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Iodine-123-labelled fatty acids for myocardial single-photon emission tomography: current status and future perspectives

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Abstract

Renewed interest in the clinical use of iodine-123-labelled fatty acids is currently primarily focused on the use of iodine-123-labelled 15-(p-iodophenyl)pentadecanoic acid (IPPA) and “modified” fatty acid analogues such as 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) which show delayed myocardial clearance, thus permitting single-photon emission tomographic imaging. Interest in the use of BMIPP and similar agents results from the differences which have often been observed in various types of heart disease between regional myocardial uptake patterns of [123I]BMIPP and flow tracer distribution. Although the physiological basis is not completely understood, differences between regional fatty acid and flow tracer distribution may reflect alterations in important parameters of metabolism which can be useful for patient management or therapy planning. These tracers may also represent unique metabolic probes for correlation of energy substrate metabolism with regional myocardial viability. The two agents currently most widely used clinically are123I-labelled IPPA and BMIPP. While [123I]IPPA is commercially available as a radiopharmaceutical in Europe (Cygne) and Canada (Nordion), multicenter trials are in progress in the United States as a prelude to approval for broad use. [123I]BMIPP was recently introduced as Cardiodine for commercial distribution in Japan (Nihon Medi-Physics, Inc.). [123I]BMIPP is also being used in clinical studies on an institutional approval basis at several institutions in Europe and the United States. In this review, the development of a variety of radioiodinated fatty acids is discussed. The results of clinical trials with [123I]IPPA and [123I]BMIPP are discussed in detail, as are the future prospects for fatty acid imaging.

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References

  1. Visser FC, ed. First Workshop on Radiolabelled Free Fatty Acids, Free University Hospital, Amsterdam, The Netherlands, July 1984.Eur Heart J 1985;6: 1–106.

    Google Scholar 

  2. Visser FC, ed. Second Workshop on Radiolabelled Free Fatty Acids, Free University Hospital, Amsterdam, The Netherlands, November 1987.NucCompact/Eur-Am Commun Nucl Med 1990;21: 201–266.

    Google Scholar 

  3. Yonekura Y, ed. Third International Workshop on Radioiodinated Free Fatty Acids, Japan, 1993.Ann Nucl Med 1993;7: SII-1–SII-116.

  4. van der Wall EE, ed.Noninvasive imaging of cardiac metabolism. Amsterdam: Martinus Nijhoff, 1987.

    Google Scholar 

  5. Evans JR, Gunton RW, Baker RG, Beanlands DS, Spears JC. Use of radioiodinated fatty acids for photoscans of the heart.Circ Res 1965;16: 1–10.

    PubMed  Google Scholar 

  6. Mach RH, Kung HF, Jungwiwattanaporn P, Guo Y-Z. Synthesis and biodistribution of a new class of Tc-99m-labelled fatty acid analogues for myocardial imaging.Nucl Med Biol 1991;18: 215–226.

    Google Scholar 

  7. Poe ND, Robinson GD, Graham S, MacDonald NS. Experimental basis for myocardial imaging with123I-labelled hexadecanoic acid.J Nucl Med 1976;17: 1077–1082.

    PubMed  Google Scholar 

  8. Poe ND, Robinson DG Jr, Zielinski FW, Cabeen WR Jr, Smith JW, Gomes AS. Myocardial imaging with123I-heptadecanoic acid.Radiology 1977;124: 419–424.

    PubMed  Google Scholar 

  9. Freundlich C, Hoeck A, Vyska K, Feinendegen LE, Machulla HJ, Stoecklin G. Myocardial imaging and metabolic studies with [17-123I]iodoheptadecanoic acid.J Nucl Med 1980;21: 1043–1050.

    PubMed  Google Scholar 

  10. Fridrich L, Gassner A, Sommer G, Kneussl M, Kassal H, Klicpera M, Salomonowitz E. Dynamic123I-HDA myocardial scintigraphy after aortocoronary bypass grafting.Eur J Nucl Med 1986; 12: S24–826.

    PubMed  Google Scholar 

  11. Visser FC, van Eenige MJ, Westera G, den Hollander W, Duwel CMB, van der Wall EE, Heidendal GAK, Roos JP. Metabolic fate of radioiodinated heptadecanoic acid in the normal canine heart.Circulation 1985;72: 565–571.

    PubMed  Google Scholar 

  12. Duwel CMB, Visser FC, van Eenige MJ, et al. Metabolic testing of the heart with lactate and glucose during labelled FFA scintigraphy.Acta Cardiol 1988;43: 111–120.

    PubMed  Google Scholar 

  13. Duwel CMB, Visser FC, van Eenige MJ, van der Lugt HAM, Roos JP. The influence of glucose on the myocardial time-activity curve during 17-iodo-123 heptadecanoic acid scintigraphy.Nucl Med Comm 1987;8: 207–215.

    Google Scholar 

  14. van Eenige MJ, Visser FC, Duwel CMB, Karreman AJP, van Lingen A, Roos JP. Comparison of 17-iodine-131 heptadecanoic acid kinetics from externally measured time-activity curves and from serial myocardial biopsies in an open-chest canine model.J Nucl Med 1988;29: 1934–1942.

    PubMed  Google Scholar 

  15. Sloof GW, Visser FC, Teerlink T, et al. Incorporation of radioiodinated fatty acids into cardiac phospholipids of normoxic myocardium.Mol Cell Biochem 1993;116: 79–87.

    Google Scholar 

  16. Reske SN, Auner R, Winkler C. Kinetics of 17-(123I)iodoheptadecanoic acid in myocardium of rats.J Radioanalyt Chem 1983,79: 355–361.

    Google Scholar 

  17. Railton R, Rogers JC, Small DR, Harrower ADB. Myocardial scintigraphy with I-123 heptadecanoic acid as a test for coronary heart disease.Eur J Nucl Med 1987;13: 63–66.

    PubMed  Google Scholar 

  18. Dudczak R, Kletter K, Frichauf H, Losert U, Angelberger P, Schmoliner R. The use of I-123-labelled heptadecanoic acid (HDA) as a metabolic tracer: preliminary report.Eur J Nucl Med 1984;9: 81–85.

    PubMed  Google Scholar 

  19. Machulla HJ, Stoecklin G, Kupfernagel C, Freundlieb C, Höck A, Vyska K, Feinendegen LE. Comparative evaluation of fatty acids labelled with C-11, Cl-34m, Br-77 and I-123 for metabolic studies of the myocardium: concise communication.J Nucl Med 1978;19: 298–302.

    PubMed  Google Scholar 

  20. Machulla HJ, Marsmann M, Dutschka KP. Biochemical concept and synthesis of a radioiodinated phenylfatty acid for in vivo metabolic studies of the myocardium.Eur J Nucl Med 1980;5: 171–173.

    PubMed  Google Scholar 

  21. Knoop F. Der Abbau aromatischer Fettsäuren im Tierkörper.Beitr z them Physiol Path 1905;6: 150–156.

    Google Scholar 

  22. Machulla HJ, Marsmann M, Dutschka KP. Radiopharmaceuticals. I. Synthesis of radioiodinated phenylfatty acids for studying myocardial metabolism.J Radioanalyt Chem 1980; 56:253–261.

