Summary
A case of neurocutaneous melanosis in a 15 year old male is described. A primary malignant meningeal melanoma caused the death of the patient in six months. The skin lesions were benign. The literature is reviewed, and the nature of the disease and its relationship with other phakomatoses is discussed.
Similar content being viewed by others
References
Dasgupta, T. K., Brasfield, R. D., Paglia, M. A., Primary melanomas in unusual sites. Surg. Gynecol. Obstet.128 (1969), 841–848.
Deutsch, S., Mescon, H., Melanin pigmentation and its endocrine control. New. Engl. J. Med.257 (1957), 222–226.
Enriquez, R., Egbert, B., Bullock, J., Haven, W., Primary malignant melanoma of C.N.S. Arch. Pathol.95 (1973), 392–395.
Fox, H., Emery, J. L., Goodbody, R. A., Yates, P. O., Neurocutaneous melanosis. Arch. Dis. Childh.39 (1964), 508–616.
Gibson, J. B., Burrows, D., Weir, W. P., Primary melanoma of the meninge. J. Path. Bact.74 (1957), 419–438.
Harper, C. G., Thomas, D. G., Neurocutaneous melanosis. J. Neurol. Neurosurg. and Psychiat.37 (1974), 760–763.
Hoffman, H. J., Freeman, A., Primary malignant leptomeningeal melanoma in association with giant hairy nevi. Report of two cases. J. Neurosurg.26 (1967), 62–71.
Huning, K. J., Malignant melanoblastosis of the leptomeninx. Beitr. Path.152 (1974), 200–205.
Kiel, F. W., Starr, L. B., Hansen, J. L., Primary melanoma of the spinal cord. J. Neurosurg.18 (1961), 616–629.
Lubarsch, O., Zur vergleichenden Pathologie der melanotischen Gewächse. Med. Klin.16 (1920), 195.
Madonick, M. J., Savitsky, N., Subarachnoid haemorrhage in melanoma of the brain. Arch. Neurol. Psychiat.65 (1951), 628.
Maki, Y., Minei, J., Nakada, Y., Horie, T., Ono,.Y, Primary leptomeningeal melanoma associated with hairy giant nevi. Autopsy case. Brain Nerve21 (1969), 393–401.
Morris, L. L., Danta, G., Malignant cerebral melanoma complicating giant pigmented naevus: a case report. J. Neurol. Neurosurg. Psychiatr.31 (1968), 628–632.
Nathanson, L., Hall, T. C., Farber, S., Biological aspects of human malignant melanoma. Cancer20 (1967), 650–655.
Pack, G. T., Pigmented mole and the malignant melanoma. Cancer12 (1962), 11.
Perkinson, N. G., Melanoma arising in cafe-au-lait spot of neurofibromatosis. Amer. J. Surg.93 (1957), 1018.
Rawles, M. C., Origin of melanophores and their role in development of color patterns in vertebrates. Physiol. Rev.28 (1948), 383.
Reed, W. B., Becker, S. W., Sr., Becker, S. W., Jr., Nickel, W. R., giant pigmented nevi melanoma and leptomeningeal melanocytosis: a clinical and histopathological study. Archs. Derm.91 (1965), 100–119.
Russell, D. S., Rubinstein, L. J., Pathology of tumours of the Nervous System, pp. 40–42. London: Arnold Publ. 1973.
— —, Pathology of tumours of the Nervous System, p. 60. London: Arnold Publ. 1973.
Russell, J. L., Reyes, R. G., Giant pigmented nevi. JAMA171 (1959), 2083–2087.
Roca de Viñals, R., Elizalde Armendariz, C., Coma Fabrés, A., Tumores melánicos del S.N.C.A. propósito de tres casos clínicos. Med. Clin. (Barcelona)22 (1954), 304–311.
Savitz, M. H., Anderson, P. J., Primary melanoma of the leptomeninges: A review. Mount Sinai J. Med.41 (1974), 774–791.
—, Gendelman, S., Huang, Y. P., Fayemi, A. O., Anderson, P. J., Primary leptomeningeal melanomatosis. Mount Sinai J. Med.41 (1974), 622–630.
Saxen, L., Saxen, E., Malignant embryoma of the neural crest. Cancer13 (1960), 899–906.
Scott, M., Ferrara, V. L., Peale, A. R., Multiple melanotic meningiomas of the cervical cord. Case report. J. Neurosurg.34 (1971), 555–559.
Slam, R., Primary malignant melanoma of the cerebellum. J. Path. Bact.94 (1967), 196–200.
Slaughter, J. C., Hardman, J. M., Kempe, L. G., Earle, K. M., Neurocutaneous melanoisis and leptomeningeal melanomatosis in children. Arch. Path.88 (1969), 298–304.
Stowens, D., Lin, T. H., Melanotic progonoma of the brain. Hum. Pathol.5 (1974), 105–113.
Tveten, L., Primary meningeal melanosis. A clinicopathological report of two cases. Acta Path. Microbiol. Scand.63 (1965), 1–10.
Van Bogaert, L., La mélanose neurocutanés diffuse hèredo-familials. Bull. Acad. Roy. Méd. Belg.13 (1948), 397–428.
Virchow, R., Pigment und diffuse Melanose der Arachnoides. Virchow's Arch. Path. Anat. Physiol.16 (1859), 180–187.
Willis, R. A., Pathology of tumours, 3rd. ed., pp. 917–918. London: Butterworths. 1960.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lamas, E., Lobato, R.D., Sotelo, T. et al. Neurocutaneous melanosis. Acta neurochir 36, 93–105 (1977). https://doi.org/10.1007/BF01405990
Issue Date:
DOI: https://doi.org/10.1007/BF01405990