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Compensatory neoplasia: Chronic erythrocytosis and neuroblastic tumors

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Abstract

There are a large number of exogenous biological and chemical substances with known neoplastic or carcinogenic potential. However, it has also been postulated that external stimuli can influence the body's internal milieu, and thereby induce compensatory excessive growth of cells in the form of hyperplasia or neoplasia. In a recent study, we observed a strong association between chronic hypoxic states and the occurrence of peripheral neuroblastic tumors, a relatively uncommon group of neural neoplasms. In this report we review those findings and formulate an hypothesis to explain why conditions which lead to chronic erythrocytosis may also cause compensatory neoplasia of neural tissues.

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Authors and Affiliations

  1. Department of Pathology, The Johns Hopkins Medical Institutions, 21205, Baltimore, Maryland, U.S.A.

    Suzanne M. de la Monte, Grover M. Hutchins & G. William Moore

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  1. Suzanne M. de la Monte
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  2. Grover M. Hutchins
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  3. G. William Moore
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Address correspondence and reprint requests to Professor Grover M. Hutchins, M.D., Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, 21205, U.S.A.

Supported by NIH Grants LM-03651 from the National Library of Medicine and HL-22963 from the National Heart, Lung and Blood Institute.

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de la Monte, S.M., Hutchins, G.M. & Moore, G.W. Compensatory neoplasia: Chronic erythrocytosis and neuroblastic tumors. Theor Med Bioeth 5, 279–291 (1984). https://doi.org/10.1007/BF00489476

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