Skip to main content
SpringerLink
Log in

Interactions in cytochrome oxidase: Functions and structure

  • Short Review
  • Published:
Journal of Bioenergetics and Biomembranes Aims and scope Submit manuscript

Abstract

Mitochondrial cytochromec oxidase is an exceedingly complex multistructural and multifunctional membranous enzyme. In this review, we will provide an overview of the many interactions of cytochrome oxidase, stressing developments not covered by the excellent monograph of Wikström, Krab, and Saraste (1981), and continuing into early 1983. First we describe its functions (both in the nominal sense, as a transporter of electrons between cytochromec and oxygen, and in its role in energy transduction). Then we describe its structure, emphasizing the protein (its structure as a whole, the number and stoichiometry of its subunits, their biosynthetic origin, and their interactions with each other, with other components of the enzyme complex, and with the membrane as a whole). Finally, we present a model in which the protein conformation serves as the focus for the dynamic interaction of its two major functions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

DCCD:

N,N′-dicyclohexylcarbodiimide

E m :

midpoint potential

EPR:

electron paramagnetic resonance

F1 :

soluble portion of the ATP synthetase complex

NMR:

nuclear magnetic resonance

PAGE:

polyacrylamide gel electrophoresis

SDS:

sodium dodecyl sulfate

SUPAGE:

SDS-urea-PAGE

References

  • Alexandre, A., Reynafarje, B., and Lehninger, A. L. (1978).Proc. Natl. Acad. Sci. USA 75, 5296–5300.

    Google Scholar 

  • Anderson, S., de Bruijn, M. H. L., Coulson, A. R., Eperon, I. C., Sanger, F., and Young, I. G. (1982).J. Mol. Biol. 156, 683–717.

    Google Scholar 

  • Antonini, E., Brunori, M., Colosimo, A., Greenwood, C., and Wilson, M. T. (1977).Proc. Natl. Acad. Sci. USA 74, 3128–3132.

    Google Scholar 

  • Ariano, B. H., and Azzi, A. (1980).Biochem. Biophys. Res. Commun. 93, 478–485.

    Google Scholar 

  • Awasthi, Y. C., Chuang, T. F., Keenan, T. W., and Crane, F. L. (1971).Biochim. Biophys. Acta 226, 45–52.

    Google Scholar 

  • Azzi, A. (1980).Biochim. Biophys. Acta 594, 231–252.

    Google Scholar 

  • Azzi, A., and Casey, R. P. (1979).Mol. Cell. Biochem. 28, 169–184.

    Google Scholar 

  • Azzone, G. F., Pozzan, T., and Di Virgilio, F. (1979).J. Biol. Chem. 254, 10206–10212.

    Google Scholar 

  • Barrell, B. G., Bankier, A. T., and Drouin, J. (1979).Nature (London) 282, 189–194.

    Google Scholar 

  • Beechey, R. B., Roberton, A. M., Holloway, C. T., and Knight, I. G. (1967).Biochemistry 6, 3867–3879.

    Google Scholar 

  • Beinert, H, Shaw, R. W., Hansen, R. E., and Hartzell, C. R. (1980).Biochim. Biophys. Acta 591, 458–470.

    Google Scholar 

  • Benga, G., Porumb, T., and Wrigglesworth, J. M. (1981).J. Bioenerg. Biomembr. 13, 269–283.

    Google Scholar 

  • Bernstein, J. D., Bucher, J. R., and Penniall, R. (1978).J. Bioenerg. Biomembr. 10, 59–74.

    Google Scholar 

  • Bertrand, H., and Collins, R. A. (1978).Mol. Gen. Genet. 166, 1–13.

    Google Scholar 

  • Bertrand, H., and Werner, S. (1979).Eur. J. Biochem. 98, 9–18.

    Google Scholar 

  • Bickar, D., Bonaventura, J., and Bonaventura, C. (1982).Biochemistry 21, 2661–2666.

    Google Scholar 

  • Biewald, R., and Buse, G. (1982).Hoppe-Seyler's Z. Physiol. Chem. 363, 1141–1153.

    Google Scholar 

  • Bill, K., and Azzi, A. (1982).Biochem. Biophys. Res. Commun. 106, 1203–1209.

    Google Scholar 

  • Birchmeier, W. (1977).Mol. Cell Biochem. 14, 81–86.

    Google Scholar 

  • Birchmeier, W., Kohler, C. E., and Schatz, G. (1976).Proc. Natl. Acad. Sci. USA 73, 4334–4338.

    Google Scholar 

  • Bisson, R., and Montecucco, C. (1982).FEBS Lett 150, 49–53.

