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Does Ca2+ channel blockade modulate the antidepressant-induced changes in mechanisms of adrenergic transduction?

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Summary

We investigated how the L-type calcium channel blockade (CCB) with nifedipine affects the cyclic AMP responses to noradrenaline or isoproterenol in cerebral cortical slices from rats receiving antidepressant treatments that induce (electroconvulsive shock, imipramine) or do not induce (amitriptyline) β-downregulation. To assess the role of protein kinase C (PKC) in receptor crosstalk under CCB conditions, the cyclic AMP responses were tested also in the presence of a PKC activator, TPA. CCB alone induced no changes, but modulated the action of those antidepressants that down regulate the β-adrenergic system. Chronic ECS and imipramine treatments were differently affected. ECS, under conditions of CCB, down regulated the response to isoproterenol in the presence of TPA, while imipramine ceased to block the TPA-potentiation of cyclic AMP responses. Thus, CCB affects the processes related to the antidepressant-induced changes on the crosstalk between α1- and β-adrenergic receptors, depending on the specific properties of the antidepressant.

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  1. I. Nalepa

    Present address: Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland

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  1. Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland

    M. Kowalska, G. Kreiner & J. Vetulani

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  1. I. Nalepa
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  2. M. Kowalska
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  3. G. Kreiner
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  4. J. Vetulani
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Nalepa, I., Kowalska, M., Kreiner, G. et al. Does Ca2+ channel blockade modulate the antidepressant-induced changes in mechanisms of adrenergic transduction?. J. Neural Transmission 104, 535–547 (1997). https://doi.org/10.1007/BF01277670

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  • DOI: https://doi.org/10.1007/BF01277670

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