Skip to main content
SpringerLink
Log in

End-results of experimental gastroschisis created by abdominal wall versus umbilical cord defect

  • Original Article
  • Published:
Pediatric Surgery International Aims and scope Submit manuscript

Abstract

An experimental study was conducted to determine the end-results of two different defects on the anterior abdominal wall: an abdominal wall defect (AWD) versus an umbilical cord defect (UCD) using chick embryos. The AWD was created by leaving an intact skin bridge between the defect and the umbilical cord in group l; the UCD was created on the umbilical cord near the junction of the skin in group 2. At the end of incubation, the intestines appeared hemorrhagic in the AWD group, but not in the UCD group. During microscopic examination, hemorrhagic areas were observed in the bowel wall and mucosal villi in the AWD group but not in the UCD group. The end-result of the defect causing the physiological umbilical hernia resulted in bowel damage resembling the classic picture of gastroschisis (GS). We conclude that the site of the defect in GS is not the abdominal wall itself, but the physiological umbilical hernia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Adzick NC, Longaker MT (1992) Scarless fetal healing. Ann Surg 215: 1–7

    PubMed  Google Scholar 

  2. Aktuĝ T, Erdaĝ G, Kargi A, et al (1995) Amnioallantoic fluid exchange for the prevention of intestinal damage in gastroschisis: an experimental study on chick embryos. J Pediatr Surg 30: 384–387

    PubMed  Google Scholar 

  3. Amoury RA, Beatty EC, Wood WG, et al (1988) Histology of the intestine in human gastroschisis — relationship to intestinal malfunction: dissolution of the peel and its ultrastructural characteristics. J Pediatr Surg 23: 950–956

    PubMed  Google Scholar 

  4. Burrington JD (1971) Wound healing in the fetal lamb. J Pediatr Surg 22: 640–645

    Google Scholar 

  5. de Vries P (1980) The pathogenesis of gastroschisis and omphalocele. J Pediatr Surg 15: 245–251

    PubMed  Google Scholar 

  6. Duhamel B (1963) Embryology of exomphalos and allied malformations. Arch Dis Child 38: 142–147

    Google Scholar 

  7. Glick PL, Harrison MR, Adzick NC, et al (1985) The missing link in pathogenesis of gastroschisis. J Pediatr Surg 20: 406–409

    PubMed  Google Scholar 

  8. Harrison MR, Langer JC, Adzick NS, et al (1990) Correction of congenital diaphragmatic hernia in utero: V. Initial clinical experience. J Pediatr Surg 25: 47–51

    PubMed  Google Scholar 

  9. Johnson N, Lilford RJ, Irving H, Crabbe D, Cartmill R (1991) The vanishing bowel. Case report of bowel atresia following gastroschisis. Br J Obstet Gynaecol 98: 214–215

    PubMed  Google Scholar 

  10. Klück P, Tibboel D, van der Kamp AWM, et al (1983) The effect of fetal urine on the development of the bowel in gastroschisis. J Pediatr Surg 18: 47–50

    PubMed  Google Scholar 

  11. Longaker MT, Adzick NC (1991) The biology of fetal wound healing: a review. Plast Reconstr Surg 87: 788–789

    PubMed  Google Scholar 

  12. Longaker MT, Whitby DJ, Jennings RW, et al (1991) Fetal diaphragmatic wounds heal with scar formation. J Surg Res 50: 375–85

    PubMed  Google Scholar 

  13. Lopez de Torre, Tovar JA, Uriarte S, et al (1991) Transperitoneal exchanges of water and solutes in the fetus with gastroschisis. Experimental study in the chick embryo. Eur J Pediatr Surg 1: 346–352

    PubMed  Google Scholar 

  14. Lopez de Torre, Tovar JA, Uriarte S, et al (1992) The nutrition of the fetus with intestinal atresia: studies in the chick embryo model. J Pediatr Surg 27: 1352–1328

    PubMed  Google Scholar 

  15. Meuli M, Lorenz HP, Hedrick MH, et al (1995) Scar formation in the fetal alimentary tract. J Pediatr Surg 30: 392–401

    PubMed  Google Scholar 

  16. Perrella RR, Ragavendra N, Tessler FN, et al (1991) Fetal abdominal wall mass detected on prenatal sonography: Gastroschisis vs omphalocele. AJR 157: 1065–1068

    PubMed  Google Scholar 

  17. Shaw A (1975) The myth of gastroschisis. J Pediatr Surg 10: 235–244

    PubMed  Google Scholar 

  18. Somasundaram K, Prathap K (1970) Intra-uterine healing of the skin wounds in rabbit fetuses. J Pathol 100: 81–86

    PubMed  Google Scholar 

  19. Srinathan SK, Langer JC, Blennerhassett MG, et al (1995) Etiology of intestinal damage in gastroschisis III: morphometric analysis of the smooth muscle and submucosa. J Pediatr Surg 30: 379–383

    Google Scholar 

  20. Thomas DFM, Atwell JD (1976) The embryology and surgical management of gastroschisis. Br J Surg 63: 893–897

    PubMed  Google Scholar 

  21. Tibboel D, Klück P, Molenaar JC, Gaillard JL (1987) A comparative investigation of the bowel wall in gastroschisis and omphalocele: relation to postoperative complications. Pediatr Pathol 7: 277–285

    PubMed  Google Scholar 

  22. Tibboel D, Klück P, Van der Kamp AWM, et al (1985) The development of the characteristic anomalies found in gastroschisis — experimental and clinical data. Z Kinderchir 40: 355–360

    PubMed  Google Scholar 

  23. Tibboel D, Raine P, McNee M, et al (1986) Developmental aspects of gastroschisis. J Pediatr Surg 21: 865–869

    PubMed  Google Scholar 

  24. Tibboel D, Vermey-Keers C, Klock P, et al (1985) The natural history of gastroschisis during fetal life: development of fibrous coating on the bowel loops. Teratology 33: 267–272

    Google Scholar 

Download references

Author information

Author notes

  1. T. Aktuĝ

    Present address: Dokuz Eylül Üniversitesi Tip Fakilltesi, Çocuk Cerrahisi Anabilim Dali, 35340, Balçova/İzmir, Turkey

Authors and Affiliations

  1. Department of Pediatric Surgery, Dokuz Eylül University, Medical Faculty, İzmir, Turkey

    T. Aktuĝ, M. Hoşgör, F. M. Akgür & M. Olguner

  2. Department of Pathology, Dokuz Eylül University, Medical Faculty, İzmir, Turkey

    A. Kargi

  3. Department of Pediatric Surgery, Sophia Children's Hospital, Erasmus University, Rotterdam, The Netherlands

    D. Tibboel

Authors
  1. T. Aktuĝ
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Hoşgör
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. M. Akgür
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Olguner
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Kargi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. D. Tibboel
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aktuĝ, T., Hoşgör, M., Akgür, F.M. et al. End-results of experimental gastroschisis created by abdominal wall versus umbilical cord defect. Pediatr Surg Int 12, 583–586 (1997). https://doi.org/10.1007/BF01371904

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01371904

Key words

Search

Navigation