    Google Scholar 

  • Bisson, R., Gutweniger, H., and Azzi, A., (1978a).FEBS Lett. 92, 219–222.

    Google Scholar 

  • Bisson, R., Montecuco, C., Gutweniger, H., and Azzi, A. (1978b). InFrontiers of Biological Energetics (Dutton, P. L., Leigh, J. S., and Scarpa, A., eds.), Vol. 2, Academic Press, New York, pp. 809–816.

    Google Scholar 

  • Bisson, R., Montecucco, C., Gutweniger, H., and Azzi, A. (1979).Biochem. Soc. Trans. 7, 156–159.

    Google Scholar 

  • Bisson, R., Steffens, G. C. M., Capaldi, R. A., and Buse, G. (1982).FEBS Lett. 144, 359–363.

    Google Scholar 

  • Blair, D. F., Bocian, D. F., Babcock, G. T., and Chan, S. I. (1982).Biochemistry 21, 6928–6935.

    Google Scholar 

  • Blasie, J. K., Erecińska, M., Samuels, S., and Leigh, J. S. (1978).Biochim. Biophys. Acta 501, 33–52.

    Google Scholar 

  • Boelens, R., Wever, R., and Van Gelder, B. F. (1982).Biochim. Biophys. Acta 682, 264–272.

    Google Scholar 

  • Böhni, P. C., Daum, G., and Schatz, G. (1983).J. Biol. Chem. 258, 4937–4943.

    Google Scholar 

  • Bonitz, S. G., Coruzzi, G., Thalenfeld, B. E., Tzagoloff, A., and Macino, G. (1980).J. Biol. Chem. 255, 11927–11941.

    Google Scholar 

  • Borst, P., and Grivell, L. A. (1978).Cell 15, 705–723.

    Google Scholar 

  • Boyer, P. D. (1965). InOxidases and Related Redox Systems (King, T. E., Mason, H. S., and Morrison, M., eds.), Vol. 2, Wiley, New York, Vol. 2, pp. 994–1008.

    Google Scholar 

  • Boyer, P. D., Chance, B., Ernster, L., Mitchell, P., Racker, E., and Slater, E. C. (1977). Annu. Rev. Biochem.46, 955–1026.

    Google Scholar 

  • Briggs, M. M., and Capaldi, R. A. (1977).Biochemistry 16, 73–77.

    Google Scholar 

  • Briggs, M. M., and Capaldi, R. A. (1978).Biochem. Biophys. Res. Commun. 80 553–559.

    Google Scholar 

  • Briggs, M., Kamp, P.-F., Robinson, N. C., and Capaldi, R. A. (1975).Biochemistry 14 5123–5128.

    Google Scholar 

  • Brudvig, G. W., Stevens, T. H., Morse, R. H., and Chan, S. I. (1981).Biochemistry 20 3912–3921.

    Google Scholar 

  • Buse, G., and Steffens, G. J. (1978).Hoppe-Seyler's Z. Physiol. Chem. 359 1005–1009.

    Google Scholar 

  • Buse, G., Steffens, G. J., and Steffens, G. C. M. (1978).Hoppe-Seyler's Z. Physiol. Chem. 359 1011–1013.

    Google Scholar 

  • Cable, M. B., and Powell, G. L. (1980).Biochemistry 19 5679–5686.

    Google Scholar 

  • Capaldi, R. A., Bell, R. L., and Branchek, T. (1977).Biochem. Biophys. Res. Commun. 74 425–433.

    Google Scholar 

  • Capaldi, R. A., Darley-Usmar, V., Fuller, S., and Millett, F. (1982).FEBS Lett. 138 1–7.

    Google Scholar 

  • Carter, K., and Palmer, G. (1982).J. Biol. Chem. 257 13507–13514.

    Google Scholar 

  • Casey, R. P., and Azzi, A. (1983).FEBS Lett. 154 237–242.

    Google Scholar 

  • Casey, R. P., Chappell, J. B., and Azzi, A. (1979a).Biochem. J. 182 149–156.

    Google Scholar 

  • Casey, R. P., Thelen, M., and Azzi, A. (1979b).Biochem. Biophys. Res. Commun. 87 1044–1051.

    Google Scholar 

  • Casey, R. P., Thelen, M., and Azzi, A. (1980).J. Biol. Chem. 255 3994–4000.

    Google Scholar 

  • Caughey, W. S., Smythe, G. A., O'Keefe, D. H., Maskasky, J. E., and Smith, M. L. (1975).J. Biol. Chem. 250 7602–7622.

