References
Matter A, Orci L, Rouiller C: A study on the permeability barriers between Disse's space and the bile canaliculi. J Ultrastruc Res, Suppl 11, 1969
Lowenstein W, Penn R: Intercellular communication and tissue growth. II. Tissue regeneration. J Cell Biology, 33:235–242, 1967
Rappaport AM: Anatomic considerations.In Diseases of the Liver, L Schiff (ed). Philadelphia, JB Lippincott Co, 1969, pp 1–49
Ohtani O, Murakami T: Peribiliary portal system in the rat liver as studied by the injection replica SEM method.In Scanning Electron Microscopy, O Johari, I Corvin (eds). Chicago, IIT Research Institute, 1978, pp 241–244
Jones AL, Mill ES: The liver and gallbladder.In Histology, 4th ed, L Weiss, RO Greep (eds). New York, McGraw-Hill, 1977, pp 701–747
Loud AV: A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells. J Cell Biol 37:27–46, 1968
Jones AL, Schmucker DL, Mooney JS, Adler RD, Ockner RK: Morphometric analysis of rat hepatocytes after total biliary obstruction. Gastroenterology 71:1050–1060, 1976
Jungermann K, Sasse D: Heterogeneity of liver parenchymal cells. Trends Biochem Sci 3:198–202, 1978
Grisham JW: A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver: Autoradiography with thymidine-H3. Cancer Res 22:842–849, 1962
Den Otter W, Truit G: Causes of the zonal distribution of glycogen in the liver acinus after a fat-rich diet. I. Glycogen deposition in the acni of rat livers during “normal” and “reversed” perfusion. Anat Rec 173:325–332, 1972
Miller DL, Zanolli CS, Gumucio JJ: Quantitative morphology of the sinusoids of the hepatic acinus. Gastroenterology 76:965–969, 1979
Goresky CA, Bach GG, Nadeau BE: The uptake of materials by the intact liver: Transport and removal of galactose. J Clin Invest 52:991–1009, 1973
Gumucio JJ, Katz ME: The acinar organization for bile salt transport.In The Liver, Third International Gstaad Symposium, R Preisig, J Bircher (eds). Editio Cantor Aulendorf, 1978, pp 179–184
Spenney JG, Tobin MM, Mikas AA, Gibson RG, Hirschowitz BI, Johnson BJ, Tauxe WN: Utilization of a radioiodinated bile salt for kinetic studies and hepatic scintigraphy. Gastroenterology 76:272–278, 1979
Grandjean EM, Karlaganis G, Noelpp U, Huegli H, Paumgartner G: Hepatic handling of123I-cholylglycylhistamine, a neutral bile salt derivative.In The Liver, Third International Gstaad Symposium, R Preisig, J Bircher (eds). Editio Cantor Aulendorf, 1978. pp 255–262
Jones AL, Hradek GT, Renston RH, Wong KY, Karlaganis G, Paumgartner G: Autoradiographic evidence for a hepatic lobular concentration gradient of a bile acid derivative. Am J Physiol 238:G233–237, 1980.
Jones AL, Schmucker DL, Mooney JS, Adler RD, Ockner RK: A quantitative analysis of hepatic ultrastructure in rats during enhanced bile secretion. Anat Rec 192:272–287, 1978
Jones AL, Schmucker DL, Mooney JS, Ockner RK, Adler RD: Alterations in hepatic pericanalicular cytoplasm during enhanced bile secretory activity. Lab Invest 40:512–517, 1979
Schmucker DL, Mooney JS, Jones AL: Stereological analysis of hepatic fine structure in the Fisher 344 rat. Influence of sublobular location and animal age. J Cell Biol 78:319–337, 1978
Jones AL, Mills ES: Ultrastructural contributions to molecular pharmacology.In Modern Pharmacology Vol 1, Part 1, RM Featherstone (ed). New York, Marcel Dekker, 1973, pp 83–146
Bjorkhem I, Danielsson H, Wikvall K: 7α-Hydroxylation of cholesterol by reconstituted systems from rat liver microsomes. Biochem Biophy Res Commun 61:934–941, 1974
Layden TJ, Boyer JL: Bile acids influence bile canalicular membrane morphology and the lobular gradient in canalicular size. Lab Invest 39:110–119, 1978
Palay SL, Karlin LJ: An electron microscopic study of the intestinal villus II. The pathway of fat absorption. J Biophys Biochem Cytol 5:373–401, 1959
Jones AL, Schmucker DL, Espinosa E: Unpublished observations
Boyer JL, Itabashi M, Hruban Z: Formation of pericanalicular vacuoles during sodium dehydrocholate choleresis—a mechanism for bile acid transport.In The Liver, Third International Gstaad Symposium, R Preisig, J Bircher (eds). Editio Cantor Aulendorf, 1978, pp 163–178
Erlinger S, Dubin M, Maurice M, Feldmann G: Modification of bile secretion induced by phalloidin and colchicine in the rat:In The Liver, Third International Gstaad Symposium, R Preisig, J Bircher (eds). Editio Cantor Aulendorf, 1978, pp 192–196
