Abstract
The effect of growth hormones (GH) on renal growth was measured in growing uremic rats using a five-sixths nephrectomy model and GH, 5 mg/kg per day. At the end of 8 weeks, somatic size was significantly smaller in the untreated uremic rats. The uremic rats given GH were the same size as the non-uremic control animals. Organ size (heart, liver and kidney) differed in that only untreated uremic animals had a significantly smaller kidney weight. Despite a five-sixths nephrectomy, the uremic animals receiving GH had kidneys the same size as shamoperated control animals. Renal function was not changed by GH therapy in either control or uremic animals. DNA content expressed as milligrams per kilogram kidney tissue was low only in the untreated uremic rats. Glomerular volume and proximal tubular area were elevated in both groups of uremic animals but were elevated to a significantly greater degree in those receiving GH. GH given in large doses to growing animals appears to induce both somatic and renal growth.
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References
Powell DR (1988) Renal disease and growth retardation. Growth Genet Horm 4: 1–4
Arnold WC, Danford D, Holliday M (1983) Effects of caloric supplementation on growth in children with uremia. Kidney Int 24: 205–209
Lim V, Kathpaliia SC, Henriquez C (1978) Endocrine abnormalities associated with chronic renal failure. Med Clin 62: 1341–1344
Mehls O, Ritz E (1983) Skeletal growth in experimental uremia. Kidney Int 24: S53-S62
Powell DR, Rosenfeld RG, Sperry JB, Baker BK, Hintz RL (1987) Serum concentrations of insulin-like growth factor (IGF)-I, IGF-2 and unsaturated somatomedin carrier proteins in children with chronic renal failure. Am J Kidney Dis 10: 287–292
Lippe B, Fine RN, Koch VH, Sherman BM (1988) Accelerated growth following treatment of children with chronic renal failure with recombinant human growth hormone (somatrem): a preliminary report. Acta Paediatr Scand 343: 127–131
Labarca C, Paigen K (1980) A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 102: 344–352
Powell DR, Rosenfeld RG, Hintz RL (1988) Effects of growth hormone therapy and malnutrition on the growth in rats with renal failure. Pediatr Nephrol 2: 424–430
Mehls O, Ritz E, Ernst BH, Eggli P, Heinrich U, Zapf J (1988) Improvement of growth and food utilization by human recombinant growth hormone in uremia. Kidney Int 33: 45–52
Nakano M, Kainer G, Foreman J, Daijin K, Chan JC (1989) The effects of exogenous rat growth hormone therapy on growth of uremic rats fed an 8% protein diet. Pediatr Res 26: 204–207
Hirschberg R, Kopple J (1987) Effects of growth hormone on GFR and renal plasma flow in man. Kidney Int 32: 21–24
Miskell CA, Simpson DP (1990) Hyperplasia precedes increased glomerular filtration rate in rat remant kidney. Kidney Int 37: 758–766
Larsson L, Aperia A, Wilton P (1980) Effect of normal development on compensatory renal growth. Kidney Int 18: 29–35
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Arnold, W.C., Shirkey, B., Frindik, P. et al. Effect of growth hormone on kidney growth and glomerular structure. Pediatr Nephrol 5, 529–532 (1991). https://doi.org/10.1007/BF01453695
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DOI: https://doi.org/10.1007/BF01453695