    Google Scholar 

  • Caughey, W. S., Wallace, W. J., Volpe, J. A., and Yoshikawa, S. (1976). InThe Enzymes, Vol. 13 (Boyer, P. D., ed.), Academic Press, New York, pp. 299–344.

    Google Scholar 

  • Cerletti, N., and Schatz, G. (1979).J. Biol. Chem. 254 7746–7751.

    Google Scholar 

  • Cerletti, N., Böhni, P. C., and Suda, K. (1983).J. Biol. Chem. 258 4944–4949.

    Google Scholar 

  • Chan, S. H. P., and Tracy, R. P. (1978).Eur. J. Biochem. 89 595–605.

    Google Scholar 

  • Chan, S. H. P., and Freedman, J. A. (1983).FEBS Lett. 162 344–348.

    Google Scholar 

  • Chance, B. (1981).Curr. Top. Cell. Regul. 18 343–360.

    Google Scholar 

  • Chance, B., and Waring, A. (1979). InCytochrome Oxidase (King, T. E., Orii, Y., Chance, B., Okunuki, K., eds.), Elsevier/North-Holland, Amsterdam, pp. 353–360.

    Google Scholar 

  • Chance, B., Erecińska, M., and Lee, C. P. (1970).Proc. Natl. Acad. Sci. USA 66 928–935.

    Google Scholar 

  • Chance, B., Saronio, C., and Leigh, J. S. (1975).J. Biol. Chem. 250 9226–9237.

    Google Scholar 

  • Chuang, T. F., and Crane, F. L. (1973).Bioenergetics 4 563–578.

    Google Scholar 

  • Clore, G. M., and Chance, E. M. (1979).Biochem. J. 177 613–621.

    Google Scholar 

  • Curuzzi, G., and Tzagoloff, A. (1979).J. Biol. Chem. 254 9324–9330.

    Google Scholar 

  • Darley-Usmar, V. M., and Fuller, S. D. (1981).FEBS Lett. 135 164–167.

    Google Scholar 

  • Darley-Usmar, V. M., Capaldi, R. A., and Wilson, M. T. (1981).Biochem. Biophys. Res. Commun. 103 1223–1230.

    Google Scholar 

  • De La Salle, H., Jacq, C., and Slonimski, P. P. (1982).Cell 28 721–732.

    Google Scholar 

  • De Pierre, J. W., and Ernster, L. (1977).Annu. Rev. Biochem. 46 201–262.

    Google Scholar 

  • Deatherage, J. F., Henderson, R., and Capaldi, R. A. (1982a).J. Mol. Biol. 158 487–499.

    Google Scholar 

  • Deatherage, J. F., Henderson, R., and Capaldi, R. A. (1982b).J. Mol. Biol. 158 501–514.

    Google Scholar 

  • Dockter, M. E., Steinemann, A., and Schatz, G. (1978).J. Biol. Chem. 253 311–317.

    Google Scholar 

  • Downer, N. W., Robinson, N. C., and Capaldi, R. A. (1976).Biochemistry 15 2930–2936.

    Google Scholar 

  • Erecińska, M. (1977).Biochem. Biophys. Res. Commun. 76 495–501.

    Google Scholar 

  • Erecińska, M., and Wilson, D. F. (1978).Arch. Biochem. Biophys. 188 1–14.

    Google Scholar 

  • Erecińska, M., Oshino, R., and Wilson, D. F. (1980).Biochem. Biophys. Res. Commun. 92 743–748.

    Google Scholar 

  • Eytan, G. D., and Schatz, G. (1975).J. Biol. Chem. 250 767–774.

    Google Scholar 

  • Eytan, G. D., Carrol, R. C., Schatz, G., and Racker, E. (1975).J. Biol. Chem. 250 8598–8603.

    Google Scholar 

  • Falk, K.-E., and Karlsson, B. (1979).FEBS Lett. 98 25–28.

    Google Scholar 

  • Ferguson, S. J. (1982).FEBS Lett. 146 239–243.

    Google Scholar 

  • Forman, N. G., and Wilson, D. F. (1982).J. Biol. Chem. 257 12908–12915.

    Google Scholar 

  • Fox, T. D. (1979).Proc. Natl. Acad. Sci. USA 76 6534–6538.

    Google Scholar 

  • Fox, T. D., and Leaver, C. J. (1981).Cell 26 315–323.

    Google Scholar 

  • Freedman, J. A., and Chan, S. H. P. (1978).Mol. Cell. Biochem. 19 135–146.