    Google Scholar 

  23. Reske SN, Sauer W, Machulla HJ, Winkler C. 15-(p-[I-123]phenyl)pentadecanoic acid as tracer of lipid metabolism. Comparison with 1-C-14 palmitic acid in murine tissues.J Nucl Med 1984;25: 1335–1342.

    PubMed  Google Scholar 

  24. Schön HR, Schelbert HR, Robinson G, Najafi A, Huang SC, Hansen H, Barrio J, Kuhl DE, Phelps ME. C-11 labelled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography.Am Heart J 1982;103: 532–547.

    PubMed  Google Scholar 

  25. Kropp J, Ambrose KR, Knapp FF Jr, Nissen HP, Biersack HJ. Incorporation of radioiodinated IPPA and BMIPP fatty acid analogues into complex lipids from isolated rat hearts.Nucl Med Biol 1992;19: 283–288.

    Google Scholar 

  26. Caldwell JH, Martin GV, Link JM, Krohn KA, Bassingthwaighte JB. Iodophenylpentadecanoic acid-myocardial blood flow relationship during maximal exercise with coronary occlusion.J Nucl Med 1990;31: 99–105.

    PubMed  Google Scholar 

  27. Kennedy PL, Corbett JR, Kulkarni PV, Wolfe CL, Jansen DE, Hansen CL, Buja LM, Parkey RW, Willerson JT. Iodine 123-phenylpentadecanoic acid myocardial scintigraphy: usefulness in the identification of myocardial ischemia.Circulation 1986;74: 1007–1015.

    PubMed  Google Scholar 

  28. Hansen CL, Corbett JR, Pippin JJ, Jansen DE, Kulkarni PV, Ugolini V, Henderson E, Akers M, Buja LM, Parkey RW, Willerson JT. Iodine-123 phenylpentadecanoic acid and single photon emission computed tomography in identifying left ventricular regional metabolic abnormalities in patients with coronary heart disease: comparison with thallium-201 myocardial tomography.J Am Coll Cardiol 1988;12: 78–87.

    PubMed  Google Scholar 

  29. Zimmermann R, Rauch B, Kapp M, Bubeck B, Neumann FJ, Seitz F, Stokstad P, Mall G, Tillmanns H, Kühler W. Myocardial scintigraphy with iodine-123 phenylpentadecanoic acid and thallium-201 in patients with coronary artery disease: a comparative dual-isotope study.Eur J Nucl Med 1992;19: 946–954.

    PubMed  Google Scholar 

  30. Duwel CMB, Visser FC, van Eenige MJ, Westera G, Roos JP. The influence of lactate and dipyridamole on myocardial fatty acid metabolism in man, traced wih123I-17-iodoheptadecanoic acid.NuclMed 1990;29: 8–34.

    Google Scholar 

  31. Duwel CMB, Visser FC, van Eenige MJ, Den Hollander W, Roos JP. The fate of123I-17-iodoheptadecanoic acid during lactate loading: its oxidation is strongly inhibited in favor of its esterification.NuclMed 1990;29: 24–27.

    Google Scholar 

  32. Drake AJ, Haines JR, Noble MIM. Preferential uptake of lactate by the normal myocardium in dogs.Cardiovasc Res 1980;14: 65–72.

    PubMed  Google Scholar 

  33. Spitzer JJ. Effect of lactate infusion on canine myocardial free fatty acid metabolim in vivo.Am J Physiol 1974;226: 213–217.

    PubMed  Google Scholar 

  34. Keul J, Doll E, Steim H, Fleer H, Reindell H. Über den Stoffwechsel des menschlichen Herzens. III. Der oxydative Stoffwechsel des menschlichen Herzens unter verschiedenen Arbeitsbedingungen.Pflügers Arch 1965;282: 43–53.

    Google Scholar 

  35. Keul J, Doll E, Steim H, Homburger H, Krn H, Reindell H. Über den Stoffwechsel des menschlichen Herzens. I. Die Substratversorgung des gesunden menschlichen Herzens in Ruhe, während und nach körperlicher Arbeit.Pflügers Arch 1965;282: 1–27.

    Google Scholar 

  36. Liedtke AJ, Nellis S, Neely JR. Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine.Circ Res 1978;43: 652–661.

    PubMed  Google Scholar 

  37. Kropp J, Fehske W, Krois M, Möller J, von Smekal A, Likungu J, Kirchhoff PG, Lüderitz B, Biersack HJ. Influence of revascularization on myocardial perfusion, metabolism and function.Ann Nucl Med 1993;7: SII–69-SII–78.

    Google Scholar 

  38. Eisenhut M, Lehmann WD, Sütterle A. Metabolism of 15-(4′-[123iodophenyl)pentadecanoic acid [123I]IPPA) in the rat heart: identification of new metabolites by high pressure liquid chromatography and fast atom bombardment-mass spectrometry.Nucl Med Biol 1993;6: 747–754.

    Google Scholar 

  39. Pippin JJ, Jansen DE, Henderson EB, et al. Myocardial fatty acid utilization at various workloads in normal volunteers: iodine-123 phenylpentadecanoic acid and single photon emission computed tomography to investigate myocardial metabolism.Am J Cardiol Imaging 1992;6: 99–108.

    Google Scholar 

  40. Reske SN, Knapp FF Jr, Nitsch J, Kropp J, Reichmann K, Winkler C. Ergebnisse der Fettsäure-SPECT des Myokards bei der koronaren Herzerkrankung.NuclMed 1986;25: 90–98.

    Google Scholar 

  41. Kropp J, Likungu J, Kirchhoff PG, Knapp FF Jr, Reichmann K, Reske SN, Biersack HJ. SPECT-imaging of myocardial oxidative metabolism with (I-123)IPPA in patients with coronary artery disease and aorto-coronary bypass graft surgery.Eur J Nucl Med 1991:18: 467–474.

    PubMed  Google Scholar 

  42. Pippin JJ, Jansen DE, Henderson EB, Hansen C, Ugolini V, Kulkarni PV, Corbett JR. SPECT demonstration of workload and sex-related variabilitiy of myocardial fatty acid utilization in normals.J Nucl Med 1988;29: 841

    Google Scholar 

  43. Reske SN, van der Lohe E, Simon HJ, Büll U. Einfluss von Laktet auf die Oxidation freier Fettsäuren (FFAO) in normalem und ischämischem Myokard.Z Kardiol 1989;78: Suppl 1: 131.

    PubMed  Google Scholar 

  44. Kropp J, Köhler U, Fehske W, Knapp FF Jr, Grünwald F, Biersack HJ. Semiquantitative 15-(p-[I-123]iodophenyl)pentad-ecanoic acid (IPPA)-SPECT in the detection of coronary artery disease.Ann Nucl Med 1993;7: SII–59-SII–67.

    Google Scholar 

  45. Hansen CL, Heo J, Oliner C, van Decker W, Iskandrian AS. Prediction of functional recovery with I-123 phenylpentadecanoic acid after coronary revascularization.J Nucl Med 1994;35 Suppl: 49P.

