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The effect of acute saline volume expansion on renal Na−K-ATPase

  • Excitable Tissues and Central Nervous Physiology
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Abstract

To examine the role of Na-K-ATPase in the natriuresis that occurs after acute extracellular volume expansion, we performed acute clearance experiments and in vitro analysis of renal microsomal ATPase activity in rats receiving intravenous 0.9% sodium chloride (0.1 ml/100g bw/min). Despite increased absolute reabsorption of filtered sodium (196±8.1 vs. 165±11.4 uEq/min, p<0.05), renal medullary microsomal Na-K-ATPase activity was decreased from 134±5.9 to 110±6.3 pmol Pi/mg protein/hour (p<0.02). No changes occurred in cortical or papillary regions and Mg-ATPase was unaffected. Similar results were obtained after adding 4 mEq/l potassium chloride to the infusion to prevent any fall in serum K+. These data suggest that a considerable percentage of sodium reabsorption is suppressed in acutely volume expanded animals and it is proposed that this is mediated by inhibition of medullary Na-K-ATPase.

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Authors and Affiliations

  1. Nephrology Services, Hadassah University Hospital, POB 1200, 91120, Jerusalem, Israel

    Michael M. Friedlaender, Hanna Wald & Mordechai M. Popovtzer

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  1. Michael M. Friedlaender
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  2. Hanna Wald
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  3. Mordechai M. Popovtzer
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Friedlaender, M.M., Wald, H. & Popovtzer, M.M. The effect of acute saline volume expansion on renal Na−K-ATPase. Pflugers Arch. 405, 170–172 (1985). https://doi.org/10.1007/BF00584539

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  • DOI: https://doi.org/10.1007/BF00584539

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