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Gastric emptying of two radiolabelled antacids with simultaneous monitoring of gastric pH

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Abstract

The aim of this study was to assess the gastric emptying rate of two antacids using an scintigraphic technique and simultaneous monitoring of gastric pH in 16 healthy male volunteers. Ten ml of Talcid (hydrotalcite 1 g) and Maalox (Mg-Al-hydroxide), with a similar neutralization capacity, were labelled with technetium-99m using a pyrophosphate bridge. Labelled antacids were given on separate days (within 2 weeks), 1 h after a standard meal. Intragastric pH was measured for at least 4 h, using ambulatory pH-metry with a dual-crystant antimony catheter. Continuous monitoring was started 1 h prior to the meal (baseline) and lasted 3 h (post-prandial, post-antacid and final periods). The antacid capacity of labelled and unlabelled antacids was similar. The mean percentages of antacids retained in the stomach fitted a linear model. The mean half-emptying time of Talcid was 63.9±27.9 min, while that of Maalox was 57.3±23.9 min (P=NS). The recordings of gastric pH (mean values of pH for each period) showed a similar profile for both antacids. The mean pH (Maalox vs Talcid) was 1.69 vs 2.07 in the baseline period, 1.95 vs 1.93 in the post-prandial period, 1.79 vs 1.15 in the post-antacid period (P=NS) and 0.4 vs 0.52 in the final period (P<0.05 vs prior periods). In conclusion, the gastric emptying of Talcid and Maalox was similar and pH profiles were parallel and remained unchanged for the two antacids within the first hour of intake. A significant decrease in pH was observed 1 h after intake of the antacids, suggesting a possible rebound effect.

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Authors and Affiliations

  1. Servicio de Patologia Digestiva, Hospital de la Santa Creu i Sant Pau, Av. Antonio M Claret 167, E-08025, Barcelona, Spain

    J. Monés, S. Sainz, P. Clavé & F. Vilardell

  2. Serviccio de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Universitat Autónoma Barcelona, Spain

    I. Carrio, L. Berná & M. Roca

  3. Bayer AG, Germany

    M. Liszkay

Authors
  1. J. Monés
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  2. I. Carrio
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  3. S. Sainz
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  4. L. Berná
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  5. P. Clavé
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  6. M. Liszkay
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  7. M. Roca
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  8. F. Vilardell
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Monés, J., Carrio, I., Sainz, S. et al. Gastric emptying of two radiolabelled antacids with simultaneous monitoring of gastric pH. Eur J Nucl Med 22, 1123–1128 (1995). https://doi.org/10.1007/BF00800593

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  • DOI: https://doi.org/10.1007/BF00800593

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