  46. Heo J, Cave V, Kuhlmeier V, Cassel D, Iskandrian AS. Assessment of myocardial viability by serial tomographic iodophenylpentadecanoic acid imaging: comparison to rest-redistribution thallium imaging.J Nucl Med 1994;35 Suppl: 50P.

  47. Wieler H, Kaiser KP, Frank J, Kuikka JT, Ladwein K, Winkens A. Standardized non-invasive assessment of myocardial free fatty acid kinetics by means of 15-(para-iodo-phenyl)pentadecanoic acid (123I-pPPA)scintigraphy. I. Method.Nucl Med Commun 1990;11: 865–878.

    PubMed  Google Scholar 

  48. Wieler H, Kaiser KP, Kuikka JT, Henkel B, Frank J, Ladwein K. Standardized non-invasive assessment of myocardial free fatty acid kinetics by means of 15-(para-iodophenyl)pentad-ecanoic acid (123I-pPPA)scintigraphy. II. Clinical results.Nucl Med Commun 1992;13: 168–185.

    PubMed  Google Scholar 

  49. Schad N, Daus HJ, Ciavolella M, Maccio A. Noninvasive functional imaging of regional rate of myocardial acids metabolism.Cardiologia 1987;32-N3: 239–247.

    Google Scholar 

  50. Schad N. Dynamic IPPA studies: techniques and applications.Ann Nucl Med 1993;7: SII–57-SII–58.

    Google Scholar 

  51. Davies RA, Ruddy TD, Ballinger JR, Spencer P, Habibi H. Exercise myocardial imaging: comparison between iodine-123-phenylpentadecanoic acid and thallium-201. In: Höfer R, Bergmann H, Sinzinger H, eds. Radioactive isotopes in clinical medicine and research. Stuttgart New York: Schattauer; 1989:611–615.

    Google Scholar 

  52. Kropp J, Jörgens C, Glänzer K, Köhler U, Ruhlmann J, Grünwald F, Hotze A, Bier-sack HJ. Flow and viability of the myocardium detected by isonitriles (RP-30) and IPPA fatty acid in patients with coronary artery disease (CHD).Eur J Nucl Med 1990; 16: 471.

    Google Scholar 

  53. Varetto T, Picciotto G, Baccega M, Campana M, De Filippi PG, Martiny W, De Berardinis A, Casaccia M, Cesana P, Ropolo R. Use of I-123-IPPA in evaluation of patients with coronary artery disease.Eur J Nucl Med 1990;16: 472.

    Google Scholar 

  54. Scopinaro F, Penco M, Pagan M, Banci M, Romano S, Camboni C, Dagianti A, Centi Colella A. 99m-Tc-MIBI and 123-I-iodophenylpentadecanoic acid (IPPA) in the detection of myocardial ischemia in patients with multivascular CAD.Eur J Nucl Med 1990;16: 471

    Google Scholar 

  55. Medolago G, Piti A, Tespili M, Gotti R, Virotta G, Adda FD, Balduzzi A, Mazzoleni D, Caspari A, Bertocchi C. Perfusion (Tc99m-MIBI) and metabolic (I123-IPPA) study in recent myocardial infarction by SPET imaging.Eur J Nucl Med 1990;16: 471.

    Google Scholar 

  56. Vyska K, Machulla HJ, Stremmel W, Faßbender D, Knapp WH, Notohamiprodjo G, Gleichmann U, Meyer H, Knust EJ, Körfer R. Regional myocardial free fatty acid extraction in normal and ischemic myocardium.Circulation 1988;78: 1218–1233.

    PubMed  Google Scholar 

  57. Vyska K, Meyer W, Stremmel W, Notohamiprodjo G, Minami K, Machulla HJ, Gleichmann U, Meyer H, Körfer R. Fatty acid uptake in normal human myocardium.Circ Res 1991;69: 857–870.

    PubMed  Google Scholar 

  58. Fox KAA, Abendschein DR, Ambos HD, Sobel BE, Bergmann SR. Efflux of metabolized and nonmetabolized fatty acid from canine myocardium.Circ Res 1985;57: 232–243.

    PubMed  Google Scholar 

  59. Notohamiprodjo G, Vyska K, Stremmel W. Myocardial fatty acid uptake is a carrier mediated process. Proceedings of the First International Congress of Nuclear Cardiology, Cannes, France 1993: 4409.

  60. Schmitz B, Reske SN, Machulla HJ, Egge H, Winkler C. Cardiac metabolism of 15-(p-iodo-phenyl)-pentadecanoic acid: a gas-liquid chromatographic-mass spectrometry analysis.J Lipid Res 1984;25: 1102–1108.

    PubMed  Google Scholar 

  61. Kropp J, Köhler U, Likungu J, Kirchhoff PG, Biersack HJ. Detection of coronary artery disease with the fatty acid [123I]IPPA as a tracer of oxidative metabolism.Circulation 1992;86 Suppl I: 1–797

    PubMed  Google Scholar 

  62. Ferrari R, Di Lia F, Raddino R, Bigoli C, Curello S, Ceconi C, Albertini A, Visioli O. Factors influencing the metabolic and functional alterations induced by ischemia and reperfusion. In: Ferrari R, Katz AM, Shug A, Visioli O, eds. Myocardial ischemia and lipid metabolism. New York London: Plenum, 1984; 135–157.

    Google Scholar 

  63. Parker JO, Chiong MA, West RO, Case RB. Sequential alteration in myocardial lactate metabolism, S-T segments, and left ventricular function during angina induced by atrial pacing.Circulation 1969;40: 113–131.

    PubMed  Google Scholar 

  64. Kurien VA, Olver MF. A metabolic cause for arrhythmias during acute myocardial hypoxia.Lancet 1970;1: 813–815.

    PubMed  Google Scholar 

  65. Reske SN. Viability as seen with radiolabelled fatty acids — a new approach to a challenging problem.Eur J Nucl Med 1994;21: 279–282.

    PubMed  Google Scholar 

  66. Hansen CL. Preliminary report of an ongoing phase I/II dose range, safety and efficacy study of iodine-123-phenylpentadecanoic acid for the identification of viable myocardium.J Nucl Med 1994;35 Suppl: 38S-42S.

    PubMed  Google Scholar 

  67. Kuikka JT, Mussalo H, Hietakorpi S, Vanninen E, Länsimies E. Evaluation of myocardial viability with technetium-99m hexakis-2-methoxyisobutyl isonitrile and iodine-123 phenylpentadecanoic acid and single photon emission tomography.Eur J Nucl Med 1992;19: 882–889.

    PubMed  Google Scholar 

  68. Murray G, Schad N, Ladd W, Allie D, Zwagg RV, Avet P, Rockett J. Metabolic cardiac imaging in severe coronary disease: assessment of viability with iodine-123-iodophenylpentadecanoic acid and multicrystal gamma camera, and correlation with biopsy.J Nucl Med 1992;33: 1269–1277.

    PubMed  Google Scholar 

  69. Murray GL, Schad N, Magill HL. Dynamic low dose I-123-iodophenylpentadecanoic acid metabolic cardiac imaging: comparison to myocardial biopsy and reinjection SPECT thallium in ischemic cardiomyopathy and cardiac transplantation.Ann Nucl Med 1993;7: SII–79-SII–85.

