Summary
Toxicity of the mushroom cyclopeptide phalloidin decreases after partial hepatectomy. Nevertheless all morphological signs of intoxication are detectable in livers from dead or surviving animals.
References
Bakkeren, J. A. J. M., Bonting, S. L.: Studies on (Na+−K+)-activated ATPase. XXI. Changes in (Na+−K+)-activated ATPase activity and ouabain-sensitive 86Rb+ uptake rate in regenerating rat liver. Biochim. biophys. Acta (Amst.) 150, 467–472 (1968).
Fiume, L.: Mechanism of action of phalloidin. Lancet 1965I, 1284.
—, Laschi, R.: Lesioni ultrastructurali prodotte nelle cellule parenchimali epatiche dalla falloidina e dalla α-amanitina. Sperimentale 115, 288–297 (1965).
Frimmer, M., Gries, J., Hegner, D., Schnorr, B.: Studies of the mechanisms of the action of phalloidin. Release of enzymes and potassium. Naunyn-Schmiedebergs Arch. Pharmak. 258, 197 (1967).
Higgins, G. M., Anderson, R. M.: Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal. Arch. Path. 12, 186–202 (1931).
Miller, F., Wieland, O.: Elektronenmikroskopische Untersuchungen der Leber von Maus und Ratte bei akuter Phalloidin-Vergiftung. Virchows Arch. path. Anat. 343, 83–99 (1967).
Puchinger, H.: Zum Wirkungsmechanismus von Phalloidin und Antamanid. Inaug. Diss., Frankfurt a. M. 1968 (Naturwiss. Fak.).
Siess, E., Wieland, O., Miller, F.: Elektronemikroskopische Untersuchungen zur Phalloidintoleranz neugeborener Ratten, Mäuse und Kaninchen. Virchows Arch., Abt. B Zellpath. 6, 151–165 (1970).
Wieland, O., Szabanos, A.: On the nature of phalloidin tolerance in newborn rats VI. Internat. Kongr. Klin. Chemie, München 1966. Vol. 4: Advance in clinicobiochemical research, pp. 59–66. Basel-New York: S. Karger 1968.
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This work is supported by the Deutsche Forschungsgemeinschaft.
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Frimmer, M., Schischke, B. Decreased toxicity of phalloidin in partially hepatectomized rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 272, 447–449 (1972). https://doi.org/10.1007/BF00501251
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DOI: https://doi.org/10.1007/BF00501251