French SW, Davies PL: Ultrastructural localization of actin-like filaments in rat hepatocytes. Gastroenterology 68:765–774, 1975
Jeanrenaud B, Prentki M. Chaponnier CH, Gabbiani G: Cell shape and secretory processes in isolated rat hepatocytes: Effect of actin microfilaments.In The Liver, Third international Gstaad Symposium, R Preisig, J Bircher (eds). Editio Cantor Aulendorf, 1978, pp 56–62
Gregory DH, Vlahcevic ZR, Prugh M, Swell L: Mechanism of secretion of biliary lipids: Role of a microtubular system in hepatocellular transport of biliary lipids in the rat. Gastroenterology 74:93–100, 1978
Phillips MJ, Oda M, Mak E, Fisher MM, Jeejeebhoy KN: Microfilament dysfunction as a possible cause of intrahepatic cholestasis. Gastroenterology 69:48–58, 1975
Oda M, Phillips MJ: Bile canalicular membrane pathology in cytochalasin B-induced cholestasis. Lab Invest 37:350–356, 1977
Dubin M, Maurice M, Feldmann G, Erlinger S: Phalloidin induced cholestasis in the rat: Relation to changes in microfilaments. Gastroenterology 75:450–455, 1978
Caro LG, Palade GE: Protein synthesis, storage and discharge in the pancreatic exocrine cell. An autoradiographic study. J Cell Biol 20:473–496, 1964
Claude A: Growth and differentiation of cytoplasmic membranes in the course of lipoprotein granule synthesis in the hepatic cell. J Cell Biol 47:745–766, 1970
Jones AL, Ruderman NB, Herrera MG: Electron microscopic and biochemical study of lipoprotein synthesis in the isolated perfused rat liver. J Lipid Res 8:429–446, 1967
Hamilton RL, Regen DM, Gray ME, LeQuire VS: Lipid transport in liver: 1. Electron microscopic identification of very low density lipoproteins in perfused rat liver. Lab Invest 16:305–319, 1967
Peters T, Fleischer B, Fleischer S: The liposynthesis of rat serum albumin IV. J Biol Chem 246:240–244, 1971
Schachter H, Sabbal I, Hudgin RL, Pinteric L: Intracellular localization of liver sugar nucleotide glycoprotein glycosyltransferases in a Golgi-rich fraction. J Biol Chem 245:1090–1100, 1970
Jones AL, Schmucker DL: Current concept of liver structure as related to function. Gastroenterology 73:833–851, 1977
Cramer W, Ludford RJ: On the cellular mechanism of bile secretion and its relation to the Golgi apparatus of the liver cell. J Physiol 62:74–80, 1926
Schmucker DL, Jones AL: Hepatic fine structure in young and aging rats treated with oxandrolone: A morphometric study. J Lipid Res 16:143–150, 1975
Kaga A: Morphogenesis of intrahepatic bile duct of the human fetus. Z Anat Entwicklungsgesch 135:156–184, 1971
Novikoff AB: The endoplasmic reticulum: A cytochemists'view (a review). Proc Natl Acad Sci USA 73:2781–2787, 1976
Novikoff PM, Yam A: Sites of lipoprotein particles in normal rat hepatocytes. J Cell Biol 76:1–11, 1978
deDuve C, Wattiaux GR: Functions of lysosomes. Ann Rev Physiol 28:435–492, 1966
Castle JD, Jamieson JD, Palade GE: Radioautographic analysis of the secretory process in the parotid gland during the secretory cycle. J Cell Biol 53:290–311, 1972
Jones AL, Ockner RK: An electron microscopic study of endogenous very low density lipoprotein production in the intestine of rat and man. J Lipid Res 12:580–589, 1971
Owen RL: Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer's patches in the normal unobstructed mouse intestine: An ultrastructural study. Gastroenterology 72:440–451, 1977
Steer CJ, Clarenburg R: Unique distribution of glycoprotein receptors on parenchymal and sinusoidal cells of rat liver. J Biol Chem 254:4457–4461, 1979
Renston RH, Maloney DG, Jones AL, Hradek GT, Wong KY, Goldfine ID: The bile secretory apparatus: evidence for a vesicular transport mechanism for proteins in the rat, using horseradish peroxidase and125I-insulin. Gastroenterology 78:1373–1388, 1980
Thomas P, Summers J: The biliary excretion of circulating asialoglycoproteins in the rat. Biochem Biophys Res Commun 80:335–339, 1978
Mullock B, Dobrota M, Hinton R: Sources of protein in rat bile. Biochem Biophys Acta 543:497–507, 1978
Goldfine ID, Jones AL, Hradek GT, Wong KY, Mooney JS: Entry of insulin into human cultured lymphocytes: Electron microscopic analysis. Science 202:760–763, 1978