    Google Scholar 

  70. Kuikka JT, Hartikainen J, Mäntysaari M, Pyörälä K. Detection of hibernating myocardium by combining perfusion with pPPA and MIBG assessment.Ann Nucl Med 1993;7: SII–87-SII–92.

    Google Scholar 

  71. Knapp WH, Vyska K, Machulla HJ, Notohamiprodjo G, Schmidt U, Knust EJ, Gleichmann U. Double-nuclide study of the myocardium using201Tl and123I-labelled fatty acids in non-ischemic myocardial diseases.NuclMed 1988;27: 72–78.

    Google Scholar 

  72. Kropp J, Knapp FF Jr, Biersack HJ. Clinical use of fatty acids. In: Limouris GS, Shukla SK, Biersack HJ, eds. Radionuclides for cardiology. Athens: Mediterra Publishers 1994: 159–204.

    Google Scholar 

  73. Dimauro S, Bonilla E, Zeviani M. Mitochondrial myopathies.Ann Neurol 1985;17: 521–526.

    PubMed  Google Scholar 

  74. Turnbull DM, Sherratt HSA. Mitochondrial myopathies: defects in β-oxidation.Biochem Soc Transact 1985;13: 645–648.

    Google Scholar 

  75. Hiromasa S, Ikeda T, Kubota K, et al. Ventricular tachycardia and sudden death in myotonic dystrophy.Am Heart J 1988;115: 914–915.

    PubMed  Google Scholar 

  76. Schwartzkopff B, Frenzel H, Lösse B, Borggrefe M, Toyka KV, Hammerstein W, Seitz R, Deckert M, Breithardt G. Herzbeteiligung bei progressiver externer Ophthalmoplegie (Kearns-Sayre-Syndrom): elektrophysiologiscbe, hämodynamische und morphologische Befunde.Z Kardiol 1986;75: 161–169.

    PubMed  Google Scholar 

  77. Zierz S, Engel AG. Regulatory properties of a mutant carnitine palmitoyl transferase in human skeletal muscle.Eur J Biochem 1985;149: 207–214.

    PubMed  Google Scholar 

  78. Zierz S. Myopathien mit bekannten Stoffwechselstörungen. In: Jerusalem F, Zierz S, eds.Muskelerkrankungen. Stuttgart New York: Thieme; 1991: 317–345.

    Google Scholar 

  79. Müller-Höcker J, Johannes A, Droste M, Kadenbach B, Pongratz D, Hübner G. Fatal mitochondrial cardiomyopathy in Kearns-Sayre syndrome with deficiency of cytochrome-c-oxidase in cardiac and skeletal muscle.Virchows Arch B Cell Pathol 1986;48: 353–367.

    Google Scholar 

  80. Thies WR, Vyska K, Notohamiprodjo G, Matthies W, Knapp WH, Meyer H. Regional free fatty-extraction rates in hypertrophic and dilated cardiomyopathies in children.Circulation 1988;78 Suppl II: II-494.

    Google Scholar 

  81. Ugolini V, Hansen CL, Kulkarni PV, et al. Abnormal fatty acid metabolism in dilated cardiomyopathy detected by iodine-123 phenylpentadecanoic acid and tomographic imaging.Am J Cardiol 1988;62: 923–928.

    PubMed  Google Scholar 

  82. Schad N. Routine cardiac metabolic imaging.Cardiovasc Imag 1990;2: 5–8.

    Google Scholar 

  83. Kuikka JT, Virtanen KS, Mustonen J, Kairento AL, Unsitupa M. I-123 free fatty acid metabolism in the ischemic myocardium and diabetes.J Nucl Med 1988;29: 842.

    Google Scholar 

  84. Notohamiprodjo G, Minami K, Körfer R. Noninvasive assessment of the myocardial fatty acid transport, in patients with severe aortic stenosis for evaluation of patient prognosis and of timing for surgical treatment. Proceedings of the First International Congress of Nuclear Cardiology, Cannes, France, 1993: 504.

  85. Notohamiprodjo G, Schmidt U, Baller D, Gleichmann U. Noninvasive detection of microcirculation disturbances in hypertensives with and without myocardial hypertrophy. Proceedings of the First International Congress of Nuclear Cardiology, Cannes, France, 1993: 6601.

  86. Chen T, Mertens S, Notohamiprodjo G, Park JW, Heinrich KW. Metabolism of the myocardium during stress in patients with transplanted hearts and with cardiomyopathy. Proceedings of the First International Congress of Nuclear Cardiology, Cannes, France, 1993: 6611.

  87. Pippin JJ, Jansen DE, Henderson EB, Corbett JR, van den Berg E, Schmitz J, Dehmer G, Kulkarni PV, Buja LM, Parkey RW, Willerson JT. Single photon emission computed tomography utilizing I-123 phenylpentadecanoic acid metabolism before and after percutaneous transluminal coronary angioplasty.J Nucl Med 1987;28: 1084.

    Google Scholar 

  88. Lenzhofer R, Dudzak R. Indication of doxorubicin cardiotoxieity by impairment of131I-IPPA utilization.Eur J Nucl Med 1986;12: S32-S33.

    Google Scholar 

  89. Knapp FF Jr. Tellurium and selenium as carbon substitutes. In:Proceedings of the First International Symposium on Radiopharmaceuticals: Structure-Activity Relationships, USA 1980. New York: Grime and Stratton; 1981: 345–391.

    Google Scholar 

  90. Elmaleh DR, Knapp FF Jr, Yasuda T, Coofey JL, Kopiwoda S, Okada RD, Strauss HW. Myocardial imaging with123mTe-9-telluraheptadecanoic acid.J Nucl Med 1981;22: 994–999.

    PubMed  Google Scholar 

  91. Okada RD, Strauss HW, Elmaleh DR, Goodman MM, Knapp FF Jr. Tellurium-labelled fatty acid analogues: relationship of heteroatom position on myocardial kinetics.Eur J Nucl Med 1985;11: 156–161.

    PubMed  Google Scholar 

  92. Knapp FF Jr, Ambrose KR, Callahan AP, Ferren LA, Girgsby RA, Irgolic KJ. Effects of chain length and Te-position on the myocardial uptake of Te-123m-labelled fatty acids.J Nucl Med 1981;22: 988–993.

    PubMed  Google Scholar 

  93. Goodman MM, Knapp FF Jr. Synthesis of 15-(p-iodophenyl)-6-tellurapentadecanoic acid: a new myocardial imaging agent.J Med Chem 1982;7: 3004–3006.

    Google Scholar 

  94. Goodman MM, Knapp FF Jr, Callahan AP, Ferren LA. Radioiodinated 15-(p-iodophenyl)-6-tellurapentadecanoic acid: a new myocardial imaging agent exhibiting prolonged myocardial retention.J Nucl Med 1982;23: 904–908.

    PubMed  Google Scholar 

  95. Bianco JA, Alpert JS, Pape LA, Zheng M, Hnatowich D, Goodman MM, Knapp FF Jr. Accumulation of radioiodinated 15-(p-iodophenyl)-6-tellurapentadecanoic acid in necrotic and ischemic myocardium during acute coronary occlusion and reperfusion.J Am Coll Cardiol 1984;4: 80–87.

