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Prevalence ofHelicobacter pylori resistance to several antimicrobial agents in a region of Germany

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Abstract

To evaluate the prevalence of resistance amongHelicobacter pylori in Germany, the minimum inhibitory concentrations of amoxicillin, tetracycline, clarithromycin, and metronidazole were determined by means of the E test, for 271Helicobacter pylori isolates cultured from biopsies taken during routine endoscopies in 1996 and 1997. The prevalence of metronidazole resistance was 32.1%, with resistance found more frequently in women (38.5%) than in men (24.4%). Clarithromycin resistance was rare (3.3%). Eight of nine strains resistant to clarithromycin were also resistant to metronidazole. Resistance to either metronidazole or clarithromycin was significantly (P=0.022) higher in patients with duodenal ulcer. No strain was found to be resistant to amoxicillin or tetracyline.

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Authors and Affiliations

  1. Institute of Medical Microbiology, Otto-von-Guericke University Magdeburg, Leipziger Straße 44, D-39120, Magdeburg, Germany

    K. Wolle, W. A. Müller & W. König

  2. Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University Magdeburg, Leipziger Straße 44, D-39120, Magdeburg, Germany

    M. Nilius, A. Leodolter & P. Malfertheiner

Authors
  1. K. Wolle
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  2. M. Nilius
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  3. A. Leodolter
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  4. W. A. Müller
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  5. P. Malfertheiner
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  6. W. König
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Wolle, K., Nilius, M., Leodolter, A. et al. Prevalence ofHelicobacter pylori resistance to several antimicrobial agents in a region of Germany. Eur. J. Clin. Microbiol. Infect. Dis. 17, 519–521 (1998). https://doi.org/10.1007/BF01691138

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