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Fatal hepatic necrosis associated with parenteral gold therapy

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Summary

Two young black male patients with seronegative rheumatoid arthritis and treated with nonsteroidal antiinflammatory agents developed fulminant hepatic necrosis following the institution of parenteral gold therapy. These cases, reported from different institutions, may represent a severe form of idiosyncratic gold hepatonecrosis. Awareness of the possible association between gold therapy and severe hepatic injury may become increasingly important as oral gold preparations become widely available.

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Authors and Affiliations

  1. Department of Medicine, University of Pittsburgh, 15261, Pittsburgh, Pennsylvania

    Paul B. Watkins MD, Robert Schade MD, A. Scott Mills MD, Robert L. Carithers Jr MD & David H. Van Thiel MD

  2. Department of Medicine and Department of Pathology, Medical College of Virgini, Virginia Commonwealth University, 23298, Richmond, Virginia

    Paul B. Watkins MD, Robert Schade MD, A. Scott Mills MD, Robert L. Carithers Jr MD & David H. Van Thiel MD

Authors
  1. Paul B. Watkins MD
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  2. Robert Schade MD
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  3. A. Scott Mills MD
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  4. Robert L. Carithers Jr MD
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  5. David H. Van Thiel MD
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Watkins, P.B., Schade, R., Mills, A.S. et al. Fatal hepatic necrosis associated with parenteral gold therapy. Digest Dis Sci 33, 1025–1029 (1988). https://doi.org/10.1007/BF01536001

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  • DOI: https://doi.org/10.1007/BF01536001

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