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Genetic control of developmental patterns of cerebral enzyme activities: Further differences between C3H and ICR strains of mice

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Abstract

We have investigated developmental changes in activity for five enzymes associated with different cerebral metabolic systems in two separate strains of mice. The enzymes studied were acid β-galactosidase, arylsulfatase A, cerebroside β-galactosidase, cerebroside sulfotransferase, and glutamate decarboxylase. The two strains of mice were C3H/SWV and ICR/SWV. We confirm the experiments of Meisler, Paigen, and colleagues showing higher acid β-galactosidase activity throughout development in C3H mice. In addition we have demonstrated higher arylsulfatase A activity throughout development in C3H mice. The shape of the developmental curve for arylsulfatase A activity in brain in the two strains was similar. There were no differences in developmental changes of activity between the two strains for the other three enzymes studied.

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Authors and Affiliations

  1. Division of Neurology, University of Washington School of Medicine and Seattle Veterans Administration Medical Center, Seattle, USA

    T. D. Bird, D. F. Farrell & S. Stranahan

  2. The Child Development and Mental Retardation Center, University of Washington School of Medicine and Seattle Veterans Administration Medical Center, Seattle, USA

    T. D. Bird, D. F. Farrell & S. Stranahan

Authors
  1. T. D. Bird
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  2. D. F. Farrell
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  3. S. Stranahan
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Bird, T.D., Farrell, D.F. & Stranahan, S. Genetic control of developmental patterns of cerebral enzyme activities: Further differences between C3H and ICR strains of mice. Neurochem Res 6, 863–871 (1981). https://doi.org/10.1007/BF00965044

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  • DOI: https://doi.org/10.1007/BF00965044

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