    PubMed  Google Scholar 

  96. Knapp FF Jr, Kabalka GW, Goodman MM, Sastry KAR, Calahan AP, Ferren LA. New myocardial imaging agents: stabilization of radioiodine as a terminal vinyl iodide moiety on tellurium fatty acids.J Med Chem 1983;26: 1535–1537.

    PubMed  Google Scholar 

  97. Knapp FF Jr, Kabalka GW, Goodman MM, Sastry KAR, Callahan AP, Ferren LA. New myocardial imaging agents: Stabilization of radioiodine as a terminal vinyl iodide moiety on tellurium fatty acids.J Med Chem 1983;26: 1293–1300.

    PubMed  Google Scholar 

  98. Knapp FF Jr, Srivastava PC, Callahan AP, Cunningham EB, Kabalka GW, Sastry KAR. The effect of tellurium position on the myocardial specificity of radioiodinated 18-iodo-17-octadecanoic acid analogues.J Med Chem 1984;27: 57–62.

    PubMed  Google Scholar 

  99. Knapp FF Jr, Goodman MM, Elmaleh DR, Okada RD, Strauss HW. The development of radioiodinated fatty acids for applications in nuclear cardiology. In:Proceedings of the International Symposium on the Developing Role of Short-Lived Radionuclides in Nuclear Medicine Practice. U.S. Department of Energy, 1982, Office of Scientific and Technical Information, Symposium Series 56 (CONF 850623) 1985: 289–311.

  100. Grossman K, Kaiser KP, Geuting B, Machulla HJ, Feinendegen LE.Ortho-Iodo-phenylpentadecanoic acid (OPPA) - its metabolic acceptance without metabolism.Proceedings of the European Congress on Nuclear Medicine, Milan, Italy, 1988. Stuttgart New York: Schattauer; 1989: 691–694.

    Google Scholar 

  101. Antar MA, Spohr G, Herzog HH, Kaiser KP, Notohamiprofjo G, Vester E, Shreeve WW, Feinendegen LE. 15-(ortho-1231-phenyl)-pentadecanoic acid, a new myocardial imaging agent for clinical use.Nucl Med Commun 1986;7:683–696.

    PubMed  Google Scholar 

  102. Henrich MM, Vester E, von der Lohe E, Herzog H, Simon H, Kuikka JT, Feinendegen LE. The comparison of 2-18F-deoxyglucose and 15-(ortho-1231-phenyl)-pentadecanoic acid uptake in persisting defects on thallium-201 tomography in myocardial infarction. J Nucl Med 1991;32: 1353–1357.

    PubMed  Google Scholar 

  103. Geuting B, Kaiser KP, Grossman K, Vester E, Loess B, Machulla HJ, Feinendegen LE. Metabolic behavior of the ortho- and para-isomers of 15-(123I-phenyl)-2-14C-pentad-ecanoic acid (oPPA,pPPA) in human myocardium after intravenous administration.Proceedings of the European Congress on Nuclear Medicine, Milan, Italy, 1988. Stuttgart New York: Schattauer; 1989: 160–163.

    Google Scholar 

  104. Mathecourt J, Fagret D, Cinotti L, Andre-Fouet X, Wolf JE, Beaune J, Le Bars D, Rocca C, Comet M. What is more accurate for the assessment of myocardial viability after myo cardial infarction? 201-T1 and fatty acids SPECT studies were compared with FDG-PET in 15 pts [abstract].Circulation 1992;86 Suppl 1:1–108.

    PubMed  Google Scholar 

  105. Eisenhut M, Liefhold J. Radioiodinated p-phenylene bridged fatty acids as new myocardial imaging agents: syntheses and biodistribution in rats.Appl Radiat Isot 1988;39: 639–649.

    Google Scholar 

  106. Zehelein J, Zimmermann R, Bubeck B, Eisenhut M, Kübler W, Georgi P. SPECT I-123 PHIPA imaging in patients with chronic coronary artery disease: a comparative study with thallium-201.Eur J Nucl Med 1994;21: 811.

    Google Scholar 

  107. Jonas M, Brandau W, Vollet B, Gildehaus FJ, Fahrenkamp A, Weyand M, Puskas C, Scheld HH, Böcker W, Schober O.123I-PHIPA 3-10: a SPET tracer for assessment myocardial viability [abstract].Eur J Nucl Med 1994;21: 736.

    Google Scholar 

  108. Chouraqui, Maddahi J, Henkin R, Karesh SM, Galie E, Berman DS. Comparison of myocardial imaging with iodine123-iodophenyl-9-methyl pentadecanoic acid and thallium 201-chloride for assessment of patients with exercise-induced myocardial ischemia.J Nucl Med 1991;32: 447–452.

    PubMed  Google Scholar 

  109. Goodman MM, Kirsch G, Knapp FF Jr. Synthesis and evaluation of radioiodinated terminalp-iodophenyl-substituted α-β-methyl-branched fatty acids.J Nucl Med 1984;27: 390–397.

    Google Scholar 

  110. Goodman MM, Knapp FF Jr. New myocardial imaging agents: synthesis of 15-(p-iodophenyl)-3-R,S-methylpenta-decanoic acid by decomposition of a piperidinyl triazene precurso.J Org Chem 1984;49:2322–2325.

    Google Scholar 

  111. Knapp FF Jr, Ambrose KR, Goodman MM. New radioiodinated methyl-branched fatty acids for cardiac imaging.Eur J Nucl Med 1986;12: S539-S544.

    Google Scholar 

  112. Reske SN, Knapp FF Jr, Winkler C. Metabolic imaging of the myocardium with radioiodinated aromatic free fatty acid analogues. I. Experimental basis.J Physiol Imaging 1986;1: 214–219.

    Google Scholar 

  113. Goodman MM, Neff K, Ambrose KR, et al. Effect of 3methyl-branching on the myocardial retention of radioiodinated 19-iodo-18-nonadecanoic acid analogues.Nucl Med Biol 1989;16:813–819.

    Google Scholar 

  114. Goodman MM, Callahan AP, Knapp FF Jr. Design, synthesis and evaluation of ω-iodovinyl- and ω-iodoalkyl-substituted methyl-branched fatty acids.J Med Chem 1985;28: 807–814.

    PubMed  Google Scholar 

  115. Knapp FF Jr, Goodman MM. The design and biological properties of iodine-123-labelled β-methyl-branched fatty acids. In: Proceedings of the workshop on radio-labelled free fatty acids, Netherlands 1984.Eur Heart J 1985;6: 71–84.

    Google Scholar 

  116. Knapp FF Jr, Goodman MM, Ambrose KR, Som P, Brill AB, Yamamoto K, Kubota K, Yonekura Y, Dudczak R, Angelberger P, Schmoliner R. The development of radioiodi nated 3-methyl-branched fatty acids for evaluation of myocardial disease by single photon tomography. In: van der Wall EE, ed.Noninvasive measurement of cardiac metabolism. Amsterdam: Martinus Nijhoff: 1987: 159–202.

    Google Scholar 

  117. Ambrose KR, Rice DE, Goodman MM, Knapp FF Jr. Effect of 3-methyl-branching on the metabolism in rat hearts of radioiodinated iodovinyl long-chain fatty acids.Eur J Nucl Med 1987;13: 374–379.