    Google Scholar 

  • Freedman, J. A., and Chan, S. H. P. (1983).J. Biol. Chem. 258 5885–5892.

    Google Scholar 

  • Freedman, J. A., Tracy, R. P., and Chan, S. H. P. (1979).J. Biol. Chem. 254 4305–4308.

    Google Scholar 

  • Frey, G., and Chan, S. H. P. (1980). InElectron Microscopy at Molecular Dimensions (Baumeister, W., and Vogell, W., eds.), Springer-Verlag, New York, pp. 81–90.

    Google Scholar 

  • Frey, T. G., Chan, S. H. P., and Schatz, G. (1978).J. Biol. Chem. 253 4389–4395.

    Google Scholar 

  • Frey, T. G., Costello, M. J., Karlsson, B., Haselgrove, J. C., and Leigh, J. S. (1982).J. Mol. Biol. 162 113–130.

    Google Scholar 

  • Fry, M., and Green, D. E. (1980).Biochem. Biophys. Res Commun. 93 1238–1246.

    Google Scholar 

  • Fukumori, Y., and Yamanaka, T. (1982).Biochim. Biophys. Acta 681 305–311.

    Google Scholar 

  • Fuller, S., Capaldi, R. A., and Henderson, R. (1979).J. Mol. Biol. 134 305–327.

    Google Scholar 

  • Fuller, S. D., Darley-Usmar, V. M., and Capaldi, R. A. (1981).Biochemistry 20 7046–7053.

    Google Scholar 

  • Gasser, S. M., Daum, G., and Schatz, G. (1982).J. Biol. Chem. 257 13034–13041.

    Google Scholar 

  • Georgevich, G., and Capaldi, R. A. (1982).Biophys. J. 37 66–67.

    Google Scholar 

  • Goormaghtigh, E., Brasseur, R., and Ruysschaert, J.-M. (1982).Biochem. Biophys. Res. Commun. 104 314–320.

    Google Scholar 

  • Greenaway, F. T., Chan, S. H. P., and Vincow, G. (1977).Biochim. Biophys. Acta 490 62–78.

    Google Scholar 

  • Gregor, I., and Tsugita, A. (1982).J. Biol. Chem. 257 13081–13087.

    Google Scholar 

  • Griffin, D. C., and Landon, M. (1981).Biochem. J. 197 333–344.

    Google Scholar 

  • Griffith, O. H., Jost, P., Capaldi, R. A., and Vanderkooi, G. (1973).Ann. N.Y. Acad. Sci. 222 561–573.

    Google Scholar 

  • Gutteridge, S., Winter, D. B., Bruyninckx, W. J., and Mason, H. S. (1977).Biochem. Biophys. Res. Commun. 78 945–951.

    Google Scholar 

  • Gutweniger, H., Bisson, R., and Montecucco, C. (1981).Biochim. Biophys. Acta 635 187–193.

    Google Scholar 

  • Gwak, S. H., and Powell, G. L. (1982).Biophys. J. 37 108–109.

    Google Scholar 

  • Hagen, W. R. (1982).Biochim. Biophys. Acta 708 82–98.

    Google Scholar 

  • Harmon, H. J., Hall, J. D., and Crane, F. L. (1974).Biochim. Biophys. Acta 344 119–155.

    Google Scholar 

  • Hatalová, I., and Kolarov, J. (1983).Biochem. Biophys. Res. Commun. 110 132–139.

    Google Scholar 

  • Huang, C. H., Keyhani, E., and Lee, C. P. (1973).Biochim. Biophys. Acta 305 455–473.

    Google Scholar 

  • Jarausch, J., and Kadenbach, B. (1982).Hoppe-Seyler's Z. Physiol. Chem. 363 1133–1140.

    Google Scholar 

  • Kadenbach, B., and Merle, P. (1981).FEBS Lett. 135 1–11.

    Google Scholar 

  • Kadenbach, B., Hartmann, R., Glanville, R., and Buse, G. (1982).FEBS Lett. 138 236–238.

    Google Scholar 

  • Kang, S. Y., Gutowsky, H. S., Hsung, J. C., Jacobs, R., King, T. E., Rice, D., and Oldfield, E. (1979).Biochemistry 18 3257–3267.

    Google Scholar 

  • Karlsson, B., and Andréasson, L.-E., (1981).Biochim. Biophys. Acta 635 73–80.

    Google Scholar 

  • Keilin, D. (1966).The History of Cell Respiration and Cytochrome (prepared by Keilin, J.), Cambridge University Press, Cambridge.

    Google Scholar 

  • Keilin, D., and Hartree, E. F. (1939).Proc. R. Soc. London B 127 167–191.

