Summary
Combined cytometric studies and control of blood coagulation of a cold injury brain edema in the left parietal cortex (cortical layers I and II) of rabbits had the following results: a) Within the first 30 min after the lesion, a hypocoagulability was observed only in the cerebral vessels and significant correlations are limited to the changes between the nuclear size of endothelial, glial and nerve cells of the left, lesioned, cortical area. An increase, however, in the diameter of the cytoplasmic profiles of the endothelial cells and of the pericapillary glial end feet of the right cortical layer II can be interpreted as an early reaction of these cell types to the disturbed function of the lesioned cortical area. b) 60 min after the lesion there is a general hypercoagulability which is followed by a general hypocoagulability 12 hrs later. Endothelial, glial and nerve cells of the right hemisphere are more and more influenced by the increasing edema of the left hemisphere (for correlations see p. 16). It is suggested that the changes of permeability in the lesioned hemisphere locally affect blood coagulation and thus have an influence via the cerebral vessels on the function of nerve cell-glia complexes in the contralateral hemisphere.
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Zimmermann, P., Gagel, C., Zimmermann, H. et al. Kälteinduzierte Ödem- und Nekroseentwicklung im Parietalcortex von Kaninchen. Acta Neuropathol 29, 157–174 (1974). https://doi.org/10.1007/BF00684774
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DOI: https://doi.org/10.1007/BF00684774