Abstract
The effects of fenfluramine on 21 maladaptive behaviors in 20 autistic individuals were examined over a 9-month period utilizing a double-blind, crossover, placebo-controlled design. Raters carried out time-sampled observations in the school and residence. In addition, videotaped data were collected in controlled settings and assessed by the raters at the conclusion of the study. Some individuals displayed negative side effects such as tension, agitation, insomnia, and sweating during the 16-week period they received fenfluramine. The results demonstrated that fenfluramine caused no significant reductions in maladaptive behaviors. The lack of any significant positive results from this medication and the side effects observed strongly indicate the need for caution in the use of fenfluramine with autistic persons.
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This research was supported by funding from the California Department of Developmental Services, Gary Macomber, Director; Bamford Frankland, Deputy Director; Don Bowling, Chief of Clinical Program Services. The support of Frank Turley, Executive Director, and David Freehauf, Clinical Director of CSH/DC, was appreciated. The authors gratefully acknowledge the assistance of the following individuals: Gary Bazzell, Cathy Davis, Steve Haferkamp, Tracee Parker, Kathryn Peckham, Debra Spiegle, Roger Light, Henry Soper, and Donna Gaier. We are also indebted to the staff of units 64, 66, and 67 for their participation in the study. The A. H. Robins Company supplied the pondimin (fenfluramine) and placebo tablets, which were dispensed by Charles Davis, Pharm. D. We thank Drs. Edward Ritvo, B. J. Freeman, and Aurthur Yuwiler for their assistance.
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Yarbrough, E., Santat, U., Perel, I. et al. Effects of fenfluramine on autistic individuals residing in a state developmental center. J Autism Dev Disord 17, 303–314 (1987). https://doi.org/10.1007/BF01487062
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DOI: https://doi.org/10.1007/BF01487062