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The influence of lymph node metastasis and ulceration of primary melanoma on germinal centers within draining lymph nodes: A histomorphometric study

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Summary

Microscopic counts and histoelectronic measurement of germinal centers in regional lymph nodes of melanoma patients showed a significant progressive increase in average number, as well as area, of germinal centers with occurrence of (adjacent) metastasis and presence of primary-tumor ulceration. The findings confirm in a quantitative manner the stage-dependent effect of progressive liberation of tumor antigen [10] on lymph node centers of humoral immune response.

Zusammenfassung

Zahl und histoelektronisch gemessene Fläche der Keimzentren in regionalen Lymphknoten von Melanom-Patienten zeigen eine statistisch signifikante Zunahme mit dem Auftreten von (benachbarten) Metastasen und einer Ulceration des Primärtumors. Die Ergebnisse bekräftigen auf quantitativem Wege den Stadien-abhängigen Einfluß von zunehmend freiwerdendem Tumorantigen [10] auf die Zentren der humoralen Immunantwort im regionalen Lymphknoten.

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References

  1. Ambus U, Mavligit GM, Gutterman JU, McBridge CM, Hersh EM (1974) Specific and non-specific immunologic reactivity of regional lymph-node lymphocytes in human malignancy. Int J Cancer 14:291–300

    Google Scholar 

  2. Bystryn J-Cl (1980) The immunobiology of human malignant melanoma. Int J Dermatol 19:375–378

    Google Scholar 

  3. Gupta RK, Theofilopoulos AN, Dixon FJ, Morton DL (1979) Circulating immune complexes as possible cause for anticomplementary activity in humans with malignant melanoma. Cancer Immunol immunother 6:211–221

    Google Scholar 

  4. Hellström I, Hellström KE, Sjögren HO, Warner GA (1971) Serum factors in tumor-free patients cancelling the blocking of cell-mediated tumor immunity. Int J Cancer 8:185–191

    Google Scholar 

  5. Heppner GH, Stolbach L, Byrne M, Cummings FJ, McDonough E, Calabresi P (1973) Cell-mediated and serum-blocking reactivity to tumor antigens in patients with malignant melanoma. Int J Cancer 11:245–260

    Google Scholar 

  6. Hunter RL, Ferguson DJ, Coppleson LW (1975) Survival with mammary cancer related to the interaction of germinal center hyperplasia and sinus histiocytosis in axxillary and internal mammary lymph nodes. Cancer 36:528

    Google Scholar 

  7. Jaffe ES, Shevach EM, Frank MM, Berard CW, Green I (1974) Nodular lymphoma —evidence for origin from follicular B lymphocytes. N Engl J Med 290:813–819

    Google Scholar 

  8. Kolmogoroff AN (1933) Sulla determinazione empirica di una legge di distribuzione. Giornale Istituto Italiano Attuari 4:83–91

    Google Scholar 

  9. Lewis MG, Phillips TM, Rowden G, Jerry LM (1977) Humoral immune factors in metastasis in human cancer. In: Day SB, Laird Myers WP, Stansly P, Garattini S, Lewis MG (eds) Cancer invarsion and metastasis: Biologic mechanisms and therapy. Raven Press, New York, pp 245–258

    Google Scholar 

  10. Lewis MG, Phillips TM, Rowden G, MacDonald JS (1979) Immune derangement in patients with malignant melanoma. In: Kumar S (ed) Advances in medical oncology, research and education, Vol. 10. Pergamon Press, Oxford New York, pp 103–111

    Google Scholar 

  11. Murray E, McCarthy WH, Hersey P (1977) Blocking factors against leucocyte-dependent melanoma antibody in the sera of melanoma patients. Br J Cancer 36:7–14

    Google Scholar 

  12. Norris DA, Huff JC, Swinehart JM, Carr RI, Thorne EG, Weston WL, McIntosh RM (1980) Cryoglobulinemia and decreased monocyte chemotaxis in malignant melanoma. J Invest Dermatol 75:219–223

    Google Scholar 

  13. Olson JL, Phillips TM, Lewis MG, Solez K (1979) Malignant melanoma with renal dense deposits containing tumor antigen. Clin Nephrol 12:74–82

    Google Scholar 

  14. O'Toole C, Saxon A, Bohrer R (1977) Human lymph node lymphocytes fail to effect lysis of antibody-coated target cells. Clin Exp Immunol 27:165–171

    Google Scholar 

  15. Reich H (1970) Hautkrebs und regionale Lymphknoten. In: Gottron HA, Schönfeld W (eds) Dermatologie und Venerologie, Erg. Bd. Thieme, Stuttgart, pp 115–119

    Google Scholar 

  16. Silveira NPA, Mendes NF, Tolnai MEA (1972) Tissue localization of two populations of human lymphocytes distinguished by membrane receptors. J Immunol 108:1456–1460

    Google Scholar 

  17. Smirnoff NW (1939) On the estimation of the discrepancy between empirical curves of distribution for two independent samples. Bull Univ Moskov Ser Internat, Sect. A 2:3–8

    Google Scholar 

  18. Stingl G, Wolff K, Diem E, Baumgartner G, Knapp W (1977) In situ identification of lymphoreticular cells in benign and malignant infiltrates by membrane receptor sites. J Invest Dermatol 69:231–235

    Google Scholar 

  19. Weidner F (1979) Comparative histological studies of regional lymph nodes of 201 melanoma patients. Microscopic features in relation to individual age, site, and metastatic spread. Arch Dermatol Res 266:161–175

    Google Scholar 

  20. Weidner F, Tonak J (eds) (1981) Das maligne Melanom der Haut. Perimed, Erlangen

    Google Scholar 

  21. Wilcoxon F (1945) Individual comparisons by ranking methods. Biometrics 1:80–83

    Google Scholar 

  22. Zeromski J (1975) Behaviour of local and systemic immunoglobulins in patients with lung cancer. Int Arch Allergy (Basel) 49:548–563

    Google Scholar 

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  1. Dept. of Dermatology, University of Erlangen-Nuremberg, D-8520, Erlangen, Germany

    F. Weidner, S. Schroll & A. Schönberger

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  1. F. Weidner
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  2. S. Schroll
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  3. A. Schönberger
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Weidner, F., Schroll, S. & Schönberger, A. The influence of lymph node metastasis and ulceration of primary melanoma on germinal centers within draining lymph nodes: A histomorphometric study. Arch Dermatol Res 272, 155–161 (1981). https://doi.org/10.1007/BF00510408

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  • DOI: https://doi.org/10.1007/BF00510408

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