Summary
The vasodilator potency of different isomeric organic nitrates was tested on the perfused hindleg of the dog. The dinitrates and mononitrates of isosorbide, isomannide and isoidide have an increased potency if the nitrate groups are in the exo-position; for the mononitrates, potency is increased if the hydroxy group assumes the same position as the nitrate group.
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Bogaert, M.G., Rosseel, M.T. Vascular effects of the dinitrate and mononitrate esters of isosorbide, isomannide and isoidide. Naunyn-Schmiedeberg's Arch. Pharmacol. 275, 339–342 (1972). https://doi.org/10.1007/BF00500061
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DOI: https://doi.org/10.1007/BF00500061