    Google Scholar 

  • Kent, T. A., Münck, E., Dunham, W. R., Filter, W. F., Findling, K. L., Yoshida, T., and Fee, J. A. (1982).J. Biol. Chem. 257 12489–12492.

    Google Scholar 

  • Keyhani, J., and Keyhani, E. (1978). InFrontiers of Biological Energetics (Dutton, P. L., Leigh, J. S., and Scarpa, A., eds.), Vol. 2, Academic Press, New York, pp. 913–921.

    Google Scholar 

  • Kinosita, K. Jr, Kawato, S., Ikegami, A., Yoshida, S., and Orii, Y. (1981).Biochim. Biophys. Acta 647 7–17.

    Google Scholar 

  • Knowles, P. F., Watts, A., and Marsh, D. (1981).Biochemistry. 20 5888–5894.

    Google Scholar 

  • Koch, G. (1976).J. Biol. Chem. 251 6097–6107.

    Google Scholar 

  • Kornblatt, J. A., and Lake, D. F. (1980).Can. J. Biochem. 58 219–224.

    Google Scholar 

  • Kornblatt, J. A., Chen, W. L., Hsia, J. C., and Williams, G. R. (1975).Can. J. Biochem. 53 364–370.

    Google Scholar 

  • Krab, K., and Wikström, M. (1978).Biochim. Biophys. Acta 504 200–214.

    Google Scholar 

  • Krab, K., and Wikström, M. (1979).Biochim. Biophys. Acta 548 1–15.

    Google Scholar 

  • Krebs, J. J. R., Hauser, H., and Carafoli, E. (1979).J. Biol. Chem. 254 5308–5316.

    Google Scholar 

  • Lemberg, M. R. (1969).Phys. Rev. 49 48–121.

    Google Scholar 

  • Lewin, A. S., Gregor, I., Mason, T. L., Nelson, N., and Schatz, G. (1980).Proc. Natl. Acad. Sci. USA 77 3998–4002.

    Google Scholar 

  • Lorusso, M., Capuano, F., Boffoli, D., Stefanelli, R., and Papa, S. (1979).Biochem. J. 182 137–147.

    Google Scholar 

  • Ludwig, B. (1980).Biochim. Biophys. Acta 594 177–189.

    Google Scholar 

  • Ludwig, B., Downer, N. W., and Capaldi, R. A. (1979).Biochemistry 18 1401–1407.

    Google Scholar 

  • Maccecchini, M.-L., Rudin, Y., Blobel, G., and Schatz, G. (1979).Proc. Natl. Acad. Sci. USA 76 343–347.

    Google Scholar 

  • MacLennan, D. H., and Tzagoloff, A. (1965).Biochim. Biophys. Acta 96 166–168.

    Google Scholar 

  • Malatesta, F., and Capaldi, R. (1982).Biochem. Biophys. Res. Commun. 109 1180–1185.

    Google Scholar 

  • Malmström, B. G. (1974).Q. Rev. Biophys. 6 389–431.

    Google Scholar 

  • Malmström, B. G. (1979).Biochim. Biophys. Acta 549 281–303.

    Google Scholar 

  • Margulis, L. (1970).Origin of Eukaryotic Cells Yale University Press, New Haven, Connecticut.

    Google Scholar 

  • Merle, P., and Kadenbach, B. (1980).Eur. J. Biochem. 105 499–507.

    Google Scholar 

  • Merle, P., and Kadenbach, B. (1982).Eur. J. Biochem. 125 239–244.

    Google Scholar 

  • Millett, F., Darley-Usmar, V., and Capaldi, R. A. (1982).Biochemistry 21 3857–3862.

    Google Scholar 

  • Mitchell, P. (1966).Biol. Rev. 41 445–502.

    Google Scholar 

  • Mitchell, P. (1976).Biochem. Soc. Trans. 4 399–430.

    Google Scholar 

  • Mitchell, P. (1979a).Eur. J. Biochem. 95 1–20.

    Google Scholar 

  • Mitchell, P. (1979b).Science 206 1148–1159.

    Google Scholar 

  • Mitchell, P., and Moyle, J. (1983).FEBS Lett. 151 167–178.

    Google Scholar 

  • Moss, T. H., Shapiro, E., King, T. E., Beinert, H., and Hartzell, C. (1978).J. Biol. Chem. 253 8072–8073.

    Google Scholar 

  • Moyle, J., and Mitchell, P. (1978).FEBS Lett. 88 268–272.

