Summary
A case of adenocarcinoma of the cervical oesophagus was examined by employing a battery of histochemical techniques and was demonstrated to arise from ectopic gastric mucosa. The patient was a 66-year-old Japanese male. Endoscopy revealed an ulcerated tumour on the right anterior wall of the cervical oesophagus, approximately 16 cm from the incisor teeth. Pathological examination of surgically removed specimens showed well-differentiated tubular adenocarcinoma. Ectopic gastric mucosa was found in the oesophageal mucosa adjoining the carcinoma. Histochemical stains for characterizing mucosubstances and immunostains for various antigens were used. In addition to this carcinoma, ectopic gastric mucosa in the oesophagus and normal oesophageal, cardiac, tracheal and bronchial mucosa were also examined. The results showed that the carcinoma contained mucins, which showed reactivities characteristic of the gastric surface mucous cell (galactose oxidase-cold thionin Schiff reactive) and gland mucous cell (paradoxical concanavalin A staining reactive). Ectopic gastric mucosa consistently contained these mucins, but other tissue sites lacked them.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Christensen WN, Sternberg SS (1987) Adenocarcinoma of the upper esophagus arising in ectopic gastric mucosa; two case reports and review of the literature. Am J Surg Pathol 11:397–402
Culling CFA, Reid PE, Clay MG, Dunn WL (1974) The histochemical demonstration ofO-acetylated sialic acid in gastrointestinal mucins: their association with the potassium hydroxide-periodic acid-Schiff effect. J Histochem Cytochem 22:826–831
Ellis FH, Jackson RC, Krueger JT, Moersch HJ, Clagett OT, Gage RP (1959) Carcinoma of the esophagus and cardia; result of treatment, 1946 to 1956. N Engl J Med 260:351–358
Fujita H, Kakegawa T, Kumagaya Y (1979) Adenoid cystic carcinoma arising from esophagus (in Japanese). Gan No Rinsho 25:235–241
Goldman H, Antonioli DA (1982) Mucosal biopsy of the esophagus, stomach, and proximal duodenum. Hum Pathol 13:423–448
Jabbari M, Goresky CA, Lough J, Yaffe C, Daly D, Cote C (1985) The inlet patch: heterotopic gastric mucosa in the upper esophagus. Gastroenterology 89:352–356
Katsuyama T, Ono K, Nakayama J, Kanai M (1985) Recent advances in mucosubstance histochemistry. In: Kawai K (ed) Gastric mucus secreting cells. Excerpta Medica, Amsterdam, pp3–18
Morson BC, Belcher JR (1953) Adenocarcinoma of the oesophagus and ectopic gastric mucosa. Br J Cancer 6:127–132
Nakayama K, Yanagisawa F, Suzuki K, Nakano K, Hoshino K, Onodera M, Yokoyama T, Mochizuki N (1964) Primary esophageal adenocarcinoma (in Japanese). Gan No Rinsho 10:8–16
Ota H, Katsuyama T, Ishii K, Nakayama J, Shiozawa T, Tsukahara Y (1991) A dual staining method for identifying mucins of different gastric epithelial mucous cells. Histochem J 23:22–28
Puestow CB, Gillesby WJ, Guznon VL (1955) Carcinoma of the esophagus. Arch Surg 70:662–666
Raphael HA, Ellis FH, Dockerty MB (1966) Primary adenocarcinoma of the esophagus; 18-year review and review of literature. Ann Surg 164:785–796
Sakamoto G, Nakamura K, Saito K, Sato M, Sugahara T (1970) Primary adenocarcinoma arising from heterotopic gastric glands of the esophagus (in Japanese). Gan No Rinsho 16:1105–1110
Schridde H (1951) Heterotopic gastric mucosa in esophagus with ulceration and stricture formation. J Thorac Surg 21:306–312
Setoguchi M, Harada T, Nagao N, Hirata K, Ayabe K, Kajiwara Y, Matsuo T (1990) A case of esophageal carcinoma arising in esophageal gland that appeared as submucosal tumor (in Japanese) [abstract] (in Japanese). In: Abstracts of the 39th Annual Meeting of Gastroenterological Endoscopy. Japanese Society of Gastroenterological Endoscopy, Tokyo, p 344
Smithers DW (1956) Adenocarcinoma of the esophagus. Thorax 11:257–261
Spicer SS, Horn RG, Leppi TJ (1967) Histochemistry of connective tissue mucopolysaccharides. In: Wagner BW, Smith DE (eds) The connective tissue. Williams and Wilkins, Baltimore, pp 251–303
Suganuma T, Katsuyama T, Tsukahara M, Tatematsu M, Sakakura Y, Murata F (1981) Comparative histochemical study of alimentary tract with special reference to the mucous neck cells of the stomach. Am J Anat 161:219–238
Tatematsu M, Furihata C, Katsuyama T, Miki K, Honda H, Konishi Y, Ito N (1986) Gastric and intestinal phenotypic expressions of human signet ring cell carcinomas revealed by their biochemistry, mucin histochemistry and ultrastructure. Cancer Res 46:4866–4872
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ishii, K., Ota, H., Nakayama, J. et al. Adenocarcinoma of the cervical oesophagus arising from ectopic gastric mucosa. Vichows Archiv A Pathol Anat 419, 159–164 (1991). https://doi.org/10.1007/BF01600231
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01600231