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Recognition of heterogeneous lymphokine-activated killer (LAK) receptors on Kaposi's sarcoma cells, endothelial cells, and monocytes/macrophages: Evidence of distinct LAK-cell antigen on Kaposi's sarcoma cells—Potential for use of LAK cells for immunotherapy

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Abstract

The purpose of this study was to determine the potential use of lymphokine-activated killer (LAK) cells against Kaposi's sarcoma (KS) cells. We used chromium release cold-target inhibition assay for understanding the expression of heterogeneous LAK-cell antigens (Ags) on KS cells, endothelial cells (ECs), and monocytes/macrophages (Mø) which could allow for the utilization of LAK-cell immunotherapy in KS without side effects. Our data show that (i) all three cell types express the CD18 Ag of LFA-1 or Leu-CAM, (ii) rare KS cells from eyes cannot cold target-inhibit ECs, (iii) KS cells express a distinct LAK-cell Ag, which we have called LAK-KS Ag, and (iv) LAK-KS Ag allows for cold-target inhibition between different KS cells. The identification of LAK-KS Ag and a monoclonal antibody capable of inhibiting lysis of ECs and Mø without obstructing LAK-KS Ag would be important.

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Authors and Affiliations

  1. Norris Cancer Hospital and Research Institute, University of Southern California, 90033, Los Angeles, California

    Mahruf U. Rahman

  2. Department of Medical Oncology, Georgetown University School of Medicine, 3800 Reservoir Road, N.W., 2007, Washington, D.C.

    Amitabha Mazumder

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  1. Mahruf U. Rahman
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  2. Amitabha Mazumder
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Rahman, M.U., Mazumder, A. Recognition of heterogeneous lymphokine-activated killer (LAK) receptors on Kaposi's sarcoma cells, endothelial cells, and monocytes/macrophages: Evidence of distinct LAK-cell antigen on Kaposi's sarcoma cells—Potential for use of LAK cells for immunotherapy. J Clin Immunol 12, 281–288 (1992). https://doi.org/10.1007/BF00918152

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  • DOI: https://doi.org/10.1007/BF00918152

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