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Effects of pancreatic polypeptide and vasoactive intestinal polypeptide on rat ileal and colonic water and electrolyte transportin vivo

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Abstract

Two gastrointestinal peptides, vasoactive intestinal polypeptide (VIP) and pancreatic polypeptide, suspected of being associated with symptoms of WDHA syndrome (pancreatic cholera) were tested on the rat small and large intestine for their effects on water and electrolyte transport. Intravenous infusion of VIP (14.3 μg/kg/hr) inhibited net absorption of water and electrolytes in the ileum and reversed net absorption to net secretion in the colon. In contrast, bovine pancreatic polypeptide (52 μg/kg/hr) did not inhibit absorption or stimulate secretion. These data indicate VIP causes colonic secretionin vivo, an effect previously shown onlyin vitro, and that bovine pancreatic polypeptide (at this dose) is not a secretagogue in the small or large intestine of the rat. Thus, while consistent with VIP being a contributory agent to the secretion of pancreatic cholera, the data do not support the notion that pancreatic polypeptide might be a causative agent in this syndrome.

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Authors and Affiliations

  1. Division of Pharmacology, College of Pharmacy, and Department of Medicine, Ohio State University, 500 W. 12 Ave, 43210, Columbus, Ohio

    Z. C. Wu BS, T. M. O'Dorisio MD, S. Cataland MD, H. S. Mekhjian MD &  T. S. Gaginella PhD

Authors
  1. Z. C. Wu BS
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  2. T. M. O'Dorisio MD
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  3. S. Cataland MD
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  4. H. S. Mekhjian MD
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  5. T. S. Gaginella PhD
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Additional information

This work was supported in part by NCI Grant CA 16058-05 and funds from the graduate school of the Ohio State University. Dr. Gaginella is the recipient of Research Career Development Award 1 KO4 AM 00471-01 from the National Institute of Arthritis, Metabolism and Digestive Diseases. Dr. O'Dorisio is recipient of a Clinical Associate Physician Award (NIH-GCRC, RR-34).

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Wu, Z.C., O'Dorisio, T.M., Cataland, S. et al. Effects of pancreatic polypeptide and vasoactive intestinal polypeptide on rat ileal and colonic water and electrolyte transportin vivo . Digest Dis Sci 24, 625–630 (1979). https://doi.org/10.1007/BF01333707

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