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The role of the cell surface in the mechanism of the action of antineoplastic drugs (literature survey)

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Conclusions

Thus, from the literature material cited above, it can be seen what an important and frequently deciding role is played by the plasma membrane of the cells in the mechanism of the action of antineoplastic durgs. Part of the published studies have been devoted to methods of penetration of substances into cells and the detection of factors influencing this process, while another part (the majority) treat the problem of the interaction of preparations with the cell surface with attempts to change the nature of this interaction in order to enhance the injurious effect of the preparation on the tumor cell. An analysis of the literature data on all these questions permits us to speak of the promise of research along the indicated lines and the need for expanding and deepening them.

It seems extremely probable that the selectivity of the cytotoxic action of many wellknown antiblastic preparations on tumors is associated precisely with differences in the structure and function of the plasma membranes of tumor and normal cells.

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  1. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, Moscow

    S. V. Geodakyan & V. A. Chernov

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  1. S. V. Geodakyan
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 11, No. 9, pp. 3–15, September, 1977.

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Geodakyan, S.V., Chernov, V.A. The role of the cell surface in the mechanism of the action of antineoplastic drugs (literature survey). Pharm Chem J 11, 1161–1171 (1977). https://doi.org/10.1007/BF00777727

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