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Pharmacokinetic approach for reconstruction of predetermined plasma insulin profiles by continuous subcutaneous insulin infusion in depancreatized dogs

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Abstract

A preprogrammable insulin delivery system which can provide the flexibility of varying plasma insulin concentration in a physiological manner has been developed. This system involves a program of continuous subcutaneous infusion of insulin at variable rates to reproduce arbitrarily selected plasma insulin concentration-time profiles. The desired insulin infusion rate profile was calculated from the desired insulin pattern using pharmacokinetic parameters experimentally determined by measurement of immunoreactive plasma insulin following a subcutaneous bolus dose to depancreatized dogs.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, Tokyo College of Pharmacy, 1432-1 Horinouchi, Hachioji, 192-03, Tokyo, Japan

    Hiroki Hirayama & Yasuji Kasuya

  2. Department of Endocrinology and Metabolism, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, 107, Tokyo, Japan

    Tetsuro Kobayashi & Tokuji Itoh

  3. Technical R and D Division, Terumo Corporation, 44-1 2-chome Hatagaya, Shibuya-ku, 151, Tokyo, Japan

    Akira Yagishita, Takeo Katakura & Keinosuke Isono

Authors
  1. Hiroki Hirayama
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  2. Yasuji Kasuya
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  3. Tetsuro Kobayashi
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  4. Tokuji Itoh
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  5. Akira Yagishita
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  6. Takeo Katakura
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  7. Keinosuke Isono
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Hirayama, H., Kasuya, Y., Kobayashi, T. et al. Pharmacokinetic approach for reconstruction of predetermined plasma insulin profiles by continuous subcutaneous insulin infusion in depancreatized dogs. Journal of Pharmacokinetics and Biopharmaceutics 11, 595–609 (1983). https://doi.org/10.1007/BF01059059

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  • DOI: https://doi.org/10.1007/BF01059059

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