Summary
Mineral transport to bone is dependant on an adequate blood supply. Thus, the role of vasoactive agents merits orthopaedic interest. This paper outlines the morphology of osteons and capillaries in cortical bone and discusses the possible morphological effects of systemic phenylephrine on mice tibiae. The frequency of dilated capillaries on histological serial sections did not significantly change. Hence, a postcapillary mechanism is likely to explain previous EM findings: i.e., an adrenaline-induced increase of the lumen diameter and perivascular cell edema.
Zusammenfassung
Da der Mineraltransport im Knochen von der Kapillardurchblutung in den Osteonen beeinflußt wird, haben gefäßaktive Substanzen orthopädische Bedeutung. Dieser Beitrag soll die Morphologie der Knochenkapillaren verdeutlichen und die Frage beantworten, ob Sympathomimetika die Häufigkeit durchströmter Kapillaren ändern können. Die quantitative Auswertung histologischer Serienschnitte von Mäuseknochen ergab keine signifikante Beeinflussung durch Phenylephrin. Im Hinblick auf elektronenmikroskopische Befunde scheinen postkapilläre Mechanismen den Blutfluß im Knochen zu regulieren.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Brookes M (1971) The blood supply of bone: an approach to bone biology. Butterworths, London
Cohen J, Harris WH (1958) The three-dimensionmal anatomy of haversian systems. J Bone Joint Surg [Am] 40:419–434
Cooper RR, Milgram JW, Robinson RA (1966) Morphology of the osteon. An electron-microscopic study. J Bone Joint Surg [Am] 48:1239–1271
Davies DR, Bassingthwaighte JB, Kelly PJ (1976) Transcapillary exchange of strontium and sucrose in canine tibia. J Appl Physiol 40:17–22
Döhler JR, Robertson S, Smith GD (1985) Bone capillaries under the influence of adrenaline. Ann R Coll Surg Engl (in press)
Gil J, McNiff JM (1984) Early cell alterations induced by histamine and epinephrine in rabbit lung. Am J Physiol 246:69–76
Hammersen F (1971) Anatomie der terminalen Strombahn: Muster, Feinbau, Funktion. Urban & Schwarzenberg, München Berlin Wien
Hughes SPF, Davies DR, Khan R, Kelly PJ (1978) Fluid space in bone. Clin Orthop 134:332–341
Hughes SPF, Blount M (1979) The structure of capillaries in cortical bone. Ann R Coll Surg Engl61:312
Innes R, Nickersen M (1970) Drugs acting on postganglionic adrenergic nerve endings and structures innervated by them (sympathomimetic drugs). In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, 4th edn. Macmillan, London Toronto, pp 500, 510
Knese KH (1979) Die Strukturentwicklung des Skeletts. In: Handbuch der mikroskopischen Anatomic des Menschen, Band 2/5. Springer, Berlin Heidelberg New York, pp 667–671
McCarthy ID, Hughes SPF (1983) The role of skeletal blood flow in determining the uptake of 99m Tc-methylene-diphosphonate. Calcif Tissue Int 35:508–511
Vetterlein F, Schmidt G (1984) Effects of propranolol and epinephrine on density of capillaries in rat heart. Am J Physiol 246:189–196
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Döhler, J.R., Robertson, S. & Hughes, S.P.F. The effect of sympathomimetic drugs on bone capillaries. Arch. Orth. Traum. Surg. 105, 62–65 (1986). https://doi.org/10.1007/BF00625663
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00625663