Summary
In contrast with the Schmidt-Ruppin strain of RSV, Bryan strains are not oncogenic for ducks. From the Bryan standard strain (BS-RSV) a variant virus oncogenic for ducks was isolated by passing BS-RSV through cortisone-treated ducklings together with chick embryonic tissues. From the Bryan high titer strain (BH-RSV) such a variant virus could not be isolated. The variant virus (BK-RSV) is also oncogenic for mice and hamsters, whereas parent strain lacks such oncogenicity for mammals. Thus, there may be some correlation between oncogenicity for ducks and mammals. Mouse or hamster tumors induced by the BK strain did not produce infectious RSV eitherin vivo orin vitro. However, when hamster tumor cells in appropriate amounts were inoculated in the wing web of chickens, sarcomas were induced yielding infectious RSV. Thus, the RSV genome persists in BK-induced mammalian tumor cells and is able to produce infectious virus in the presence of chicken cells.
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Kuwata, T., Kawakami, H. Isolation of a variant strain of Rous sarcoma virus oncogenic for ducks and mammals. Archiv f Virusforschung 32, 1–12 (1970). https://doi.org/10.1007/BF01241513
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DOI: https://doi.org/10.1007/BF01241513