Abstract
Two examples are given to show how Metzler's nonlinear regression program can be used to estimate parameters in a model with multiple dosing. The model of one example is a set of equations involving sums of exponentials, whereas the other model is a set of differential equations reflecting first order absorption and Michaelis-Menten excretion. In both cases no data were given in one of the dosing intervals.
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References
J. R. Howell. Mathematical formulation for nonuniform multiple dosing.J. Pharm. Sci. 64:464–466 (1975).
C. M. Metzler, G. L. Elfring, and A. J. McEwen.A User's Manual for NONLIN and Associated Programs, Upjohn Co., Kalamazoo, Mich., April 20, 1974.
Y. Bard.Nonlinear Parameter Estimation, Academic Press, New York (1974), Chap. VI.
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Howell, J.R. Nonlinear regression on multiple-dose data. Journal of Pharmacokinetics and Biopharmaceutics 7, 675–679 (1979). https://doi.org/10.1007/BF01061214
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DOI: https://doi.org/10.1007/BF01061214