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Increased incidence of neutralizing autoantibodies against interleukin-1α (IL-1α) in nondestructive chronic polyarthritis

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Abstract

Cytokines such as IL-1 and tumor necrosis factor a (TNFa) play a critical role in chronic joint inflammation and destruction. To study their regulation, we looked for circulating antiproinflammatory cytokine autoantibodies in 318 patients with chronic arthritis by immunoprecipitation with protein G. Anti-IL-1α but not anti-IL-1β or anti-TNFα IgG antibodies were detected in 9% of blood donors and 18.9% of chronic arthritis patients. These antibodies were found more commonly and at a higher level in patients with nondestructive arthritis. Negative correlations were observed between the antibody levels and indices of disease activity and joint destruction. There was a negative association between the presence of anti-IL-1α antibodies and that of HLA-DR4. These circulating anti-IL-1α antibodies were not complexed with IL-1α and could block specifically the biological activity of IL-1α and its binding to membrane IL-1 receptors. These results indicate that these antibodies are beneficial, suggesting their contribution in the clinical presentation.

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Authors and Affiliations

  1. Departments of Immunology and Rheumatology, Hôpital Edouard Herriot, 69437, Lyon Cedex 03, France

    Patricia Jouvenne & Pierre Miossec

  2. Schering-Plough Laboratory for Immunological Research, Dardilly, France

    François Fossiez, Pierre Garrone, Odile Djossou & Jacques Banchereau

Authors
  1. Patricia Jouvenne
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  2. François Fossiez
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  3. Pierre Garrone
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  4. Odile Djossou
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  5. Jacques Banchereau
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  6. Pierre Miossec
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Jouvenne, P., Fossiez, F., Garrone, P. et al. Increased incidence of neutralizing autoantibodies against interleukin-1α (IL-1α) in nondestructive chronic polyarthritis. J Clin Immunol 16, 283–290 (1996). https://doi.org/10.1007/BF01541394

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  • DOI: https://doi.org/10.1007/BF01541394

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