Abstract
Genes encoding endogenous superantigens causing Tcrb-V3+ T-cell deletion co-segregate with mouse mammary tumor proviruses (Mtv),Mtv-3, Mtv-6, andMtv-13. In additionMtv-1 has been implicated in deletion of these T cells. We have examined levels of Tcrb-V3+ T cells andMtv integrations in the following off-spring and their parental strains, [(CBA-T6 × NZW)F1 × CBA], [(CBA × C3H/He)F1 × CBA], and [(B10.S (9R) × NOD]F1 mice. We show that a newMtv (Mtv-44) from NZW mice andMtv-1 from C3H/He mice cosegregate with genes encoding ligands for partial deletion of Tcrb-V3s+ T cells and that some NOD mice have an additionalMtv (Mtv-45) which is closely linked toMtv-3.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Acha-Orbea, H., Shakhov, A. N., Scarpellino, L., Kolb, E., Muller, V., Vessaz-Shaw, A., Fuchs, R., Blochlinger, K., Rollini, P., Billotte, J., Sarafidou, M., MacDonald, H. R., and Diggelman, H.: Clonal deletion of Vβ14-bearing T cells in mice transgenic for mammary tumour virus.Nature 350: 207–211, 1991
Acha-Orbea, H. and Palmer, E.: Mls — a retrovirus exploits the immune system.Immunol Today 12: 356–361, 1991
Choi, Y. W., Kappler, J. W., and Marrack, P.: A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumour virus.Nature 350: 203–207, 1991
Dyson, P. J., Knight, A. M., Fairchild, S., Simpson, E., and Tomonari, K.: Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomes.Nature 349: 531–532, 1991
Fairchild, S., Knight, A. M., Dyson, P. J., and Tomonari, K.: Cosegregation of a gene encoding a deletion ligand for Tcrb-V3+ T cells withMtv-3.Immunogenetics 34: 227–230, 1991
Frankel, W. N., Rudy, C., Coffin, J. M., and Huber, B. T.: Linkage ofMls genes to endogenous mammary tumour viruses of inbred mice.Nature 349: 526–528, 1991
Kappler, J. W., Roehm, N., and Marrack, P.: T cell tolerance by clonal elimination in the thymus.Cell 49: 273–280, 1987a
Kappler, J. W., Wade, T., White, J., Kushler, E., Blackman, M., Bill, J., Roehm, N., and Marrack, P.: A T-cell receptor Vβ segment that impacts reactivity to class II major histocompatibility complex product.Cell 49: 263–271, 1987b
Kipling, D. and Cooke, H. J.: Hypervariable ultra-long telomeres in mice.Nature 347: 400–402, 1990
Maniatis, T., Fritsch, E. F., and Sambrock, J.:Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1982
Marrack, P. and Kappler, J.: T cells can distinguish between allogeneic major histocompatibility complex products on different cell types.Nature 332: 840–843, 1988
Marrack, P., Kushnir, E., and Kappler, J.: A maternally inherited superantigen encoded by a mammary tumour virus.Nature 349: 524–526, 1991
McDuffie, M., Schweiger, D., Reitz, B., Ostrowska, A., Knight, A. M., and Dyson, P. J.: I-E-independent deletion of Vβ17a+ T cells byMtv-3a from the non-obese diabetic (NOD) mouse.J Immunol, in press, 1992
Peters, G., Placzek, M., Brookes, S., Kozak, C., Smith, R., and Dickson, C.: Characterization, chromosome assignment, and segregation analysis of endogenous proviral units of mouse mammary tumor virus.J Virol 59: 535–544, 1986
Pullen, A. M., Marrack, P., and Kappler, J. W.: The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens.Nature 335: 796–801, 1988
Pullen, A. M., Choi, Y., Kushnir, E., Kappler, J., and Marrack, P.: The open reading frames in the 3′ long terminal repeats of several mouse mammary tumor virus integrants encode Vβ3-specific superantigensJ Exp Med, in press, 1991
Todd, J. A., Aitman, T. J., Cornall, R. J., Ghosh, S., Hall, J. R. S., Hearne, C. M., Knight, A. M., Love, J. M., McAleer, M. A., Prins, J., Rodrigues, N., Lathrop, M., Pressey, A., DeLarato, N. H., Peterson, L. B., and Wicker, L. S.: Genetic analysis of auto-immune type I diabetes mellitus in mice.Nature 351: 542–547, 1991
Tomonari, K.: Tolerance in vivo and in vitro.Immunol Rev 116: 139–157, 1990a
Tomonari, K.: Linkage between Tcrb-V and a gene responsible for deletion of Tcrb-V11+ T cells.Immunogenetics 32: 60–62, 1990b
Tomonari, K. and Fairchild, S.: The genetic basis of negative selection of Vβ11+ T cells.Immunogenetics 33: 157–162, 1991
Tomonari, K. and Spencer, S.: Epitope-specific binding of CD8 regulates activation of T cells and induction of cytotoxicity.Int Immunol 2: 1189–1194, 1990
Woodland, D. L., Happ, M. P., Bill, J., and Palmer, E.: Requirement for co-tolerogenic gene products in the clonal deletion of I-E reactive T cell.Science 247: 964–967, 1990
Woodland, D. L., Happ, M. P., Gollob, K. J., and Palmer, E.: An endogenous retrovirus mediating deletion of αβ T cells?Nature 349: 529–530, 1991a
Woodland, D. L., Lund, F. E., Happ, M. P., Blackman, M. A., Palmer, E., and Corley, R. B.: Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci.J Exp Med 174: 1255–1258, 1991b
Author information
Authors and Affiliations
Additional information
Address correspondence and offprint requests to: K. Tomonari.
Rights and permissions
About this article
Cite this article
Fairchild, S., Rosenwasser, O.A., Dyson, P.J. et al. Tcrb-V3+3T-cell deletion and a new mouse mammary tumor provirus,Mtv-44 . Immunogenetics 36, 189–194 (1992). https://doi.org/10.1007/BF00661096
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00661096