Abstract
The disposition kinetics and cumulative urinary excretion of sulfamethazine were compared in goats fed normally (control) and following a 72-hour period of starvation (fasting). The only pharmacokinetic parameter which showed a statistically significant difference between the two groups was the body (systemic) clearance. This decreased from 2.26±0.28 ml/min· kg (\(\bar x\) ±SD, n=6) in the control group to 1.16±0.54 ml/min·kg in the fasting group (p<0.01). Since the apparent volume of distribution was not affected by starvation, the decreased clearance was attributed to slower metabolism of the drug. Because of the analytical method used to measure sulfamethazine concentrations in plasma and urine, no conclusion could be drawn as to whether the rates of hydroxylation or of acetylation, or both metabolic pathways were decreased in the starved condition.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Abdullah, A. S. & Baggot, J. D. 1986. Effect of short term starvation on disposition kinetics of chloramphenicol in goats.Research in Veterinary Science,40, 382–385
Baggot, J. D. 1976.Principles of Drug Disposition in Domestic Animals, (W. B. Saunders, Philadelphia), pp. 144–189
Bevill, R. F., Dittert, L. W. & Bourne, D. W. A. 1977. Disposition of sulfonamides in food-producing animals. IV. Pharmacokinetics of sulfamethazine in cattle following administration of an intravenous dose and three oral dosage forms.Journal of Pharmaceutical Science,66, 619–623
Bratton, A. C. & Marshall, E. K. 1939. A new coupling component for sulphanilamide determination.Journal of Biological Chemistry,128, 537–550
Nawaz, M. & Khan, F. H. 1979. Pharmacokinetics and urinary excretion of sulphadimidine in sheep and goats.Journal of Veterinary Pharmacology & Therapeutics,2, 129–132
Nawaz, M. & Nawaz, R. 1983. Pharmacokinetics and urinary excretion of sulphadimidine in sheep during summer and winter.Veterinary Record,112, 379–381
Nielsen, P. 1973. Metabolism of sulphonamides in goats.Acta Veterinaria Scandinavica.14, 647–649
Nouws, J. F. M., Vree, T. B., Baakman, M., Driessens, F., Bruekink, H. J. & Mevius, D. 1986. Age and dosage dependency in the plasma distribution and the renal clearance of sulfamethazine and its N4-acetyl and hydroxy metabolites in calves and cows.American Journal of Veterinary Research,47, 642–649
VanGogh, H. 1980. Pharmacokinetics of nine sulphonamides in goats.Journal of Veterinary Pharmacology & Therapeutics,3, 69–81
VanGogh, H., VanDeurzen, E. J. M., VanDuin, C. T. M. & VanMiert, A.S.J.P.A.M., 1984. Effect of staphylococcal enterotoxin B-induced diarrhoea on the pharmacokinetics of sulphadimidine in goats.Journal of Veterinary Pharmacology & Therapeutics,7, 303–305
Vree, T. B., Hekster, Y. A. & Tijhuis, M. W. 1985. Pharmacokinetics of sulfonamides revisited.Antibiotic Chemotherapy,34, 5–64
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Abdullah, A.S., Baggot, J.D. The effect of food deprivation on the rate of sulfamethazine elimination in goats. Vet Res Commun 12, 441–446 (1988). https://doi.org/10.1007/BF01075472
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01075472