Summary
We have studied an unusual, spontaneous, intradural extramedullary spinal cord tumor in 12 dogs. Animals presented with paraparesis and ataxia early in life (11/12 ranged from 6 to 38 months of age) suggesting that these tumors may be congenital. Various breeds of dogs were represented with four cases in German Shepherds and three in retrievers; there was no sex predisposition. Post-mortem examinations revealed a single intradural mass consistently located between T10 and L2, which produced extensive compression of the spinal cord. Metastasis was never observed and significant pathological changes in other organs were lacking. Microscopic examination revealed solid sheets of ovoid to fusiform cells interspersed with areas of acinar and tubular differentiation. Some areas were rarified and focal squamous metaplasia was observed. Ultrastructural features included the presence of a continuous basal lamina, junctional complexes, microvilli and occasional cilia at the apices of acinar complexes. Immunocytochemical studies did not support a neurectodermal origin. At least 13 case reports of this entity have been previously published and have been designated ependymomas, medulloepitheliomas and neuroepitheliomas. A recent case was diagnosed as a nephroblastoma and we feel that this is an interesting and provocative diagnosis. These tumors could result from remnants of renal primordium which becomes trapped between the dura and the developing spinal cord. However, firm evidence of such a histogenesis is not yet at hand.
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References
Akhtar M, Kott E, Brooks B (1977) Extrarenal Wilms' tumor. Cancer 40:3087–3091
Alguacil-Garcia A, Pettigrew NM, Sina AAF (1986) Secretory meningioma. A distinct subtype of meningioma. Am J Surg Pathol 10:102–111
Bridges CH, Storts RW, Read WK (1984) Spinal cord nephroblastoma in a dog. Proc Am Coll Vet Pathol 35:97
Chaffee VW (1977) Spinal cord ependymoma in a dog. Vet Med Small Anim Clin 72:1854–1857
Coombs SG, Marder RJ, Minna JD, Mulshine JL, Polovina MR, Rosen ST (1984) Immunohistochemical localization of the immunodominant differentiation antigen Lacto-N-Fucopentaose III in normal adult and fetal tissues. J Histochem Cytochem 32:982–988
Cordy DR (1984) Intracranial germinoma in a dog. Vet Pathol 21:357–358
Deck JHN (1969) Cerebral medulloepithelioma with maturation into ependymal cells and ganglion cells. J Neuropathol Exp Neurol 28:442–454
DeLahunta A (1983) Veterinary neuroanatomy and clinical neurology, 2nd edn. Saunders, Philadelphia
Dolman CL (1984) Ultrastructure of brain tumors and biopsies. A diagnostic atlas. Praeger, New York
Fankhauser R, Luginbuhl H, McGrath JT (1974) Tumours of the nervous system. Bull WHO 50:53–69
Goebel HH, Cravioto H (1972) Ultrastructure of human and experimental ependymomas. J Neuropathol Exp Neurol 31:54–71
Gonzalez-Crussi F (1984) Wilms' tumor (nephroblastoma) and related renal neoplasma of childhood. CRC Press, Florida
Hard GC, Fox RR (1984) Electron-microscopic analysis of nephroblastomas induced transplacentally in the IIIVO/J rabbit by a single dose of N-ethylnitrosourea. Am J Pathol 117:239–251
Karch SB, Urich H (1972) Medulloepithelioma: definition of an entity. J Neuropathol Exp Neurol 31:27–53
Kennedy FA, Indrieri RJ, Koestner A (1984) Spinal cord medulloepithelioma in a dog. J Am Vet Med Assoc 185:902–904
Koestner A, Swenberg JA, Wechsler W (1971) Transplacental production with ethylnitrosourea of neoplasms of the nervous system in Sprague-Dawley rats. Am J Pathol 63:37–56
Kuhajda FP, Offutt LE, Mendelsohn G (1983) The distribution of carcinoembryonic antigen in breast carcinoma. Cancer 52:1257–1264
Kuo T-T (1977) Observation of nervous tissue in a Wilms' tumor: its histogenetic significance. Cancer 39:1105–1108
Llombart-Bosch A, Peydro-Olaya A, Cerda-Nicolas M (1980) Presence of ganglion cells in Wilms' tumours: a review of the possible neuroepithelial origin of nephroblastoma. Histopathology 4:321–330
Luchtrath H, deLeon F, Giesen H, Gok Y (1984) Inguinal nephroblastoma. Virchows Arch [A] 405:113–118
Luttgen PJ, Bratton GR (1976) Spinal cord ependymoma: a case report. J Am Anim Hosp Assoc 12:788–791
Luttgen PJ, Braund KG, Brawner WR, Vandevelde M (1980) A retrospective study of twenty-nine spinal tumours in the dog and cat. J Small Anim Pract 21:213–226
Machotka SV, Lord PL, Whitney GD, White J (1983) Medulloepithelioma in the spinal cord of a dog. Proc Am Coll Vet Pathol 34:191
Magee F, Mah RG, Taylor GP, Dimmick JE (1987) Neural differentiation in Wilms' tumor. Hum Pathol 18:33–37
Rubinstein LJ (1972) Tumors of the central nervous system. In: Firminger HI (ed) Atlas of tumor pathology, fascicle 6. Washington DC
Rubinstein LJ (1982) Tumors of the central nervous system. In: Hartmann WH (ed) Atlas of tumor pathology, fascicle 6 [Suppl] Washington DC
Schiefer B, Dahme E (1962) Primäre Geschwulste des ZNS bei Tieren. Acta Neuropathol (Berl) 2:202–212
Sternberger LA (1979) Immunocytochemistry, 2nd edn. Wiley & Sons, New York
Summers BA, deLahunta A (1985) Cerebral angioendotheliomatosis in a dog. Acta Neuropathol (Berl) 68:10–14
Teuscher E, Cherrstrom EC (1974) Ependymoma of the spinal cord in a young dog. Schweiz Arch Tierheilkd 116:461–466
VandeVelde M, Fankhauser R, Luginbuhl H (1985) Immunocytochemical studies in canine neuroectodermal brain tumors. Acta Neuropathol (Berl) 66:111–116
Wright JA (1985) The pathological features associated with spinal tumours in 29 dogs. J Comp Pathol 95:549–557
Yamashima T (1985) Meningothelial rosettes in the canine subarachnoid space. Acta Neuropathol (Berl) 66:223–232
Zachary JF, O'Brien DP, Ely RW (1981) Intramedullary spinal ependymoma in a dog. Vet Pathol 18:697–700
Zaki FA (1977) Spontaneous central nervous system tumors in the dog. Vet Clin North Am 7:153–163
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Summers, B.A., deLahunta, A., McEntee, M. et al. A novel intradural extramedullary spinal cord tumor in young dogs. Acta Neuropathol 75, 402–410 (1988). https://doi.org/10.1007/BF00687794
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DOI: https://doi.org/10.1007/BF00687794