Abstract
Active transport of A.I.B. from mother to fetus was studied. This was done in the intact animal and using the isolated placenta, artificially perfused at both sides. It was shown that A.I.B. is actively accumulated in the placental cells. An estimate of the kinetic constants is given. It is shown that this accumulation takes place predominantly from the maternal side of the placenta.
A.I.B. that has been accumulated is cleared to the maternal and fetal circulation in equal amounts. So the netto active transport from mother to fetus is brought about by an unequal distribution of carriers, the maternal side being most active.
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Christensen, H. N., Streicher, J. A.: Association between rapid growth and elevated cell concentration of amino acids. I. In fetal tissues. J. Biol. Chem.175, 95–102 (1948)
Christensen, H. N., Liang, M., Archer, F. G.: A distinct Na+-requiring transport system for alanine, serine, cysteine and similar amino acids. J. Biol. Chem.242, 5237–5246 (1967)
Dancis, J., Money, W. L., Springer, D., Levitz, M.: Transport of amino acids by placenta. Am. J. Obstet. Gynecol.101, 820–829 (1968)
Enders, R. H., Judd, R. M., Donohue, T. M., Smith, C. H.: Placental amino acid uptake. III. Transport systems for neutral amino acids. Am. J. Physiol.230, 706–710 (1976)
Gresham, E. L., Simons, P. S., Battaglia, F. C.: Maternal-fetal urea concentration difference in man: Metabolic significance. J. Pediat.79, 809–811 (1971)
Gresham, E. L., James, E. J., Raye, L. R., Battaglia, F. C., Makowski, E. L., Meschia, G.: Production and excretion of urea by the fetal lamb. Pediatrics50, 372–379 (1972)
Hill, P. M. M., Young, M.: Net placental transfer of free amino acids against varying concentrations. J. Physiol. (Lond.)235, 409–422 (1973)
Kastendieck, D., Moll, W.: The placental transfer of lactate and bicarbonate in the guinea pig. Pflügers Arch.370, 165–171 (1977)
Van Kreel, B. K., Van Dijk, J. P.: The influence of flow rates and flow distributions on diffusion controlled transport across the isolated guinea pig placenta. J. Comp. Physiol.115, 253–264 (1977)
Leichtweiss, H. P., Schröder, H.: Untersuchungen über den Glucose-transport durch die isolierte, beiderseits künstlich perfundierte Meerschweinchenplacenta. Pflügers Arch.325, 139–148 (1971)
Litonjua, A. D., Canlas, M., Soliman, J., Paulino, Q.: Uptake of α-aminoisobutyric acid in placental slices at term. Am. J. Obstet. Gynecol.99, 242–246 (1967)
Longo, L. D., Yuen, P., Gusseck, D. J.: Anaerobic, glycogen-dependent transport of amino acid by the placenta. Nature243, 531–533 (1973)
Miller, K. R., Berndt, W. O.: Characterization of neutral amino acid accumulation by human term placental slices. Am. J. Physiol.227, 1236–1242 (1974)
Oxender, D. J., Christensen, H. N.: Transcellular concentration as a consequence of intracellular accumulation. J. Biol. Chem.234, 2321–2324 (1959)
Oxender, D. J., Christensen, H. N.: Distinct mediating systems for transport of neutral amino acids by the Ehrlich cell. J. Biol. Chem.238, 3683–3699 (1963)
Romualdes, A. G., Litonjua, A. D.: Amino acid uptake by human placental slices. Am. J. Obstet. Gynecol.109, 1225–1231 (1971)
Schneider, H., Dancis, J.: Amino acid transport in human placental slices. Am. J. Obstet. Gynecol.120, 1092–1098 (1974)
Smith, C. H., Adcock, E. W., Teasdale, F., Meschia, G., Battaglia, F. C.: Placental amino acid uptake: tissue preparation, kinetics and preincubation effect. Am. J. Physiol.224, 558–564 (1973)
Smith, C. H., Depper, R.: Placental amino acid uptake. II. Tissue preincubation, fluid distribution and mechanisms of regulation. Pediatr. Res.8, 697–703 (1974)
Sybulski, M., Tremblay, P. C.: Uptake and incorporation into protein of radioactive glycine by human placentas in vitro. Am. J. Obstet. Gynecol.97, 1111–1118 (1967)
Umbreit, W. W., Bursis, R. H., Stauffer, J. F.: Manometric techniques, 4th edition, p. 152. Minneapolis: Burgess 1968
Young, M., Prenton, M. A.: Maternal and foetal plasma amino acid concentrations during gestation and in retarded foetal growth. J. Obstet. Gynaecol. Br. Commonw.76, 333–344 (1969)
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van Dijk, J.P., van Kreel, B.K. Transport and accumulation of α-aminoisobutyric acid (A.I.B.) in the guinea pig placenta. Pflugers Arch. 377, 217–224 (1978). https://doi.org/10.1007/BF00584275
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DOI: https://doi.org/10.1007/BF00584275