Summary
The importance of malnutrition as major cause of morbidity and mortality in cancer patients is well documented. It has been shown that nutritional therapy improves well-being and nutritional status of the patient, but the tumor can also be accelerated by hypercaloric nutrition. Our study does not confirm the induction of tumor growth. A high positive metabolic rate of the host lowers the tumor's growth rate and its tendency to spread. The retention of nitrogen in host increase with decreasing rate of energy and nutrition. Our results show that the tumor itself uses energy and nutrients from host cell catabolism and does not directly exploit exogenous nutrient substrates. It should not be forgotten that the animal model leads to specific changes affecting the energy and nutrient metabolism.
Zusammenfassung
Die Mangelernährung bei Tumorpatienten kann als auslösender Faktor von Morbidität and Mortalitat angesehen werden. Eine entgegensteuernde Ernahrungstherapie steigert das Wohlbefmden des Patienten, es kann aber auch den Tumor zu einem Wachstumsschub anregen. Unsere Studie bestätigt die Induktion des Tumorwachstums nicht. Die Große des Tumors war um so kleiner und kompakter, je größer das Energie- and Nährstoffangebot ist. Die Stickstoffretention im Malignomträger nimmt mit sinkendem Energie und Nährstoffangebot zu. Deshalb kann vermutet werden, daß das Malignom seinen Energie- and Nährstoffbedarf aus dem Katabolismus des Wirtes bezieht and nicht aus exogen angebotenen Energie und Nährstoffträgern. Vergessen werden dürfen dabei nicht die Besonderheiten des Tiermodells.
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Brenner, U., Wolters, U., Kirchner, B. et al. Die Stickstoff bilanz zwischen Malignom und Wirt im Tiermodell. Langenbecks Arch Chiv 374, 111–117 (1989). https://doi.org/10.1007/BF01261620
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DOI: https://doi.org/10.1007/BF01261620