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Plasma ionized calcium in brain-dead patients

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Abstract

Background

The mechanism of brain death-induced myocardial dysfunction remains debatable. Hypocalcemia is known to induce reversible myocardial dysfunction. However, the incidence of hypocalcemia and its effect on myocardial function during brain death is unknown.

Methods

In 54 consecutive braindead patients, we measured plasma total and ionized calcium concentrations, QT and corrected QT intervals, and left ventricular ejection fraction area (LVEFa), using transesophageal echocardiography.

Results

49 (91%) of brain-dead patients had a decrease in total plasma total calcium concentration but only 19 (35%) had a decrease in plasma ionized calcium. Corrected total plasma calcium failed to predict ionized calcium concentration and QT intervals were not significantly different in normo and hypocalcemic patients. The LVEFa was not significantly different between normo and hypocalcemic patients (53±13 versus 50±20%), and no correlation was found between LVEFa and ionized calcium (R=0.02, NS). Hypocalcemic patients required greater doses of dopamine (8.2±5.2 versus 5.0±3.4 μg·kg−·min−1,p<0.02) to maintain arterial pressure. Hypocalcemia was associated with a higher volume loading and a lower plasma protide concentration which reflected hemodilution.

Conclusion

A decrease in plasma ionized calcium is not frequent, rarely severe, and probably not the main mechanism of myocardial dysfunction in brain-dead patients. Hypocalcemic patients required higher doses of dopamine, suggesting a decrease in systemic resistance. Only direct measurement of ionized calcium can assess plasma calcium ion status in brain-dead patients.

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Authors and Affiliations

  1. Département d'Anesthésie-Réanimation, Groupe Hospitalier Pitié-Salpêtrière, Université Paris VI, 47 Boulveard de l'Hôpital, F-75651, Paris Cedex, France

    J. P. Fulgenico, B. Riou, R. Guesde, M. Saada & P. Viars

  2. Laboratoire de Biologie des Urgences, Groupe Hospitalier Pitié-Salpêtrière, Université Paris VI, 47 Boulevard de l'Hôpital, F-75651, Paris Cedex, France

    C. Devilliers

Authors
  1. J. P. Fulgenico
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  2. B. Riou
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  3. C. Devilliers
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  4. R. Guesde
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  5. M. Saada
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  6. P. Viars
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Fulgenico, J.P., Riou, B., Devilliers, C. et al. Plasma ionized calcium in brain-dead patients. Intensive Care Med 21, 832–837 (1995). https://doi.org/10.1007/BF01700967

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  • DOI: https://doi.org/10.1007/BF01700967

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