    Google Scholar 

  • Nagasawa-Fujimori, H., Nagasawa, T., and Heinrich, P. C. (1980).Biochim. Biophys. Acta 589 336–345.

    Google Scholar 

  • Nargang, F. E., Bertrand, H., and Werner, S. (1979).Eur. J. Biochem. 102 297–307.

    Google Scholar 

  • Nelson, N., and Schatz, G. (1979).Proc. Natl. Acad. Sci. USA 76 4365–4369.

    Google Scholar 

  • Netter, P., Jacq, C., Carignani, G., and Slonimski, P. P. (1982).Cell 28 733–738.

    Google Scholar 

  • Nicholls, P., and Chanady, G. A. (1982).Biochem J. 203 541–549.

    Google Scholar 

  • Nicholls, P., and Petersen, L. C. (1974).Biochim. Biophys. Acta 357 462–467.

    Google Scholar 

  • Nicholls, P., Proteau, G., and Wrigglesworth, J. M. (1982).J. Physiol. (London) 326, 12P.

    Google Scholar 

  • Northemann, W., Schmelzer, E., and Heinrich, P. C. (1981).Eur. J. Biochem. 119 203–208.

    Google Scholar 

  • Ohnishi, T., LoBrutto, R., Salerno, J. C., Bruckner, R. C., and Frey, T. G. (1982).J. Biol. Chem. 257 14821–14825.

    Google Scholar 

  • Ondrias, M. R., and Babcock, G. T. (1980).Biochem. Biophys. Res. Commun. 93 29–35.

    Google Scholar 

  • Ozawa, T., Tanaka, M., and Wakabayashi, T. (1982).Proc. Natl. Acad. Sci. USA 79 7175–7179.

    Google Scholar 

  • Paddy, M. R., Dahlquist, F. W., Davis, J. H., and Bloom, M. (1981).Biochemistry 20 3152–3162.

    Google Scholar 

  • Papa, S. (1976).Biochim. Biophys. Acta 456 39–84.

    Google Scholar 

  • Papa, S. (1982).J. Bioenerg. Biomembr. 14 69–86.

    Google Scholar 

  • Parimoo, S., Rao, N., and Padmanban, G. (1982).Biochem. J. 208 505–507.

    Google Scholar 

  • Penttilä, T., Saraste, M., and Wikström, M., (1979).FEBS Lett. 101 295–300.

    Google Scholar 

  • Powers, L., Chance, B., Ching, Y., and Angiolillo, P. (1981).Biophys. J. 34 465–498.

    Google Scholar 

  • Powers, L., Chance, B., Ching, Y., Muhoberac, B., Weintraub, S. T., and Wharton, D. C. (1982).FEBS Lett. 138 245–248.

    Google Scholar 

  • Poyton, R. O. (1980).Curr. Top. Cell. Regul. 17 231–294.

    Google Scholar 

  • Poyton, R. O., and Kavanagh, J. (1976).Proc. Natl. Acad. Sci. USA 73 3947–3951.

    Google Scholar 

  • Poyton, R. O., and McKemmie, E. (1979a).J. Biol. Chem. 254 6763–6771.

    Google Scholar 

  • Poyton, R. O., and McKemmie, E. (1979b).J. Biol. Chem. 254 6772–6780.

    Google Scholar 

  • Poyton, R. O., and Schatz, G. (1975a).J. Biol. Chem. 250 752–761.

    Google Scholar 

  • Poyton, R. O., and Schatz, G. (1975b).J. Biol. Chem. 250 762–766.

    Google Scholar 

  • Poyton, R. O., McKemmie, E., and George-Nascimento, C. (1978).J. Biol. Chem. 253 6303–6306.

    Google Scholar 

  • Prochaska, L., Bisson, R., and Capaldi, R. A. (1980).Biochemistry 19 3174–3179.

    Google Scholar 

  • Prochaska, L., Bisson, R., Capaldi, R. A., Steffens, G. C. M., and Buse, G. (1981).Biochim. Biophys. Acta 637 360–373.

    Google Scholar 

  • Reed, C. A., and Landrum, J. T. (1979).FEBS Lett. 106 265–267.

    Google Scholar 

  • Reid, G. A., and Schatz, G. (1982).J. Biol. Chem. 257 13062–13067.

    Google Scholar 

  • Reimer, N. S., Yosunobu, K. T., Wei, Y.-H., and King, T. E., (1983).Biochem. Biophys. Res. Commun. 110 8–14.

    Google Scholar 

  • Reinhammar, B., Malkin, R., Jensen, P., Karlsson, B., Andréasson, L.-E., Aasa, R., Vänngård, T., and Malström, B. G. (1980).J. Biol. Chem. 255 5000–5003.