    PubMed  Google Scholar 

  118. Knapp FF Jr, Goodman MM, Callahan AP, Kirsch G. Radioiodinated 15-(p-iodophenyl)-3,3-dimethylpentadecanoic acid: a useful new agent to evaluate myocardial fatty acid uptake. J Nucl Med 1986;27: 521–531.

    PubMed  Google Scholar 

  119. Livni E, Elmaleh DR, Barlai-Kovach MM, Goodman MM, Knapp FF Jr, Strauss HW. Radioiodinated beta-methyl phenyl fatty acids as potential tracers for myocardial imaging and metabolism. In: Proceedings of the workshop on radio-labelled free fatty acids, Academic Hospital, Free University, Holland, July 6, 1984.Eur Heart J 1985;6: 85–90.

  120. Strauss HW, Livni E, Brill B, Knapp FF Jr, Barlai-Kovach M, Keiss MC, Elmaleh DR. In vivo studies of branched-chain fatty acids. In: Heiss HW, ed.Regional myocardial metabolism by positron tomography. Advances in Clinical Pharmacology Series, vol Ill. Foundation for Advances in Clinical Medicine, Mahwah, New Jersey, USA. 1987: 102–105.

  121. Fagret D, Bontemps L, Apparu M, et al. Kinetics of iodomethylated hexadecanoic acid metabolism in the rat myocardium: influence of the number and position of methyl radicals.Int J Nucl Med Biol 1985;12: 363–367.

    PubMed  Google Scholar 

  122. Demaison L, Dubois F, Apparu M, et al. Myocardial metabolism of radioiodinated methyl-branched fatty acids. J Nucl Med 1988;29: 1230–1236.

    PubMed  Google Scholar 

  123. Fagret D, Wolf J-E, Pilichowski, et al. Iodomethylated fatty acid metabolism in mice and dogs.Eur J Nucl Med 1988;14: 624–627.

    PubMed  Google Scholar 

  124. Thomas G, Pepin D, Loriette C, et al. Metabolism of methyl-branched iodo palmitic acids in cultured hepatocytes.Eur J Nucl Med 1989;15: 367–372.

    PubMed  Google Scholar 

  125. Ambrose KR, Owen BA, Goodman MM, Knapp FF Jr. Evaluation of the metabolism in rat hearts of two new radioiodinated 3-methyl-branched fatty acid myocardial imaging agents.Eur J Nucl Med 1987;12: 486–491.

    PubMed  Google Scholar 

  126. Ambrose KR, Owen BA, Callahan, AP, Goodman MM, Knapp FF Jr. Effects of fasting on the myocardial subcellular distribution and lipid distribution of terminal p-iodophe nyl-substituted fatty acids in rat hearts.Nucl Med Biol 1988;5: 695–700.

    Google Scholar 

  127. Knapp FF Jr, Kohlen S, Kolkmeier J, Reske SN, Cunningham EB, Rice DE, Callahn AP, Ambrose KR. Formation of catabolites from methyl-branched fatty acids by isolated Langendorff perfused rat heart system. In:Proceedings, European Nuclear Medicine Congress, Hungary 1987. Stuttgart New York: Schattauer; 1988: 726–730.

    Google Scholar 

  128. Knapp FF Jr, Goodman MM, Reske SN, Ambrose KR, Kirsch G. Radioiodinated methyl-branched fatty acids — evaluation of catabolites formed in vivo.NucCompact/Eur-Am Commun Nucl Med 1990;21: 229–231.

    Google Scholar 

  129. Knapp FF Jr, Reske SN, Ambrose KR, Kohlen S, Kolkmeier J, Goodman MM, Cunningham EB. Formation of polar catabolites from radioiodinated l5-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) by isolated Langendorff rat hearts.NucCompact/Eur-Am Commun Nucl Med 1990;21: 133–139.

    Google Scholar 

  130. Kropp J, Knapp FF Jr, Ambrose KR, Visser F, Biersack HJ, Rogers CJ. Release of an unexpected myocardial metabolite of radioiodinated 15-(p-iodophenyl)-3-R,S-methylpenta decanoic acid (BMIPP) from isolated rat hearts and canine hearts in vivo. J Nucl Med 1990;31: 896.

    Google Scholar 

  131. Ambrose KR, Kropp J; Lambert CR, Biersack HJ, Knapp FF Jr. Back diffusion (BD) and release of metabolites (“X”) contribute to washout of radioiodinated BMIPP from isolated rat hearts (RH).Eur J Nucl Med 1991;18: 671.

    Google Scholar 

  132. Humbert T, Luu-Duc C, Comet M, et al. Evaluation of cellular viability by quantitative autoradiographic study of myocardial uptake of a fatty acid analogue in isoproterenol-in duced focal rat heart necrosis.Eur J Nucl Med 1991;18: 870–878.

    PubMed  Google Scholar 

  133. Humbert T, Keriel C, Batlle D, et al. Influence of the presence of a methyl group on the myocardial metabolism of 15(para-iodophenyl)-3-methyl pentadecanoic acid (IMPPA).Nucl Med Biol 1990; 17: 745–749.

    Google Scholar 

  134. Yonekura Y, Brill AB, Som P, Yamamoto K, Srivastava SC, Iwai J, Elmaleh DR, Livni E, Strauss HW, Goodman MM, Knapp FF Jr. Quantitative autoradiographic measurement of regional myocardial substrate utilization in hypertensive rats.Science 1985;227: 1494–1496.

    PubMed  Google Scholar 

  135. Yamamoto K, Som P, Brill AB, Yonekura Y, Srivastava SC, Meinken GE, Iwai J, Goodman MM, Knapp FF Jr. Dual tracer autoradiographic study of β-methyl-(1-14C) heptad ecanoic acid and 15-p-(131I)-iodophenyl-β-methylpenta-decanoic acid in normotensive and hypertensive rats.J Nucl Med 1986;27: 1178–1183.

    PubMed  Google Scholar 

  136. Kurata C, Kobayashi A, Yamazaki, et al. Dual tracer autoradiographic study with thallium-201 and radioiodinated fatty acid in cardiomyopathic hamsters.J Nucl Med 1989;30: 80–87.

    PubMed  Google Scholar 

  137. Kurata C, Hayashi H, Kobayashi A, et al. Dual tracer autoradiographic study of radioiodinated fatty acid and thallium201 in cardiomyopathic hamsters.Circulation 1987;76: 509.

    Google Scholar 

  138. Som P, Oster ZH, Goodman MM, Knapp FF Jr. Microimaging studies with myocardial substrate utilization and perfusion in two models of non-coronary heart disease.NucCompact/Eur-Am Commun Nucl Med 1990;21: 259–262.

    Google Scholar 

  139. Som P, Wang G-J, Oster ZH, Knapp FF Jr, Yonekura Y, Fujibayashi Y, Yamamoto K, Kubota K. Myocardial uptake of cocaine and effects of cocaine on myocardial substrate utili zation and perfusion in hypertensive rats.Ann Nucl Med 1993;7: 19–26.

