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Urinary endothelin excretion in the neonate: influence of maturity and perinatal pathology

  • Proceedings of the Fifth International Workshop on Developmental Renal Physiology (Part II) August 26–28, 1992 Tremezzo, Italy
  • Original Article
  • Published:
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Abstract

The present study was undertaken to establish the developmental pattern of urinary endothelin-1 (ET-1) excretion and to define its possible role in mediating pathophysiological changes related to perinatal asphyxia/infection and dopamine treatment. Urinary ET-1 levels were measured by radioimmunoassay in 7 full-term neonates (mean gestational age 39.3 weeks) on days 1, 3 and 5, and in 9 pre-term neonates (mean gestational age 30.8 weeks) on days 1, 3, 5, 7 and weekly thereafter for 5 consecutive, weeks. The results were compared with those of three age-groups of 30 normal children (4–8 years, 9–12 years and 13–18 years); each group, consisted of 10 children. The influence of severe cardiopulmonary distress (n=16, mean gestational age 33.9 weeks, post-natal age 3.3 days) and dopamine administration in a dose of 2 μg/min per kg (n=10, mean gestational and post-natal ages 32.1 weeks and 5.6 days, respectively) were also studied. In full-term infants, ET-1 concentration fell from 34.3±1.8 pmol/l on day 1 to 21.5±1.5 pmol/l on day 5 (P<0.01). In premature infants its absolute value and its post-natal fall were similar in the 1st week and no further change occurred in weeks 2–5; it stabilized at levels between 17.1±2.2 and 16.7±1.7 pmol/l. These concentrations tended to be lower than those of 25.5±1.3, 23.0±1.0 and 26.2±0.7 pmol/l measured in three groups of older children. During the 1st week, daily ET-1 excretion remained unchanged in term infants (3.1±1.0 vs. 3.7±1.5 pmol/m2 per day), but there was a significant increase from 6.5±1.0 to 12.4±0.7 pmol/m2 per day (P<0.01) in premature infants. During weeks 2–5, preterm infants excreted more ET-1 than older children (P<0.01). In response to perinatal ashphyxia/infection and dopamine therapy, urinary ET-1 excretion markedly rose and there was a significant positive correlation between urine flow rate and ET-1 excretion (P<0.001). We conclude that ET-1 concentration rather than excretion rate may have a role in mediating the changes in renal functions that occur soon after birth. The pathophysiological significance of the flow-dependent increase in urinary ET-1 excretion needs to be further studied.

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Authors and Affiliations

  1. County Children's Hospital, Box-76, H-7601, Pécs, Hungary

    Endre Sulyok & Tibor Ertl

  2. Department of Paediatrics, University Medical School, Pécs, Hungary

    Károly Adamovit

  3. Department of Obstetrics and Gynaecology, Semmelweis University, Budapest, Hungary

    Sarolta Hovanyovszky

  4. University Children's Hospital, Giessen, Germany

    Wolfgang Rascher

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  1. Endre Sulyok
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  2. Tibor Ertl
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  4. Sarolta Hovanyovszky
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  5. Wolfgang Rascher
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Sulyok, E., Ertl, T., Adamovit, K. et al. Urinary endothelin excretion in the neonate: influence of maturity and perinatal pathology. Pediatr Nephrol 7, 881–885 (1993). https://doi.org/10.1007/BF01213378

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  • DOI: https://doi.org/10.1007/BF01213378

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