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Junín virus encephalitis in mice: Its inhibition by antithymocyte serum

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Summary

Brain tissues of newborn mice infected intracerebrally with Junin virus were examined by light and electron microscopy in order to elucidate the pathogenesis of Junin virus infection as well as the effect of antithymocyte serum (ATS) on the development of the disease.

The most prominent brain lesions caused by Junin virus in mice consisted in microglial activation, perivascular cuffs with mononuclear cells and demyelinating processes. Animals pretreated with ATS and subsequently infected with Junín virus showed no neurologic disorders and only minimal or no lesions in their brain.

It is concluded that Junin virus encephalitis might have an immunological basis similar to that described in experimental allergic encephalitis. This assumption is supported by the inhibiting effect of ATS which is known to be a potent suppressor of delayed type hypersensitivity.

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Authors and Affiliations

  1. Cátedra de Microbiología y Parasitología, Facultad de Medicina, Universidad de Buenos Aires, Rep. Argentina

    Ana Lía Taratuto, Lidia Z. Tkaczevski (Miembro de la Carrera del Investigador Científico del Conicet), Nora Ruth Nota (Miembro de la Carrera del Investigador Científico del Conicet), Marta R. Nejamkis & Octavio A. Giovanniello (Becario del Conicet)

  2. Centro de Investigaciones Neurológicas del Instituto di Tella, Hospital de Niños de Buenos Aires, Rep. Argentina

    Ana Lía Taratuto, Lidia Z. Tkaczevski (Miembro de la Carrera del Investigador Científico del Conicet), Nora Ruth Nota (Miembro de la Carrera del Investigador Científico del Conicet), Marta R. Nejamkis & Octavio A. Giovanniello (Becario del Conicet)

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  1. Ana Lía Taratuto
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  2. Lidia Z. Tkaczevski
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  3. Nora Ruth Nota
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  4. Marta R. Nejamkis
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  5. Octavio A. Giovanniello
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Taratuto, A.L., Tkaczevski, L.Z., Nota, N.R. et al. Junín virus encephalitis in mice: Its inhibition by antithymocyte serum. Archiv f Virusforschung 43, 173–183 (1973). https://doi.org/10.1007/BF01250412

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  • DOI: https://doi.org/10.1007/BF01250412

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