    Google Scholar 

  140. Wang G-J, Som P, Oster, ZH, Volkow ND, Knapp FF Jr, Sacker DF. Quantitative autoradiographic measurement of cocaine-induced regional myocardial metabolic changes in hypertensive rats.Nucl Med Biol 1994;21: 245–250.

    PubMed  Google Scholar 

  141. Reske SN, Knapp FF Jr, Nitsch J. 3,3-Dimethyl-(p-1-123-phenyl)pentadecanoic acid (DMIPP) uptake is excess to rMBF in reperfused myocardium.J Nucl Med 1989;30: 797.

    Google Scholar 

  142. Reske SN, Knapp FF Jr, Nitsch J, Kohlen S, Kolkmeier J. 3,3-Dimethyl-(p-I-123-pbenyl)pentadecanoic acid (DMIPP) uptake is excess to rMBF in reperfused myocardium.Eur J Nucl Med 1989;15: 398.

    Google Scholar 

  143. Sloof GW, Visser FC, van Eenige MJ, Comans EFI, Teerlink T, Herscheid K, van der Vusse GJ, Knapp FF Jr. Comparison of uptake, oxidation and lipid distribution of 17-iod oheptadecanoic acid (IHA), 15-(p-iodophenyl)pentad-ecanoic acid (IPPA) and 15-(p-iodophenyl)-3,3-dimethylpentadecanoic acid (DMIPPA) in normal canine myocardium.J Nucl Med 1993;34: 649–657.

    PubMed  Google Scholar 

  144. Bianco JA, Elmaleh DR, Leppo JA, et al. Effect of glucose and insulin infusion on the myocardial extraction of a radioiodinated methyl-substituted fatty acid.Eur J Nucl Med 1986;12: 120–124.

    PubMed  Google Scholar 

  145. Kariento AL, Livni E, Mattila S, et al. Comparative evaluation of [123I] 14-p-iodophenyl-beta-methylpenadecanoic acid and thallium-201 in the detection of infarcted areas in the dog heart using SPET.Nucl Med Biol 1988;15: 333–338.

    Google Scholar 

  146. Dudczak R, Schmoliner R, Angelberger P, Knapp FF Jr, Goodman MM. Structurally modified fatty acids: clinical potential as tracers of metabolism.Eur J Nucl Med 1986;12: 45–48.

    Google Scholar 

  147. Kropp J, Jorgens M, Glanzer K, Knapp FF Jr, Biersack HJ. Evaluation of ischemia and myocardial viability in patients with CAD with the fatty acid l5-(p-[I-123]iodophenyl)-3-R,S-methylpentadecanoic acid. First International Congress of Nuclear Cardiology, France 1993.

  148. Kropp J, Köhler U, Knapp Jr. FF, Biersack JH. 15-(p-[I-123]iodophenyl)-3-R,S-methylpentadecanoic acid to evaluate ischemia in patients with coronary artery disease.Eur J Nucl Med 1991;18: 650.

    Google Scholar 

  149. Yamamichi Y Shirakami Y, Morishita K, Kurami M, Kusuoka H, Nishimura T. Intramyocardial metabolism of β-methyl-p-iodophenylpentadecanoic acid (BMIPP).J Nucl Med 1994;35: 97P.

  150. Kropp J, Knapp FF Jr, Assman T, Ambrose KR, Biersack HJ. Metabolites of IPPA, BMIPP and DMIPP fatty acids in rat hearts. A quantitative HPLC study. In:Nuclear medicine — state of the art in Europe. Proceedings of the European Nuclear Medicine Congress. Stuttgart New York: Schattauer; 1991: 109–111.

    Google Scholar 

  151. Sloof GW Visser FC, Teerlink T, Comans EFI, van Einige MJ, van der Vusse GJ, Knapp FF Jr. Incorporation of radio-iodinated fatty acids into cardiac phospholipids of normoxic canine myocardium. In: Proceedings of Third International Symposium on Lipid Metabolism in the Normoxic and Ischemic Heart, Netherlands 1991.J Mol Cell Biochem 1992;116: 79–87.

    Google Scholar 

  152. van der Wall EE, Barrett E, Strauss HW et al. Altered uptake and kinetics of radioiodinated 15-(p-[I-125]iodophe-nyl)-3-methylpentadecanoic acid in diabetic myocardium.Circulation 1985;72 Suppl 111: 111–424.

    Google Scholar 

  153. Kiess MC, Barlai-Kovach M, Elmaleh D, et al. Discordance between blood flow and fatty acid uptake in the myocardium following lactate infusion. J Nucl Med 1984;25: 79.

    Google Scholar 

  154. Kubota K, Takahashi T, Fujiwara T, et al. Possibility for tumor detection with fatty acid analogues.Nucl Med Biol 1991;18: 191–195.

    Google Scholar 

  155. Ogata M, Kajiyama K, Yamaguchi Y, et al. BMIPP uptake in adriamycin cardiomyopathic rat hearts.J Mol Cell Cardiol 1988;20: 28.

    Google Scholar 

  156. Fujibayashi Y, Yonekura Y, Takemura Y et al. Myocardial accumulation of iodinated beta-methyl-branched fatty acid analogue, iodine- 125-15-(p-iodophenyl)-3-(R,S)-methylpenta-decanoic acid (BMIPP), in relation to ATP concentration.J Nucl Med 1990;31: 1818–1822.

    PubMed  Google Scholar 

  157. Fujibayashi Y, Yonekura Y, Tamaki N, Yamamoto K, Som P, Knapp FF Jr, Konishi J, Yokoyama A. Myocardial accumulation of BMIPP in relation to ATP concentration.Ann Nucl Med 1993;7: 15–18.

    Google Scholar 

  158. Miller DD, Gill JB, Livni E, et al. Fatty acid analogue accumulation: a marker of myocyte viability in ischemic-reperfused myocardium.Circ Res 1988; 63: 681–693.

    PubMed  Google Scholar 

  159. Miller DD, Barlai-Kovach M, Gill JB, et al. Imaging characteristics of a new single-photon myocardial metabolic tracer.Circulation 1986;74: 62.

    Google Scholar 

  160. Miller DD, Gill JB, Barali-Kovach M, et al. Identification of the ischemic border zone in reperfused canine myocardium using iodinated fatty acid analogues.Circulation 1985;72: 1392.

    Google Scholar 

  161. Nishimura T, Sago M, Kihara K, et al. Fatty acid myocardial imaging using123I-β-methyl-iodophenyl pentadecanoic acid (BMIPP): comparison of myocardial perfusion and fatty acid utilization in canine myocardial infarction (occlusion and reperfusion model).Eur J Nucl Med 1989;15: 341–345.

    PubMed  Google Scholar 

  162. Knapp FF Jr, Kropp J, Goodman MM, Franken P, Reske SN, Ambrose KR, Som P, Biersack III, Sloof GW, Visser FC. The development of iodine-123-methyl-branched fatty acids and their applications in nuclear cardiology. Ann Nucl Med 1993;7:1–14.

    PubMed  Google Scholar 

  163. Nishimura T, Uehara T, Shimonagata T, Nagata S, Haze K. Clinical experience of 1231-BMIPP myocardial imaging for myocardial infarction and hypertrophic cardiomyopathy.Ann Nucl Med 1993;7: 35–40.

