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Combined esophageal and gastric ph-metry in healthy volunteers influence of cable through les and effect of misoprostol

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Abstract

In order to evaluate whether combined esophageal and gastric pH-metry is feasible without interference due to the transcardial cable, four 24-hr ambulatory esophageal pH-metries were carried out in seven healthy volunteers in a randomized order. In two studies only one glass electrode was used. It was placed 5 cm above the lower esophageal sphincter. In the two other studies an additional electrode was placed in the corpus region 10 cm below the lower esophageal sphincter. In order to obtain a wide range of pH values, misoprostol (400 μg) was given at 9am and 9:15pm in two studies. In the two other studies placebo was given. Misoprostol exerted only a weak and short-lasting effect on gastric acidity. The four measuring conditions did not differ with respect to medians of esophageal reflux time and duration of single reflux episodes, Kendall's coefficient of concordance yielded a high reproducibility for both variables (P < 0.0025). Thus, combined esophageal and gastric pH-metry is feasible and highly reproducible.

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Authors and Affiliations

  1. Divisions of Gastroenterology, Klinikum Steglitz der FU Berlin, West Germany

    C. Emde MD, T. Cilluffo MD, P. Bauerfeind MD & A. L. Blum MD

  2. Università di Ancona, Italy

    C. Emde MD, T. Cilluffo MD, P. Bauerfeind MD & A. L. Blum MD

  3. Centre Hospitalier Universitaire Vaudois (CHUV/PMU), Lausanne, Switzerland

    C. Emde MD, T. Cilluffo MD, P. Bauerfeind MD & A. L. Blum MD

Authors
  1. C. Emde MD
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  2. T. Cilluffo MD
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  3. P. Bauerfeind MD
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  4. A. L. Blum MD
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Additional information

This work was supported by Swiss National Foundation grant 3.827.0.86 and by Deutsche Forschungsgemeinschaft grant Em 36/1-3.

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Emde, C., Cilluffo, T., Bauerfeind, P. et al. Combined esophageal and gastric ph-metry in healthy volunteers influence of cable through les and effect of misoprostol. Digest Dis Sci 34, 79–82 (1989). https://doi.org/10.1007/BF01536158

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