Jones AL, Renston RH, Schmucker DL, Mooney JS, Ockner RK, Adler RD: A morphologic evaluation of the pericanalicular cytoplasm in the rat hepatocyte: Demonstrating possible components of the bile secretory apparatus.In The Liver, Third International Gstaad Symposium. R Preisig, J Bircher (eds). Editio Cantor Aulendorf. 1978, pp 63–70
Goldfine ID, Wong KY, Korc M, Hradek G, Jones AL: Entry of insulin into target cells: EM autoradiographic studiesin vitro andin vivo. J Cell Biol 79:194a, 1978
Bergeron J, Sikstrom R, Hand A, Posner B: Binding and uptake of125I-insulin into rat liver hepatocytes and endothelium. Anin vivo radioautographic study. J Cell Biol 80:427–443, 1979
Bailey C, Flatt P, Atkins T, Matty A: Immunoreactive insulin in bile and pancreatic juice of rat. Endocrinol Exp 10:101–111, 1976
Henderson J: Insulin in body fluids other than blood. Physiol Rev 54:1–22, 1974
Tomasi TB, Bienenstock J: Secretory immunoglobulins. Adv Immunol 9:1–96, 1968
Brown WR: Relationships between immunoglobulins and the intestinal epithelium. Gastroenterology 75:129–138, 1978
Poger ME, Lamm ME: Localization of free and bound secretory component in human intestinal epithelial cells. A model for the assembly of secretory IgA. J Exp Med 139:629–642, 1974
Brandtzaeg P: Mucosal and glandular distribution of immunoglobulin components. Differential localization of free and bound SC in secretory epithelial cells. J Immunol 112:1553–1559, 1974
Brantzaeg P, Baklien K: Intestinal secretion of IgA and IgM: a hypothetical model.In Immunology of the Gut. Vol 46. Ciba Foundation symposium. Amsterdam. Elsevier, 1977, pp 77–113
Lemaitre-Coelho I, Jackson GDF, Vaerman JP: Rat bile as a convenient source of secretory IgA and free secretory component. Eur J Immunol 7:588–590, 1977
Fisher MM, Nagy B, Bazin H, Underdown BJ: Biliary transport of IgA: Role of secretory component. Proc Natl Acad Sci USA 76:2008–2012, 1979
Renston RH, Jones AL, Christiansen WD, Hradek GT, Underdown BJ: Evidence for a vesicular transport mechanism in hepatocytes for biliary secretion of immunoglobulin-A. Science 208:1276–1278, 1980
Orlans E, Peppard J, Reynolds J, Hall J: Rapid active transport of immunoglobulin A from blood to bile. J Exp Med 147:588–592, 1978
Smith PD, Nagura H, Brown WR: IgA in human bile and liver. Gastroenterology 76:1251, 1979
Kakis G, Yousef I: Protein composition of rat bile. Can J Biochem 56:287–290, 1978
Fromter E, Diamond J: Route of passive ion permeation in epithelia. Nature (London), New Biol 235:9–13, 1972
Friend DS, Gilula NB: Variations in tight and gap junctions in mammalian tissues. J Cell Biol 53:758–776, 1972
Schatzki PF: The passage of radioactive lanthanum from the biliary to the vascular system. An electron microscopic and radioactive tracer study. Z Zellforsch. Mikrosk Anat 119:451–459, 1971
Layden TJ, Elias E, Boyer JL: Bile formation in the rat. The role of the paracellular shunt pathway. J Clin Invest 62:1375–1385, 1978
Metz J, Bressler D: Reformation or gap and tight junctions in regenerating liver after cholestasis. Cell Tissue Res 199:257–270, 1979
Boyer JL, Reno D: Properties of Na+, K+-activated ATPase in rat liver plasma membranes enriched with bile canaliculi. Biochem Biophys Acta 401:59–72, 1975
Reichen J, Paumgartner G: Relationship between bile flow and Na+, K+-adenosinetriphosphatase in liver plasma ATPase in rat liver plasma membranes enriched with bile membranes enriched in bile canaliculi. J Clin Invest 60:429–434, 1977
Wannagat FJ, Adler RD, Ockner RK: Bile acid-induced increase in bile acid-independent flow and plasma membrane NaK-ATPase activity in rat liver. J Clin Invest 61:297–307, 1978
Blitzer BL, Boyer JL: Cytochemical localization of Na+, K+-ATPase in the rat hepatocyte. J Clin Invest 62:1104–1108, 1978
Layden TJ, Schwarz J, Boyer JL: Scanning electron microscopy of the rat liver. Studies of the effect of taurolithocholate and other models of cholestasis. Gastroenterology 69:724–738, 1975
Hampton JC: Electron microscopic study of extrahepatic biliary obstruction in the mouse. Lab Invest 10:502–513, 1961
Forker EL: Mechanisms of hepatic bile formation. Ann Rev Physiol 39:323–347, 1977
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Jones, A.L., Schmucker, D.L., Renston, R.H. et al. The architecture of bile secretion. Digest Dis Sci 25, 609–629 (1980). https://doi.org/10.1007/BF01318875
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DOI: https://doi.org/10.1007/BF01318875