    Google Scholar 

  164. Takeishi Y, Chiba J, Abe S, et al. Heterogeneous myocardial distribution of iodine-123 15-(p-iodophenyl)-3-R,S-methy1-pentadecanoic avid (BMIPP) in patients with hypertrophic cardiomyopathy. Eur J Nucl Med 1992;19: 775–782.

    PubMed  Google Scholar 

  165. Morita K, Yanagimoto S, Otsuka N, Ono S, Nagai K, Tomomitsu T, Mimura H, Neuzo S, Swayarna T, Fukunaga M. I-123-BMIPP scintigraphy in seven cases with cardiomyopathy.Ann Nucl Med 1993;7: 101–107.

    Google Scholar 

  166. Kurata C, Tawahara K, Okayama K, Wakabayashi Y, Kobayashi A, Yamazaki N, Kaneko M. Myocardial imaging with radioiodinated beta-methyl-branched fatty acid in cardiomyopathy.Ann. Nucl Med 1993;7: 27–34.

    Google Scholar 

  167. Tamaki N, Kawamoto M, Yonekura Y, et al. Regional metabolic abnormality in relation to perfusion and wall motion in patients with myocardial infarction: assessment with emis sion tomography using iodinated branched fatty acid analogue.J Nucl Med 1992;33: 659–667.

    PubMed  Google Scholar 

  168. Tomiguchi S, Oyama Y, Nabeshima M, Nakashima R, Ono M, Kojima A, Hara M, Takahashi M, Motomura K, Yasue H. Quantitative evaluation of BMIPP in patients with ischemic heart disease.Ann Nucl Med 1993;7: 107–112.

    Google Scholar 

  169. Kropp J, Jörgens M, Glaenzer K, Luederitz B, Biersack H-J, Knapp FF Jr. Evaluation of ischemia and myocardial viability in patients with coronary artery disease (CAD) with io dine-123 labelled (15-(p-iodophenyl)-3-R,S-methylpenta-decanoic acid (BMIPP).Ann Nucl Med 1993;7: 93–100.

    Google Scholar 

  170. Franken PR, DeGeeter F, Dedale P, et al. 1231 β-methyl-iodophenylpentadecanoic acid (BMIPP) and99mTcMIBI to identify ischemic but viable myocardium. First International Congress of Nuclear Cardiology, Cannes, France 1993: 25–28.

  171. DeGeeter FF, Franken P, Knapp FF Jr, Boosuyt A. Relationship between blood flow and fatty acid metabolism in subacute myocardial infarction: a study by means of Tc-99m sestamibi and iodine-123-beta-methyl iodophenylpentadecanoic acid.Eur J Nucl Med 1994;21: 283–291.

    PubMed  Google Scholar 

  172. Franken PR, De Geeter F, Dendale P, Demoor D, Block P, Bossuyt A. Abnormal free fatty acid uptake in subacute myocardial infarction after coronary thrombolysis: correla tion with wall motion and inotropic reserve.J Nucl Med 1994;35: 1758–1765.

    PubMed  Google Scholar 

  173. Tamaki N, Kawamoto M, Yonekura Y, Fujibayashi Y, Magata Y, Torizuka T, Tadamura E, Nohara R, Sasayama S, Konishi J. Assessment of fatty acid metabolism using I-123 branched fatty acid: comparison with positron emission tomography.Ann Nucl Med 1993;7: 41–48.

    Google Scholar 

  174. Kawamoto M, Tamaki N, Yonekura Y, Tadamura E, Fujibayashi Y, Magat Y, Nohara R, Sasayama S, Ikekubo K, Kato H, Konishi J. Combined study with 1-123 fatty acid and thallium-201 to assess ischemic myocardium: comparison with thallium redistribution and glucose metabolism.Ann Nucl Med 1994;8: 47–54.

    PubMed  Google Scholar 

  175. Knabb RM, Bergmann SR, Fox KAA, et al. The temporal pattern of recovery of myocardial perfusion and metabolism delineated by positron emission tomography after coronary thrombolysis.J Nucl Med 1987;28: 1563–1570.

    PubMed  Google Scholar 

  176. Stremmel W. Fatty acid uptake by isolated rat heart myocyctes represents a carrier-mediated transport process.J Clin Invest 1988;81: 844–852.

    PubMed  Google Scholar 

  177. Glatz JFC, van der Vusse GJ, Reneman RS. Protective role of fatty acid-binding protein in ischemic and reperfused heart.Circ Res 1991;68: 1490–1491.

    PubMed  Google Scholar 

  178. Morishita S, Suzuki N, Kurami M, Nishimura T. Myocardial intracellular kinetics of branched-chained free fatty acid, I-123 BMIPP.J Nucl Med 1994;35: 97P.

  179. Reske SN, Koischwitz D, Reichmann K, Machulla HJ, Simon H, Knopp R, Winkler C. Cardiac metabolism of 15 (p-I-123 phenyl) pentadecanoic acid after intracoronary tracer application.Eur J Radiol 1984;4: 144–149.

    PubMed  Google Scholar 

  180. Poe ND, Robinson C, MacDonald NS. Myocardial extraction of labelled longchain fatty acid analogs.Proc Soc Exp Biol Med 1975;148: 215–218.

    PubMed  Google Scholar 

  181. Henrich MM, Groβmann K, Metz W, Vogt M, Vester E, Holschbach M, Hamkens W, Notobamiprodjo G, Strauer BE, Feinendegen LE. Beta-oxidation of 1-[14C]-17-[131I]-iodoheptadecanoic acid following intracoronary injection in humans results in similar release of both tracers.Eur J Nucl Med 1993;20: 225–230.

    PubMed  Google Scholar 

  182. Dudzak R. Myokardszintigraphie mit Jod-123-markierten Fettsäuren.Wien Klin Wochenschr 1983; 95 Suppl 143: 1–38.

    Google Scholar 

  183. Okano S, Yoshimura H, Okano K, Itoh O, Kurami M, Ikekubo K, Yonekura Y, Nishimura T, Torizuka K. Metabolite of 15-p-iodophenyl-3-R,S-pentadecanoic acid (1231) in blood and urine. Jpn J Nucl Med 1992;29: 1489–1493.

    Google Scholar 

  184. Torizuka K, Yonekura Y, Nishimura T, Tamaki N, Uehara T, Ikekubo K, Hino M. The phase 1 study of β-methyl-p-(123I)-iodophenyl-pentadecanoic acid (1231-BMIPP).Jpn J Nucl Med 1991; 28: 681–690.

    Google Scholar 

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  1. Nuclear Medicine Group, Health Sciences Research Division, Oak Ridge National Laboratory (ORNL), 37831-6229, Oak Ridge, TN, USA

    F. F. Knapp Jr.

  2. Klinik und Poliklinik für Nuklearmedizin des Universitätsklinikums der Technischen Universität, Fetscher Strasse 74, D-01307, Dresden, Germany

    J. Kropp

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Knapp, F.F., Kropp, J. Iodine-123-labelled fatty acids for myocardial single-photon emission tomography: current status and future perspectives. Eur J Nucl Med 22, 361–381 (1995). https://doi.org/10.1007/BF00941855

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