Abstract
In this study we describe in detail the characteristics of sphincter of Oddi motor function in a large group of healthy subjects. Studies were obtained in 50 healthy volunteers. The findings showed a sphincter of Oddi segment that had a basal pressure of 14.8±6.3 mm Hg (X±sd). Phasic contractions were superimposed on the basal pressure. They had an amplitude of 119.7±32 mm Hg, a duration of 4.7±1 sec, and a frequency of 5.7±1.2 contractions/min. In 40 subjects the propagation sequence of phasic contractions could be evaluated and were simultaneous in 53%, antegrade in 35%, and retrograde in 11% of the waves. In 20 subjects, pressure measurements done at the common bile duct sphincter were similar to those obtained at the pancreatic duct sphincter. In 10 subjects, pressure values obtained at the common bile duct sphincter within a week were similar. Our study should help to establish standards for normal manometric values of the sphincter of Oddi and emphasizes the importance of having a healthy volunteer group from which to obtain the normal values of sphincter of Oddi motor function.
Similar content being viewed by others
References
Geenen JE, Hogan WJ, Dodds WJ, Stewart ET, Arndorfer RC: Intraluminal pressure recording from the human sphincter of Oddi. Gastroenterology 78:317–324, 1980
Bar-Meier S, Geenen JE, Hogan WJ, Dodds WJ, Stewart ET, Arndorfer RC: Biliary and pancreatic duct pressures measured by ERCP manometry in patients with suspected papillary stenosis. Dig Dis Sci 24:209–213, 1979
Csendes A, Kruse A, Funch-Jensen P, Oster MJ, Ornsholt J, Amdrup E: Pressure measurements in the biliary and pancreatic duct systems in controls and in patients with gallstones, previous cholecystectomy, or common bile duct stones. Gastroenterology 77:1203–1210, 1979
Guelrud M, Mendoza S, Vicent S, Gomez M, Villalta B: Pressures in the sphincter of Oddi in patients with gallstones, common duct stones, and recurrent pancreatitis. J Clin Gastroenterol 5:37–41, 1983
Guelrud M, Siegel JH: Hypertensive pancreatic duct sphincter as a cause of pancreatitis. Successful treatment with hydrostatic balloon dilatation. Dig Dis Sci 29:225–231, 1984
De Masi E, Corazziari E, Habib FI, Fontana B, Gatti V, Fegiz GF, Torsoli A: Manometric study of the sphincter of Oddi in patients with and without common bile duct stones. Gut 25:275–278, 1984
Gregg JA, Carr-Locke DL: Endoscopic pancreatic and biliary manometry in pancreatic, biliary and papillary disease, and after endoscopic sphincterotomy and surgical exploration. Gut 25:1247–1254, 1984
Meshkinpour H, Mollot M, Eckerling GB, Bookman L: Bile duct dyskinesia. Clinical and manometric study. Gastroenterology 87:759–762, 1984
Toouli J, Geenen JE, Hogan WJ, Dodds WJ, Arndorfer RC: Sphincter of Oddi motor activity: A comparison between patients with common bile duct stones and controls. Gastroenterology 82:111–117, 1982
Toouli J, Roberts-Thomson IC, Dent J, Lee J: Sphincter of Oddi motility disorders in patients with idiopathic recurrent pancreatitis. Br J Surg 72:859–863, 1985
Nebel OT: Manometric evaluation of the papilla of Vater. Gastrointest Endosc 21:126–128, 1975
Arndorfer RC, Steff JJ, Dodds WJ, Linehan JH, Hogan WJ: Improved infusion system for intraluminal esophageal manometry. Gastroenterology 73:23–27, 1977
Vondrasek P, Eberhardt G, Classen M: Endoscopic semiconductor manometry. Int J Med 3:188–192, 1974
Carr-Locke DL, Gregg JA: Endoscopic manometry of pancreatic and biliary sphincter zones in man: Basal results in healthy volunteers. Dig Dis Sci 26:7–15, 1981
Guelrud M, Bettarello A, Cecconello I, Pinotti W, Mantelmacher H, Velasquez H: Sphincter of Oddi pressure in chagasic patients with megaesophagus. Gastroenterology 85:584–588, 1983
De Masi E, Corazziari E, Gatti V, Dominijanni D, Habib FI, Battistini A, Fegiz G, Torsoli A: Perendoscopic manometry of the sphincter of Oddi. Surg Gastroenterol 1:335–339, 1982
Welch RW, Luckmann KF, Ricks PM, Drake ST, Bannayan G, Owensky L: Lower esophageal sphincter pressure in histologic esophagitis. Dig Dis Sci 25:420–426, 1980
Toouli J, Roberts-Thomson IC, Dent J, Lee J: Manometric disorders in patients with suspected sphincter of Oddi dysfunction. Gastroenterology 88:1243–1250, 1985
Toouli J, Dodds WJ, Honda R, Sarna S, Hogan WJ, Komarowski R, Linehan JH, Arndorfer RC: Motor function of the opossum sphincter of Oddi. J Clin Invest 71:208–220, 1983
Burget GE, Brocklehurst RJ: The bile-expelling mechanism in the guinea pig. Am J Physiol 83:578–588, 1928
Dubois FS, Hunt EA: Peristalsis of the common bile duct in the opossum. Anat Rec 53:387–397, 1932
Behar J, Biancani P: Role of cat sphincter of Oddi motor activity on trans-sphincteric flow (TSF). Gastroenterology 88:1320, 1985
Scott RB, Strasberg SM, El-Sharkawy TY, Diamant NE: Fasting canine biliary secretion and the sphincter of Oddi. Gastroenterology 87:793–804, 1984
Torsoli A, Corazziari E, Habib FI, DeMasi E, Bilotti D, Mazarella R, Giubilei D, Fegiz G: Frequencies and cyclical pattern of the human sphincter of Oddi phasic activity. Gut 27:363–396, 1986
Gennen JE: New diagnostic and treatment modalities involving endoscopic retrograde cholangiopancreatography and esophagogastroduodenoscopy. Scand J Gastroenterol 77(suppl):93–106, 1982
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Guelrud, M., Mendoza, S., Rossiter, G. et al. Sphincter of oddi manometry in healthy volunteers. Digest Dis Sci 35, 38–46 (1990). https://doi.org/10.1007/BF01537220
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01537220