patients (4 of 11 patients treated with lansoprazole alone and 1 of 11 patients treated with lansoprazole plus amoxicillin). Proton pump inhibition may affect the microecology of the stomach by influencing the colonisation patterns of specific strains.

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Authors and Affiliations

  1. School of Microbiology and Immunology, The University of New South Wales, 2052, Sydney, Australia

    S. L. Hazell, H. M. Mitchell & G. Hanna

  2. Inner West Endoscopy Centre, 2204, Sydney, Australia

    G. Daskalopoulos

Authors
  1. S. L. Hazell
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  2. H. M. Mitchell
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  3. G. Hanna
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  4. G. Daskalopoulos
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Hazell, S.L., Mitchell, H.M., Hanna, G. et al. Influence of a proton pump inhibitor-based therapy onHelicobacter pylori strain selection. Eur. J. Clin. Microbiol. Infect. Dis. 16, 530–532 (1997). https://doi.org/10.1007/BF01708237

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  • DOI: https://doi.org/10.1007/BF01708237

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