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Rectal manifestations of pellagra

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Abstract

Twenty (44%) of 45 patients with cutaneous pellagra had diarrhoea. Inflammation was seen on sigmoidoscopy in 42 and was severe in 5 (11%), moderate in 4 (9%) and mild in 33 (73%). Six patients (13%) had perianal excoriation. Rectal biopsies taken in all cases showed extensive ulceration in 1 case, moderate to severe inflammation in 16 (36%) and mild inflammation in 18 (40%). Minimal oedema of the lamina propria was seen in 11 (24%) patients. At 5 to 7 days after starting vitamin treatment in nine cases histological changes had returned to normal in 4, improved in 3 and had not changed in 2. Diarrhoea stopped within a week in all cases.

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Authors and Affiliations

  1. Gastroenterology Unit, Baragwanath Hospital, Bertsham, South Africa

    I. Segal, L. Ou. Tim, A. Demetriou & M. Lerios

  2. University of the Witwatersrand, Johannesburg, South Africa

    I. Segal, L. Ou. Tim, A. Demetriou & M. Lerios

  3. Department of Histopathology, School of Pathology, South African Institute for Medical Research, University of the Witwatersrand, Johannesburg, South Africa

    A. Paterson & M. Hale

Authors
  1. I. Segal
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  2. L. Ou. Tim
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  3. A. Demetriou
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  4. A. Paterson
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  5. M. Hale
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  6. M. Lerios
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Segal, I., Tim, L.O., Demetriou, A. et al. Rectal manifestations of pellagra. Int J Colorect Dis 1, 238–243 (1986). https://doi.org/10.1007/BF01648345

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  • DOI: https://doi.org/10.1007/BF01648345

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