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Electron microscopic studies on melanotic and amelanotic melanomas in xiphophorin fish

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Summary

Electron microscopic studies on heritable melanomas in platyfish-swordtail hybrids reveal that the slowly growing melanotic melanomas of both pigmented and albino hybrids consist of well-differentiated cells, whereas the very rapidly growing melanotic melanomas of pigmented hybrids and amelanotic melanomas of albino hybrids consist of incompletely differentiated cells. There seems to be a correlation between the degree of cytological differentiation of the melanoma cell and the rate of tumor growth.

Zusammenfassung

Es wurden elektronenmikroskopische Untersuchungen an genetisch bedingten Melanomen von Bastarden vonPlatypoecilus maculatus undXiphophorus helleri (Poeciliidae) durchgeführt. Langsam wachsende melanotische Melanome von pigmentierten sowie von albinotischen Bastarden bestehen aus gut differenzierten Melanocyten und Macromelanophoren, während schnell wachsende Melanome von pigmentierten Bastarden sowie amelanotische Melanome von albinotischen Bastarden aus unvollständig differenzierten Melanocyten bestehen. Der Grad der cytoplasmatischen Differenzierung der Melanomzellen ist daher mit der Wachstumsrate der Melanome korreliert.

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References

  • Gordon, M.: The genetics of a viviparous top minnowPlatypoecilus; the inheritance of two kinds of melanophores. Genetics12, 253–283 (1927).

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  • Vielkind, J.: Quantitative Bestimmung der Nucleinsäuren in Muskel- und Tumorgewebe von lebendgebärenden Zahnkarpfenbastarden (Poeciliidae). Diplomarbeit Universität Gießen, 1968.

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Supported by Deutsche Forschungsgemeinschaft and Stiftung Volkswagenwerk.

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Vielkind, J., Vielkind, U. & Anders, F. Electron microscopic studies on melanotic and amelanotic melanomas in xiphophorin fish. Z Krebs-forsch 75, 243–245 (1971). https://doi.org/10.1007/BF00641953

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  • DOI: https://doi.org/10.1007/BF00641953

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