    Google Scholar 

  • Reynafarje, B., Alexandre, A., Davis, P., and Lehninger, A. L. (1982).Proc. Natl. Acad. Sci. USA 79 7218–7222.

    Google Scholar 

  • Ries, G., Hundt, E., and Kadenbach, B. (1978).Eur. J. Biochem. 91 179–191.

    Google Scholar 

  • Robinson, N. C. (1982a).Biochemistry 21 184–188.

    Google Scholar 

  • Robinson, N. C. (1982b).Biophys. J. 37 65–66.

    Google Scholar 

  • Robinson, N. C., Strey, F., and Talbert, L. (1980).Biochemistry 19 3656–3661.

    Google Scholar 

  • Sachar, R., Steffens, G. J., and Buse, G. (1979).Hoppe-Seyler's Z. Physiol. Chem. 360 1385–1392.

    Google Scholar 

  • Saraste, M., Penttilä, T., Coggins, J. R., and Wikström, M. (1980).FEBS Lett. 114 35–38.

    Google Scholar 

  • Schatz, G. (1979).FEBS Lett. 103 203–211.

    Google Scholar 

  • Schatz, G., and Mason, T. L. (1974).Annu. Rev. Biochem. 43 51–87.

    Google Scholar 

  • Schmelzer, E., Northemann, W., Kadenbach, B., and Heinrich, P. C. (1982).J. Biochem. 127 177–183.

    Google Scholar 

  • Schneider, D. L., Kagawa, Y., and Racker, E. (1972).J. Biol. Chem. 247 474–4097.

    Google Scholar 

  • Seelig, A., and Seelig, J. (1978).Hoppe-Seyler's Z. Physiol. Chem. 359 1747–1756.

    Google Scholar 

  • Seiter, C. H. A., and Angelos, S. G. (1980).Proc. Natl. Acad. Sci. USA 77 1806–1808.

    Google Scholar 

  • Seiter, C. H. A., Margalit, R., and Perreault, R. A. (1979).Biochem. Biophys. Res. Commun. 86 473–477.

    Google Scholar 

  • Sigel, E., and Carafoli, E. (1978).Eur. J. Biochem. 89 119–123.

    Google Scholar 

  • Sigel, E., and Carafoli, E. (1979).J. Biol. Chem. 254 10572–10574.

    Google Scholar 

  • Singer, S. J., and Nicolson, G. L. (1972).Science 175 720–731.

    Google Scholar 

  • Slater, E. C. (1953).Nature (London) 172 975–978.

    Google Scholar 

  • Sone, N., and Yanagita, Y., (1982).Biochim. Biophys. Acta 682 216–226.

    Google Scholar 

  • Sorgato, M. C., and Ferguson, S. J. (1978).FEBS Lett. 90 178–182.

    Google Scholar 

  • Speck, S. H., Koppenol, W. H., Osheroff, N., Dethmers, J. K., Kang, C. H., Margoliash, E., and Ferguson-Miller, S. (1979). InMembrane Bioenergetics (Lee, C. P., Schatz, G., and Ernster, L., eds), Addison-Wesley, Reading, Massachusetts, pp. 31–43.

    Google Scholar 

  • Steffens, G. C. M., Steffens, G. J., and Buse, G. (1979).Hoppe-Seyler's Z. Physiol. Chem. 360 1641–1650.

    Google Scholar 

  • Steffens, G. J., and Buse, G. (1979).Hoppe-Seyler's Z. Physiol. Chem. 360 613–619.

    Google Scholar 

  • Steffens, G., and Buse, G. (1976).Hoppe-Seyler's Z. Phys. Chem. 357 1125–1137.

    Google Scholar 

  • Stevens, T. H., Martin, C. T., Wang, H., Brudvig, G. W., Scholes, C. P., and Chan, S. I. (1982).J. Biol. Chem. 257 12106–12113.

    Google Scholar 

  • Suissa, M., and Schatz, G. (1982).J. Biol. Chem. 257 13048–13055.

    Google Scholar 

  • Swank, R. T., and Munkres, K. D. (1971).Anal. Biochem. 39 462–477.

    Google Scholar 

  • Swanson, M. S., Qintanilha, A. T., and Thomas, D. D. (1980).J. Biol. Chem. 255 7494–7502.

    Google Scholar 

  • Tanaka, M., Haniu, M., Yasunobu, K. T., Yu, C.-A., Yu, L., Wei, Y.-H., and King, T. E. (1977).Biochem. Biophys. Res. Commun. 76 1014–1019.

