Skip to main content
Log in

Ineffectiveness of vasopressin in the treatment of memory impairment in chronic schizophrenia

  • Original Investigations
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

A vasopressin derivative or placebo was administered to 21 chronic schizophrenia patients for 3 weeks in a randomized crossover double-blind design. The patients were divided into those above and below the median on baseline memory measured by the Wechsler memory scale. Vasopressin treatment did not improve memory either in those patients with below median baseline memory or in the group as a whole.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Boer GJ, Swaab HBM, Uylings K, Boer RM, Buijs RM, Vellis DN (1980) Neuropeptides in rat brain development. In: McConnell PS, Boer GJ, Romijn JH, Van de Poll NE, Corner MA (eds.) Progress in brain research vol. 53, Elsevier, North Holland, Biomedical Press, Amsterdam, pp 208–227

    Google Scholar 

  • Forizs L (1952) Treatment of mental patients with antidiuretic hormone of the posterior pituitary. Dis Nerv Syst 13:44–47

    Google Scholar 

  • Johnstone EC, Crow TJ, Frith CD, Husband J, Kreel L (1976) Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet 2:924–926

    Google Scholar 

  • Korsgaard S, Casey DE, Damgaard Pedersen NE, Jorgensen A, Gerlach J (1981) Vasopressin in anergic schizophrenia: A cross-over study with lysine-8-vasopressin and placebo. Psychopharmacology 74:379–382

    Google Scholar 

  • Rigter H, Crabbe JC (1979) Modulation of memory by pituitary hormones and related peptides. Vitamins and Hormones 3:153–241

    Google Scholar 

  • Spitzer RL, Endicott J, Robins E (1978) Research diagnostic criteria: Rationale and reliability. Arch Gen Psychiatry 35:773–782

    Google Scholar 

  • Vranckx C, Minne Ph, Benghezal A, Moeglen JM, Audibert A (1979) Vasopressin and schizophrenia. In: Obiols C, Ballus C, Gonzales-Monclus E, Pujol J (eds) Biological psychiatry today, Elsevier, North-Holland, Biomedical Press, pp 573–578

  • Weinberger DR, Fuller Torrey E, Neophytides AN, Wyatt RJ (1979) Lateral cerebral ventricular enlargement in chronic schizophrenia. Arch Gen Psychiatry 36:735–739

    Google Scholar 

  • Weingartner H, Gold P, Ballenger JC, Smallberg SA, Summers R, Rubinow DR, Post RM, Goodwin FK (1981) Effect of vasopressin on human memory function. Science 211:601–603

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stein, D., Bannet, J., Averbuch, I. et al. Ineffectiveness of vasopressin in the treatment of memory impairment in chronic schizophrenia. Psychopharmacology 84, 566–568 (1984). https://doi.org/10.1007/BF00431468

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00431468

Key words

Navigation