Summary
The time course of the effect of cimetidine on the pharmacokinetics of metronidazole was investigated in 6 healthy volunteers.
Cimetidine 1.0 g/day was administered for 9-days and metronidazole 500 mg was administered orally on the second and eighth days, and in a control experiment.
During cimetidine treatment the plasma kinetics of metronidazole and its partial clearance by renal excretion of the unchanged compound, glucuronidation, hydroxylation and oxidation to its acetic acid metabolite were not significantly different from the control values.
The results indicate that cimetidine does not influence the pharmacokinetics or metabolism of a single oral dose of metronidazole.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Powell JR, Donn KH (1984) Histamine H2-antagonist drug interactions in perspective: Mechanistic concepts and clinical implications. Am J Med 77 [Suppl 5B]: 57–84
Ralph ED (1983) Pharmacokinetics of metronidazole. Clin Pharmacokinet 8: 43–62
Jensen JC, Gugler R (1983) Single and multiple-dose metronidazole kinetics. Clin Pharmacol Ther 34: 481–487
Loft S, Døssing M, Poulsen HE, Sonne J, Olesen KL, Simonsen K, Andreasen PB (1986) Influence of dose and route of administration on disposition of metronidazole and its major metabolites. Eur J Clin Pharmacol 30: 467–473
Loft S, Sonne J, Poulsen HE, Petersen KT, Jørgensen BG, Døssing M (1987) Inhibition and induction of metronidazole and antipyrine metabolism. Eur J Clin Pharmacol 32: 35–41
Gugler R, Jensen JC (1983) Interaction between cimetidine and metronidazole. N Engl J Med 309: 1518–1519
Loft S, Sonne J, Pilsgaard H, Døssing M, Poulsen HE (1986) Inhibition of antipyrine elimination by disulfiram and cimetidine: the effect of concomitant administration. Br J Clin Pharmacol 21: 75–77
Stockley C, Keal J, Rolan P, Bochner F, Somogyi A (1986) Lack of inhibition of tolbutamide hydroxylation by cimetidine in man. Eur J Clin Pharmacol 31: 235–237
Henauer SA, Hollister LE (1984) Cimetidine interaction with imipramine and nortriptyline. Clin Pharmacol Ther 35: 183–187
Choonara IA, Cholerton S, Haynes BP, Breckenridge AM, Park BK (1986) Stereoselective interaction between the R-enantiomer of warfarin and cimetidine. Br J Clin Pharmacol 21: 271–277
Begg EJ, Williams KM, Wade DN, O'Shea KF (1983) No significant effect of cimetidine on the pharmacokinetics of misonidazole in man. Br J Clin Pharmacol 15: 575–576
Slusher LB, Vesell ES (1984) Cimetidine-induced reduction in gastrointestinal absorption of antipyrine and rate constant for formation of its metabolites. Clin Pharmacol Ther 35: 568–575
Gachalyi B, Vas A, Csillag K, Nagy B, Kocsis F, Kaldor A (1987) Pharmacogenetic differences in the inhibitory effect of cimetidine on the metabolism of antipyrine. Eur J Clin Pharmacol 31: 613–615
Døssing M, Pilsgaard H, Rasmussen B, Poulsen HE (1983) Time course of phenobarbitone and cimetidine mediated changes in hepatic drug metabolism. Eur J Clin Pharmacol 25: 215–222
Adebayo GI, Coker AB (1987) Cimetidine inhibition of theophylline elimination: The influence of adult age and the time course. Biopharm Drug Disposit 8: 149–158
Crugten J, Bochner F, Keal J, Somogyi A (1986) Selectivity of cimetidine-induced alterations in the renal handling of organic substrates in humans. Studies with anionic, cationic and zwitterionic drugs. J Pharmacol Exp Ther 236: 481–487
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Loft, S., Døssing, M., Sonne, J. et al. Lack of effect of cimetidine on the pharmacokinetics and metabolism of a single oral dose of metronidazole. Eur J Clin Pharmacol 35, 65–68 (1988). https://doi.org/10.1007/BF00555509
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00555509