    Google Scholar 

  • Tanaka, M., Haniu, M., Yasunobu, K. T., Yu, C.-A., Yu, L., Wei, Y.-H., and King, T. E. (1979).J. Biol. Chem. 254 3879–3885.

    Google Scholar 

  • Thalenfeld, B. E., and Tzagoloff, A. (1980).J. Biol. Chem. 255 6173–6180.

    Google Scholar 

  • Thompson, D. A., Suárez-Villafane, M., and Ferguson-Miller, S. (1982).Biophys. J. 37 285–296.

    Google Scholar 

  • Thomson, A. J., Englinton, D. G., Hill, B. C., and Greenwood, C. (1982).Biochem. J. 207 167–170.

    Google Scholar 

  • Tracy, R. P. (1978). Ph.D. Dissertation, Syracuse University, Syracuse, New York.

    Google Scholar 

  • Tracy, R. P., and Chan, S. H. P. (1979).Biochim. Biophys. Acta 576 109–117.

    Google Scholar 

  • Tweedle, M. F., Wilson, L. J., Gárcia-Iniguez, L., Babcock, G. T., and Palmer, G. (1978).J. Biol. Chem. 253 8065–8071.

    Google Scholar 

  • Van Gelder, B. F., and Beinert, H. (1969).Biochim. Biophys. Acta 189 1–24.

    Google Scholar 

  • Van't Sant, P., Mak, J. F. C., and Kroon, A. M. (1981).Eur. J. Biochem. 121 21–26.

    Google Scholar 

  • Verheul, F. E. A. M., Boonman, J. C. P., Draijer, J. W., Muijsers, A. O., Borden, D., Tarr, G. E., and Margoliash, E. (1979).Biochim. Biophys. Acta 548 397–416.

    Google Scholar 

  • Verheul, F. E. A. M., Draijer, J. W., Dentener, I. K., and Muijsers, A. O. (1981).Eur. J. Biochem. 119 401–408.

    Google Scholar 

  • Wainio, W. W. (1983). Biol. Rev.58 131–156.

    Google Scholar 

  • Weber, K., and Osborn, M. (1969).J. Biol. Chem. 244 4406–4412.

    Google Scholar 

  • Werner, S., and Bertrand, H. (1979).Eur. J. Biochem. 99 463–470.

    Google Scholar 

  • Wielburski, A., Kuźela, S., and Nelson, B. D. (1982).Biochem. J. 204 239–245.

    Google Scholar 

  • Wikström, M. K. F. (1977).Nature (London) 266 271–273.

    Google Scholar 

  • Wikström, M., and Krab, K. (1978).FEBS Lett. 91 8–14.

    Google Scholar 

  • Wikström, M. K. F., and Saari, H. T. (1977).Biochim. Biophys. Acta 462 347–361.

    Google Scholar 

  • Wikström, M. K. F., Harmon, H. J., Ingledew, W. J., and Chance, B., (1976).FEBS Lett. 65 259–277.

    Google Scholar 

  • Wikström, M., Krab, K., and Saraste, M. (1981).Cytochrome Oxidase. A Synthesis, Academic Press, London.

    Google Scholar 

  • Wilson, D. F., Lindsay, J. G., and Brocklehurst, E. S. (1972).Biochim. Biophys. Acta 256 277–286.

    Google Scholar 

  • Wilson, M. T., Jensen, P., Aasa, R., Malmström, B. G., Vänngård, T. (1982).Biochem. J. 203 483–492.

    Google Scholar 

  • Winter, D. B., Bruyninckx, W. J., Foulke, F. G., Grinich, N. P., and Mason, H. S. (1980).J. Biol. Chem. 255 11408–11414.

    Google Scholar 

  • Yatscoff, R. W., Freeman, K. B., and Vail, W. J. (1977).FEBS Lett. 81 7–9.

    Google Scholar 

  • Yu, C.-A., Yu, L. (1977).Biochim. Biophys. Acta 495 248–259.

    Google Scholar 

  • Yu, C.-A., Yu, L., and King, T. E. (1977).Biochem. Biophys. Res. Commun. 74 670–676.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biology, Syracuse University, 13210, Syracuse, New York

    Jo A. Freedman & Samuel H. P. Chan

Authors
  1. Jo A. Freedman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Samuel H. P. Chan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Freedman, J.A., Chan, S.H.P. Interactions in cytochrome oxidase: Functions and structure. J Bioenerg Biomembr 16, 75–100 (1984). https://doi.org/10.1007/BF00743042

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00743042

Key words

Search

Navigation