Abstract
A 7-year-old boy with end-stage renal disease on long-term peritoneal dialysis is described. The child developed intracranial hypertension and acute glaucoma during therapy with recombinant human growth hormone (rhGH), 18 months after the onset of treatment. Symptoms developed within 1.5 days and required neurosurgical treatment to reduce the intracranial hypertension because of imminent impaction of the cerebellum and brain stem. After ventricular cerebrospinal fluid drainage and cessation of growth hormone, all symptoms of intracranial hypertension and increased intraocular pressure disappeared. To our knowledge this is the first report of intracranial hypertension or hydrocephalusand acute glaucoma during rhGH therapy. Continuous and long-term control of the ophthalmological and neurological status of patients treated with rhGh is indicated.
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References
Chang D, Nagamoto G, Smith WE (1992) Benign intracranial hypertension and chronic renal failure. Cleve Clin J Med 59: 419–422
Malozowski S, Tanner LA, Wysowski D, Fleming GA (1993) Growth hormone, insulin like growth factor I and benign intracranial hypertension. N Engl J Med 329: 665–666
Donaldson J (1981) Pathogenesis of pseudotumor cerebri syndromes. Neurology 31: 877–880
Jain N, Rosner F (1992) Idiopathic intracranial hypertension: report of seven cases. Am J Med 93: 391–395
Griffin J (1992) A review of the literature on benign intracranial hypertension associated with medication. Adverse Drug React Toxicol Rev 11: 41–58
Durcan FJ, Corbett JJ, Wall M (1988) The incidence of pseudotumor cerebri: population studies in Iowa and Louisiana. Arch Neurol 45: 875–877
Guy JR, Day AL, Glase JS (1987) Pseudotumor cerebri in chronic renal failure. Neurology 37 [Suppl 1]: 289
Keech RV, Tongue AC, Scott WE (1989) Complications after surgery for congenital and infantile cataracts. Am J Ophthalmol 108: 136–141
Lessell S (1992) Pediatric pseudotumor cerebri (idiopathic intracranial hypertension). Surv Opththalmol 37: 155–166
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Wingenfeld, P., Schmidt, B., Hoppe, B. et al. Acute glaucoma and intracranial hypertension in a child on long-term peritoneal dialysis treated with growth hormone. Pediatr Nephrol 9, 742–745 (1995). https://doi.org/10.1007/BF00868727
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DOI: https://doi.org/10.1007/BF00868727